Next generation enzymes using stimuli responsive protein/polymer hybrids

提高稳定性和对活性的控制是释放酶全部潜力的关键。先进的聚合物合成和合成生物学将结合在一起，设计出稳定的、生物响应的酶/聚合物杂化材料。这项研究将： 1：开发一种快速筛选方法，以确定聚合物与酶结合的最佳位置 2：评价酶/聚合物杂化材料的稳定性和生物响应性 3：将酶/聚合物杂化材料制成靶向纳米颗粒递送系统 该项目将检验聚合物-酶与细胞杂交的性能，然而这些创新在使用酶过程的其他领域也将有重要应用，如食品加工、生物燃料生产和农业。

Improved stability and control over activity are key to unlocking the full potential of enzymes. Advanced polymer synthesis and synthetic biology will be combined to engineer stable, bioresponsive enzyme/polymer hybrids. This study will: 1: Develop a rapid screening method to identify the optimal sites for polymer-to-enzyme attachment 2: Evaluate the stability and bioresponsive activity of enzyme/polymer hybrids 3: Formulate enzyme/polymer hybrids into a targeted nanoparticle delivery system This project will examine the performance of polymer-enzyme hybrids with cells, however these innovations will also have significant applications in other fields using enzymatic processes, such as food processing, biofuel production, and agriculture.