Investigating gamma/delta T cell receptor recognition determinants

研究 γ/δ T 细胞受体识别决定因素

• 批准号: DP210103327
• 负责人: A/Prof JEROME LE NOURS
• 金额: $ 50.79万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210103327
• 关键词: Investigating; gamma; delta; cell; receptor

The immune system has evolved to protect hosts from pathogens. T cells are a critical component of the immune system that can recognise infected host cells. However, there remains many facets of T cell function that we do not understand. This project aims to investigate a major aspect of T cell immunity that is poorly understood, namely, gamma/delta T cell immunity. Specifically, using a multi-disciplinary approach, the anticipated outcome of the project is to unearth the molecular recognition determinants of gamma/delta T cells. The intended outcome is to provide basic fundamental insights and conceptual advances into a poorly understood, but crucial, component of the immune system.

免疫系统已经进化到保护宿主免受病原体的侵害。T细胞是免疫系统的重要组成部分，可以识别受感染的宿主细胞。然而，T细胞功能的许多方面我们还不了解。该项目旨在研究T细胞免疫中人们知之甚少的一个主要方面，即γ/δ T细胞免疫。具体而言，使用多学科的方法，该项目的预期成果是发掘γ/δ T细胞的分子识别决定因素。预期的结果是提供基本的基本见解和概念上的进步，了解不多，但至关重要的，免疫系统的组成部分。