Discovery of Novel Bacteriophage with the Capacity to Modulate Gut Bacteria

发现具有调节肠道细菌能力的新型噬菌体

• 批准号: DP210103296
• 负责人: A/Prof Jeremy Barr
• 金额: $ 38.79万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-03-25 至 2025-03-24
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210103296
• 关键词: Discovery; Novel; Bacteriophage; Capacity; Modulate

This project aims to experimentally validate the largest ever collection of bacterial viruses (bacteriophages) within the gut microbiome. This project expects to generate new knowledge in the area of bacteriophage biology and genomics by using the innovative approaches of wet-lab and bioinformatic genome analyses. Expect outcomes of this project include the discovery of novel phages using bioinformatics, wet-lab validation of their activity and characterisation of their potential to contribute new bacterial host metabolism. This should provide benefits, such as advancement to our understanding of bacteriophages, improved bioinformatic software, and a characterised collection of commercially valuable bacterial strains and phages.

该项目旨在通过实验验证肠道微生物组中有史以来最大的细菌病毒（噬菌体）集合。该项目希望通过使用湿实验室和生物信息学基因组分析的创新方法，在噬菌体生物学和基因组学领域产生新的知识。该项目的预期成果包括使用生物信息学发现新的微生物，对其活性进行湿实验室验证，并表征其促进新细菌宿主代谢的潜力。这应该会带来一些好处，比如提高我们对噬菌体的理解，改进生物信息学软件，以及收集有商业价值的细菌菌株和细菌。