Investigating gamma/delta T cell receptor recognition determinants

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The immune system has evolved to protect hosts from pathogens. T cells are a critical component of the immune system that can recognise infected host cells. However, there remains many facets of T cell function that we do not understand. This project aims to investigate a major aspect of T cell immunity that is poorly understood, namely, gamma/delta T cell immunity. Specifically, using a multi-disciplinary approach, the anticipated outcome of the project is to unearth the molecular recognition determinants of gamma/delta T cells. The intended outcome is to provide basic fundamental insights and conceptual advances into a poorly understood, but crucial, component of the immune system.