Mycobacterial Cholesterol Degradation: A Unique Metabolic Weakness?

分枝杆菌胆固醇降解：一种独特的代谢弱点？

• 批准号: DP210103970
• 负责人: Prof James De Voss
• 金额: $ 35.02万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-03-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210103970
• 关键词: Mycobacterial; Cholesterol; Degradation; Unique; Metabolic

This project aims to understand the use of the steroid cholesterol as a source of essential metabolic building blocks by bacteria. Cholesterol utilisation is a key feature of many bacterial pathogens which have evolved to survive in niche environments. By understanding the initial step in cholesterol degradation and the bioinorganic and bioorganic chemistry of the metalloenzymes that catalyse it, this work aims to develop strategies to block this activity. This will turn a key strength of these bacteria into a potent weakness and will generate the proof of principle and knowledge required for the future development of effective strategies to combat pathogenic bacteria.

该项目旨在了解细菌使用类固醇胆固醇作为基本代谢构件的来源。胆固醇利用是许多细菌病原体的一个关键特征，它们已经进化到在利基环境中生存。通过了解胆固醇降解的初始步骤以及催化胆固醇降解的金属酶的生物无机和生物有机化学，这项工作旨在制定阻止这种活性的策略。这将把这些细菌的一个关键优势变成一个强大的弱点，并将为未来制定有效的战略来对抗病原菌产生所需的原理和知识的证明。