Bioproduction and bioavailability of steroidal saponins, bioactives in herbal medicines

草药中生物活性物质甾体皂苷的生物生产和生物利用度

• 批准号: LP140100958
• 负责人: Prof James De Voss
• 金额: $ 16.59万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-11-10 至 2017-11-09
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP140100958
• 关键词: Bioproduction; bioavailability; steroidal; saponins; bioactives

Steroidal saponins are a class of natural products that are common constituents of many herbal medicines and have been associated with many biological activities. Comprehensive studies into their biological activities are hampered by the small quantities available through isolation and the complexity of synthesis. The aim of this project is to identify, isolate and express the biosynthetic genes responsible for the critical steps in the synthesis of these compounds in the herbs themselves. This will allow for production of steroidal saponins using the isolated enzymes, facilitate biological studies and allow the production of critical standards required by the herbal industry for validation and regulation of herbal extracts.

甾体皂苷是一类天然产物，是许多草药的常见成分，具有多种生物活性。由于通过分离获得的数量很少，而且合成过程复杂，因此妨碍了对其生物活性的全面研究。该项目的目的是识别，分离和表达负责草药本身合成这些化合物的关键步骤的生物合成基因。这将允许使用分离的酶生产甾体皂苷，促进生物学研究，并允许生产草药工业所需的关键标准品，用于草药提取物的验证和监管。