TRANSPLANTATION/IMMUNE CELL DEPLETED/MARROW GRAFTS

移植/免疫细胞耗尽/骨髓移植

• 批准号: 3597243
• 负责人: BRUCE R BLAZAR
• 金额: $ 22.41万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-30 至 1993-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3597243
• 关键词: bone marrow transplantation; cytolysis; disease /disorder model; host neoplasm interaction; lymphokines; monoclonal antibody; neoplasm /cancer immunology

This contract will support investigation of the effect, in vivo, of recombinant lymphokines on bone marrow transplantation in a murine model. In addition, the efficacy of monoclonal antibodies in lysing host cells which may be involved in graft rejection will be examined. These studies are designed to test new methods for optimizing conditioning regimens to promote marrow engraftment.

该合同将支持在体内研究其影响， 重组淋巴因子在骨髓移植中的应用 小鼠模型。 此外，单克隆抗体的功效 在裂解可能参与移植排斥的宿主细胞中， 接受检查。 这些研究旨在测试新的方法， 优化预处理方案以促进骨髓移植。