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Molecular epidemiology of hepatitis viruses in Indonesia

印度尼西亚肝炎病毒的分子流行病学

基本信息

批准号：
10041196
负责人：
HOTTA Hak
金额：
$ 2.24万
依托单位：
Kobe University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1998
资助国家：
日本
起止时间：
1998 至无数据
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10041196/
关键词：
hepatitis B virus hepatitis C virus hepatitis D virus GB virus TTvirus Indonesia seroepidemiology molecular epidemiology B型肝炎ウィルス C型肝炎ウィルス D型肝炎ウィルス GBウィルス TTウィルス

项目摘要

Molecular epiciemiological analysis of various hepatitis viruses in Surabaya, Indonesia, was performed.1. Hepatitis B virus (HBV) : Phylogenetic analysis of HBV DNA sequences amplified by PCR from sera of BBs Ag-positive asymptomatic carriers and patients with liver disease revealed that all the HBV strains tested belong to genotype B.2. Hepatitis D virus (HDV) : The prevalence of anti-HDV antibodies among HBs Ag-positive individuals was <0.5% (0/200). No information was available on the genotype of HDV.3. Hepatitis C virus (HCV) : HCV RNA titers in the serum were itis C viruscompared among different HCV subtypes. HCV-ld, the unique Indonesian subtype, was shown to be associated with high titers of viremia as was HCV-lb, the subtype most commonly found in Japan and thought to be associated with severe liver damage. On the other hand, HCV-2a was, in general, shown to be associated with relatively low titers of viremia compared with HCV-lb and HCV-ld. However, some HCV-2a strains isolated from patients with liver cirrhosis were found to be associated with high titers of viremia.4. GB virus C (GBV-C) : The prevalence of GBV-C, a new hepatitis virus candidate, among anti-HCV-positive and anti-HCV-negative blood donors was 21.9% (16/73) and 2.7% (4/150), respectively. Also, the prevalence among patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma and those on hemodialysis was 5.7% (3/57), 16.5% (13/79), 8.5% (6/71) and 21.7% (15/69), respectively. Phylogenetic analysis of GBV-C RNA sequences identified the presence of a novel subtype of GBV-C in Indonesia.5. TT virus (TTV) : The prevalence of TTV, another new hepatitis virus candidate, among patients with chronic hepatitis and liver cirrhosis and those on hemodialysis was 21.9% (14/64), 24.0%(18/75) and 32.8% (20/61), respectively.

对印度尼西亚泗水地区的各种肝炎病毒进行了分子流行病学分析。乙肝病毒：用聚合酶链式反应从BBS、Ag阳性无症状携带者和肝病患者的血清中扩增出HBVDNA序列的系统发育分析表明，所有检测的HBV株都属于B型。丁型肝炎病毒(HDV)：抗-HDV抗体在HBs Ag阳性个体中的流行率为0.5%(0/200)。目前尚无关于HDV的基因分型的信息。丙型肝炎病毒：丙型肝炎病毒不同亚型间血清中丙型肝炎病毒RNA滴度的比较。与在日本最常见的被认为与严重肝脏损害有关的丙型肝炎病毒1b亚型一样，印尼特有的丙型肝炎病毒1d亚型被证明与高滴度的病毒血症有关。另一方面，一般来说，与丙型肝炎病毒1b和丙型肝炎病毒1d相比，丙型肝炎病毒2a与相对较低的病毒血症滴度有关。然而，从肝硬变患者中分离出的一些丙型肝炎病毒2a株被发现与高滴度的病毒有关。GB病毒C(GBV-C)：新的候选肝炎病毒GBV-C在抗-丙型肝炎病毒阳性和阴性献血员中的感染率分别为21.9%(16/73)和2.7%(4/150)。慢性肝炎、肝硬变、肝细胞癌和血液透析患者的感染率分别为5.7%(3/57)、16.5%(13/79)、8.5%(6/71)和21.7%(15/69)。对GBV-C RNA序列的系统发育分析表明，印度尼西亚存在一种新的GBV-C亚型。TT病毒(TTV)：慢性肝炎、肝硬变和血液透析患者中TTV的感染率分别为21.9%(14/)、24.0%(18/75)和32.8%(20/61)。