RBAN - Roadside Breath Analysis of Narcotics

RBAN - 麻醉品路边呼吸分析

• 批准号: 10017013
• 金额: $ 38.19万
• 依托单位: EPINAL LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=10017013
• 关键词: RBAN; Roadside; Breath; Analysis; Narcotics

Drug-driving is a growing global problem, particularly in countries where enforcement is weak, or recreational use is legalised (30% of US, 32% of EU). In the UK there were 11,614 successful prosecutions for drug-driving in 2019, a 20% increase on the previous year. The most common narcotic is Tetrahydrocannabinol (THC), the psychoactive component of cannabis. Roadside use of the ubiquitous alcohol 'breathalyser' has played a significant part in changing attitudes and behaviours around drink driving.There is a need and a significant business opportunity to develop a product that can do the same for THC and a range of other narcotics for roadside, and industrial, insurance, prison and border force use. Current solutions rely on taking a significant sample of saliva from the suspect's mouth and carrying out spectroscopic analysis in a portable machine, or lateral flow analysis with colour changing strips. Collection of saliva is invasive, and testing typically takes between 5 and 20 minutes to complete, with results hard to interpret in the case of indicator strips. The University of Manchester (UoM) has developed a highly selective and sensitive sensor using 'odorant binding proteins' (OBPs) similar to those found in animal smell sensory channels. In these sensors a significant change in the electronic characteristics is detectable on the binding of very small amounts of the 'target' molecule. Deposition of a range of OBPs on parallel devices can produce a unique 'fingerprint' for discrimination in a noisy environment. Epinal Ltd is a recent startup and has been working with UoM in the past 18 months to demonstrate a route from the academic lab to a commercial device. This project aims to build on the current work and de-risk the route to market by demonstrating a narcotic breath detection system which can give results in a short (<2mins) time, with a realistic supply chain and manufacturing plan in the UK.

毒品驾驶是一个日益严重的全球问题，特别是在执法不力或娱乐活动合法化的国家(美国的30%，欧盟的32%)。在英国，2019年有11614起成功的毒驾起诉，比前一年增加了20%。最常见的麻醉剂是四氢大麻酚(THC)，它是大麻的精神活性成分。在路边使用无处不在的酒精“酒精测定仪”在改变人们对酒后驾驶的态度和行为方面发挥了重要作用。开发一种产品，可以对路边使用的THC和一系列其他毒品以及工业、保险、监狱和边境部队使用的THC和其他一系列毒品起到同样的作用，这是一个巨大的商业机会。目前的解决方案依赖于从嫌疑人的口腔中提取大量唾液样本，并在便携式机器中进行光谱分析，或者使用变色试纸进行横向流动分析。唾液的收集是侵入性的，检测通常需要5到20分钟才能完成，如果是指示条，结果很难解释。曼彻斯特大学(UOM)已经开发出一种高度选择性和灵敏的传感器，使用与动物气味感官通道中发现的类似的气味结合蛋白(OBP)。在这些传感器中，电子特性的显著变化可以在极少量的“靶”分子的结合上检测到。在并行设备上沉积一系列的OBP可以产生在嘈杂环境中进行辨别的独特“指纹”。Epinal Ltd是一家最近的初创公司，在过去的18个月里一直在与UOM合作，展示从学术实验室到商业设备的路线。该项目旨在当前工作的基础上，通过展示一种麻醉性呼吸检测系统来降低进入市场的风险，该系统可以在短时间(&lt；2分钟)内得出结果，并在英国具有现实的供应链和制造计划。