Study on Dynamic Molecular Behaviors in Crystal

当diallene衍生物（A）的晶体加热至1h时，dimethylencecyclene衍生物（B）由循环反应产生。自从晶体上有一个S-反式结构，从S-反式配置到一个S-反式结构中的异构反应应该在循环化反应之前发生。这是非常有趣的，因为它在水晶的小空间里的大分子运动场。这也证实了热转换过程是立体电的，当一个原型分子包含在一个手性主机复合体中，而前分子则被安排在一个手性形式中，它的嵌入式晶体中，并引入了光学活性的光电产品。在水晶、水晶、水晶晶格的包容性化合物中的摄影反应最多的情况下，由于反应过程而被摧毁。关于环己酮、香豆素和三硫氰胺在包含复合晶体中的对比、光二聚氰胺中的对比、光处理，从单晶体到单晶体和负电地给予对光学活性二聚体的光处理。这些反应是由X射线分析研究的，其他有机固体状态反应也是开发的。例如， Dieckmann反应、偶氮素形成反应和Michael Addition反应都在固体状态中有效地进行。在这些反应中，偶氮素形成反应是通过AFM方法研究的，无溶剂反应也是通过选择性地进行澄清的。例如，在固体状态gave meso-和Erythro-Addition产品中对苯乙烯和糖进行治疗，对丁二烯和糖醇进行治疗，尊重。这些数据清楚地显示了晶体容易移动的分子，以及在固体状态下选择性和有效地发生的反应。

When crystals of diallene derivative (A) is heated for 1h, dimethylencecyclobutene derivative (B) is produced by a cyclization reaction. Since A has a s-trans structure on crystal, isomenzation reaction from the s-trans configuration to a s-cis one should be occurred before the cyclization reaction. It is very interesting that such the big molecular motion occurs in a small space of crystal. It was also confirmed that the thermal conversion proceeds stereoselectively.When a prochiral molecule is included in a chiral host compound, the former is arranged in a chiral form in its inclusion crystal and its inadiation gave optically active photoreaction product. In most cases of the photoreaction in crystal, crystalline lattice of the inclusion compound is destroyed as the reaction proceeds. On the contrary, photodimerzation of cyclohexenone, coumarin, and thiocoumarin in inclusion complex crystal with optically active host compound proceeded from single-crystal-to-single-crystal and enantioselectively to give corresponding optically active dimer. These reactions were studied by X-ray analysis.Some other organic solid state reactions were also developed. For example, Dieckmann reaction, azomethine formation reaction, and Michael addition reaction were found to proceed efficiently in the solid state. Of these reactions, azomethine formation reaction was studied carefully by AFM method.Solvent-free reactions were also clarified to proceed selectively. For example, treatment of stilibene and chalcone with pyridine-HBr-BrィイD22ィエD2 salt in the solid state gave meso- and erythro- addition product, respectively. These data clearly show that molecules in crystal move easily and that reaction occurs selectively and efficiently in the solid state.