Precise, Cytosolic Dendrimer Delivery Systems

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This project aims to use precisely targeted dendrimer technology to improve the delivery of poorly permeable molecules to their subcellular sites of action. Our cutting edge approach combines innovative phage screening techniques and advanced dendrimer synthesis. The outcomes of this proposal will be: 1) a targeting system that is manufacturable at scale and reasonable cost, 2) a dendrimer delivery system that is rapidly internalised into specifc target cells and 3) bio-responsive dendrimers that promote delivery of their cargo into the cytosol. This work will strengthen a highly successful collaboration between the Australian biotech company Starpharma and Monash University, to design the next generation of nanomaterials delivery systems.