Next generation enzymes using stimuli responsive protein/polymer hybrids

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Improved stability and control over activity are key to unlocking the full potential of enzymes. Advanced polymer synthesis and synthetic biology will be combined to engineer stable, bioresponsive enzyme/polymer hybrids. This study will: 1: Develop a rapid screening method to identify the optimal sites for polymer-to-enzyme attachment 2: Evaluate the stability and bioresponsive activity of enzyme/polymer hybrids 3: Formulate enzyme/polymer hybrids into a targeted nanoparticle delivery system This project will examine the performance of polymer-enzyme hybrids with cells, however these innovations will also have significant applications in other fields using enzymatic processes, such as food processing, biofuel production, and agriculture.