A skin-on-a-chip device for investigating wound healing

用于研究伤口愈合的芯片皮肤设备

• 批准号: DP170102931
• 负责人: Prof Fariba Dehghani
• 金额: $ 26.66万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-04-07 至 2021-08-06
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170102931
• 关键词: skin; chip; device; investigating; wound

This project aims to research the mechanism of skin wound healing. It will design a skin-on-a-chip microfluidic device that mimics human skin in vitro. This device will reduce the need for animal studies and assess how active compounds heal wounds. This project will design smart polymers with superior properties for controlled delivery of multiple active compounds in this device and choose the most effective combination of compounds to boost skin healing rate. This knowledge may ultimately be used to develop wound dressings that maximise healing rate for various skin defects such as chronic wounds and decrease health care costs.

本课题旨在研究皮肤创面愈合的机制。该公司将设计一种芯片上皮肤微流控设备，在体外模拟人类皮肤。这种装置将减少对动物研究的需要，并评估活性化合物如何治愈伤口。该项目将设计性能优越的智能聚合物，在该设备中控制多种活性化合物的输送，并选择最有效的化合物组合来提高皮肤愈合率。这些知识最终可能被用来开发伤口敷料，以最大限度地提高各种皮肤缺陷的愈合率，如慢性伤口，并降低医疗保健成本。