Molecular mechanisms of pathogenicity of rinderpest virus
Molecular mechanisms of pathogenicity of rinderpest virus
批准号:
10044221
负责人:
YAMANOUCHI Kazuya
金额:
$8.64万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A).
财政年份:
1998
资助国家:
日本
项目状态:
已结题
起止时间:
1998 至 2000
中文摘要
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英文摘要
System to recover infectious rinderpest virus (RPV) from cDNA copy of the virus genome was established on the RBOK strain of RPV, and role of virus gene in the pathogenicity was examined. The RBOK that is widely used as an attnuated vaccine does not show virulence in rabbits, whereas the L strain, another attenuated RPV, shows high virulence in rabbits. Involvement of the H gene in such difference in the susceptibility of rabbits was examined by construction chimeric RBOK virus containing the H gene of the RPV-L strain. The results indicate that not only the H gene but also the other genes may be involved in the expression of virulence in rabbits.
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山内一也: "Rinderpest virus ISCOM vaccine induces protection against virulent RPV challenge"Vaccine. (In press). (2001)
Kazuya Yamauchi:“牛瘟病毒 ISCOM 疫苗可诱导抵抗有毒 RPV 攻击”疫苗(2001 年出版)。
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山内一也: "Cell-mediated immune responses incattle vaccinated with a recombinant vaccinia"J.gen.Virol. 80. 1627-1634 (1999)
Kazuya Yamauchi:“重组牛痘疫苗接种中的细胞介导的免疫反应”J.gen.Virol。 80. 1627-1634 (1999)
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山内一也: "Long-term protective immunity to rinderpest in cattle following a single vaccination with recombinant vaccinia virus"J. Gen. Virol.. 81. 1439-1446 (2000)
Kazuya Yamauchi:“重组痘苗病毒单次接种后牛对牛瘟的长期保护性免疫力”J. Gen. Virol.. 81. 1439-1446 (2000)
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Kobune, F3: "Recovery of pathogenic measles virus from cloned cDNA"J.Virol.. 74. 6643-6647 (2000)
Kobune, F3:“从克隆的 cDNA 中回收致病性麻疹病毒”J.Virol.. 74. 6643-6647 (2000)
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山内一也: "Identification of T-helper cell epitopes in the hypervariable region of the nucleocapsid protein of rinderpest virus"Vaccine. 18. 3077-3081 (2000)
Kazuya Yamauchi:“牛瘟病毒核衣壳蛋白高变区 T 辅助细胞表位的鉴定”疫苗。 18. 3077-3081 (2000)
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共 11 条
Molecular pathogenesis of transmissible spongiform encephalopathy
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财政年份:1997
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依托单位:
Molecular mechanisms of pathogenicity of rinderpestvirus and its molecular epidemio1ogy
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Studies on molecular basis of pathogenesis of rinderpest virus and molecular epidemiology
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Molecular genetics of subactute sclerosing panencephalitis (SSPE) virus
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Characterization of chicken complement and its application for complement fixation reaction
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橡胶炭疽菌致病相关突变体的鉴定及Pathogenicity-less1基因在致病上的功能分析
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项目类别:青年科学基金项目
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批准年份:2011
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负责人:郑肖兰
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依托单位: