Mucus control: Applying concepts from bacteriophage-mucus interactions

粘液控制：应用噬菌体-粘液相互作用的概念

• 批准号: DE170100525
• 负责人: A/Prof Jeremy Barr
• 金额: $ 26.03万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE170100525
• 关键词: Mucus; control; Applying; concepts; bacteriophage

This project aims to examine how mucus-adherent bacteriophage interact with bacteria in mucus as a mechanism to manipulate microbiomes. Bacterial infections at mucosal surfaces in animals are a serious global health threat. Traditionally antibiotics have been used to curb mucosal infections, but antibiotic resistance means new therapies are urgently needed. Bacteriophage – viruses that infect bacteria – can kill bacteria and might provide a layer of antimicrobial immunity in animal mucus. The anticipated outcomes are resolving how bacteriophage control bacteria within mucus, and applying concepts to bioengineer mucosal microbiomes.

本项目旨在研究黏液黏附噬菌体如何与黏液中的细菌相互作用，作为操纵微生物群的一种机制。动物粘膜表面的细菌感染是一个严重的全球健康威胁。传统上，抗生素一直被用来抑制粘膜感染，但抗生素耐药性意味着迫切需要新的治疗方法。噬菌体--感染细菌的病毒--可以杀死细菌，并可能在动物粘液中提供一层抗菌免疫力。预期的结果是解决噬菌体如何控制粘液中的细菌，并应用概念来生物工程粘膜微生物群。