Precise, Cytosolic Dendrimer Delivery Systems

该项目旨在使用精确靶向的树突分子技术来改善低渗透性分子向其亚细胞作用位点的传递。我们的尖端方法结合了创新的噬菌体筛选技术和先进的树突合成。该提案的结果将是：1)可大规模制造且成本合理的靶向系统，2)快速内化到特定靶细胞中的树状大分子传递系统，以及3)促进将其货物运送到细胞溶胶中的生物反应性树状大分子。这项工作将加强澳大利亚生物技术公司Starpharma和莫纳什大学之间非常成功的合作，设计下一代纳米材料输送系统。

This project aims to use precisely targeted dendrimer technology to improve the delivery of poorly permeable molecules to their subcellular sites of action. Our cutting edge approach combines innovative phage screening techniques and advanced dendrimer synthesis. The outcomes of this proposal will be: 1) a targeting system that is manufacturable at scale and reasonable cost, 2) a dendrimer delivery system that is rapidly internalised into specifc target cells and 3) bio-responsive dendrimers that promote delivery of their cargo into the cytosol. This work will strengthen a highly successful collaboration between the Australian biotech company Starpharma and Monash University, to design the next generation of nanomaterials delivery systems.