TRANSPLANTATION/IMMUNE CELL DEPLETED/MARROW GRAFTS

移植/免疫细胞耗尽/骨髓移植

• 批准号: 3597247
• 负责人: BRUCE R BLAZAR
• 金额: $ 33.67万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-30 至 1993-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3597247
• 关键词: bone marrow transplantation; cytolysis; disease /disorder model; histocompatibility; host neoplasm interaction; lymphokines; monoclonal antibody; neoplasm /cancer immunology

This contract will support investigation of the effect, in vivo, of recombinant lymphokines on bone marrow transplantation in a murine model. In addition, the efficacy of monoclonal antibodies in lysing host cells which may be involved in graft rejection will be examined. These studies are designed to test new methods for optimizing conditioning regimens to promote marrow engraftment.

本合同将支持对体内效果的调查，

项目成果

GM-CSF-induced internal autocrine proliferation occurs in a compartment outside of the endoplasmic reticulum.

GM-CSF 诱导的内部自分泌增殖发生在内质网外部的隔室中。

• 发表时间: 1995
• 期刊: Experimental hematology
• 影响因子: 2.6
• 作者: Orchard,PJ;McIvor,RS;Singh,HA;Blazar,BR
• 通讯作者: Blazar,BR

Outcome of dialysis for acute renal failure in pediatric bone marrow transplant patients.

小儿骨髓移植患者急性肾衰竭透析的结果。

• 发表时间: 1994
• 期刊: Bone marrow transplantation
• 影响因子: 4.8
• 作者: Lane,PH;Mauer,SM;Blazar,BR;Ramsay,NK;Kashtan,CE
• 通讯作者: Kashtan,CE

Circulating macrophage colony-stimulating factor is not reduced in malignant osteopetrosis.

恶性骨石症中循环巨噬细胞集落刺激因子不减少。

• 发表时间: 1992
• 期刊: Experimental hematology
• 影响因子: 2.6
• 作者: Orchard,PJ;Dahl,N;Aukerman,SL;Blazar,BR;KeyJr,LL
• 通讯作者: KeyJr,LL

In utero engraftment of fully H-2-incompatible versus congenic adult bone marrow transferred into nonanemic or anemic murine fetal recipients.

将完全 H-2 不相容的与同源的成年骨髓在子宫内移植到非贫血或贫血的小鼠胎儿受体中。

• DOI: 10.1097/00007890-199309000-00039
• 发表时间: 1993
• 期刊: Transplantation
• 影响因子: 6.2
• 作者: Howson-Jan,K;Matloub,YH;Vallera,DA;Blazar,BR
• 通讯作者: Blazar,BR

Short-term ex vivo activation of splenocytes with anti-CD3 plus IL-2 and infusion post-BMT into mice results in in vivo expansion of effector cells with potent anti-lymphoma activity.

用抗 CD3 加 IL-2 短期离体激活脾细胞并在 BMT 后输注至小鼠体内，导致具有有效抗淋巴瘤活性的效应细胞体内扩增。

• 发表时间: 1994
• 期刊: Bone marrow transplantation
• 影响因子: 4.8
• 作者: Katsanis,E;Xu,Z;Anderson,PM;Dancisak,BB;Bausero,MA;Weisdorf,DJ;Blazar,BR;Ochoa,AC
• 通讯作者: Ochoa,AC