Miniaturised biosensors with high selectivity

具有高选择性的小型化生物传感器

• 批准号: DP210103160
• 负责人: Prof Fariba Dehghani
• 金额: $ 37.98万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-03-31 至 2025-03-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210103160
• 关键词: Miniaturised; biosensors; selectivity

This project aims to develop a technological platform for the fabrication of miniaturised and flexible sensors that enable the quantitative detection of important bioactive compounds such as fatty acids and biogenic amines. By utilising multi-enzymatic reactions in solid phase and engineering task-specific inks, chemiresistive sensors will be printed seamlessly as a whole. The sensors will respond to complex target biomolecules via a series of enzymatic reactions through which the analyte will convert to much simpler, reactive and hence measurable molecules. This project will enable to design miniaturised sensors for point-of-care detection of biomolecules that cannot be yet evaluated by the end users.

该项目旨在开发一个技术平台，用于制造柔性传感器，从而能够定量检测重要的生物活性化合物，如脂肪酸和生物胺。通过利用固相和工程任务特定墨水中的多酶反应，化学电阻传感器将作为一个整体无缝印刷。传感器将通过一系列酶反应对复杂的目标生物分子做出反应，通过这些酶反应，分析物将转化为更简单、反应性更强的可测量分子。该项目将能够设计用于最终用户无法评估的生物分子的即时检测的传感器。