Design a Targeted Delivery System for Probiotics

设计益生菌的靶向输送系统

• 批准号: LP190100143
• 负责人: Prof Fariba Dehghani
• 金额: $ 30.87万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-08-19 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP190100143
• 关键词: Design; Targeted; Delivery; System; Probiotics

The project aims to improve the effectiveness of probiotics by developing a targeted delivery system to the colon. This interdisciplinary research will generate new knowledge in the field of microbiota and develop new delivery systems for live microorganisms and other active compounds. Expected outcomes include increased understanding of the factors affecting the viability of probiotics during storage and passage through the gastro-intestinal tract, the establishment of probiotics into gut flora, and how this incorporation affects the dynamics of gut microbiota. The new technology can be utilised across a wide range of therapeutics that target the colon to promote the well-being of our society through commercialisation by industry partner.

该项目旨在通过开发针对结肠的靶向递送系统来提高益生菌的有效性。这项跨学科的研究将在微生物群领域产生新的知识，并为活微生物和其他活性化合物开发新的输送系统。预期成果包括增加对益生菌在储存和通过胃肠道期间影响其活力的因素的理解，益生菌进入肠道植物群的建立，以及这种结合如何影响肠道微生物群的动力学。这项新技术可以用于针对结肠的各种治疗方法，通过行业合作伙伴的商业化来促进我们社会的福祉。