Caveospheres: A versatile peptide delivery system
Caveospheres: A versatile peptide delivery system
批准号:
DP200100475
负责人:
A/Prof Angus Johnston
金额:
$35.53万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2020
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2020-01-01 至 2023-09-30
中文摘要
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英文摘要
Nanotechnology has the potential to transform the way we treat many diseases. This project will investigate a new type of nanoparticle, the caveosphere, and tests its effectiveness as a peptide delivery system. Caveospheres can protect delicate cargo from degradation, target cargo to specific cells that induce the maximum therapeutic response, and can be synthesised in large-scale, cost-effective batch fermentation. This study will:
1: Engineer biological function into caveospheres
2: Investigate the cellular behavior of the engineered caveospheres
3: Determine the therapeutic activity of caveospheres in vitro
It will develop a fundamental understanding of nanoparticles trafficking in cells, to make improved nanoparticle delivery systems.
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