Defining the molecular switches that govern discrete cellular fates

定义控制离散细胞命运的分子开关

• 批准号: DP210103074
• 负责人: Dr Lan Nguyen
• 金额: $ 29.62万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-12-21 至 2024-12-20
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210103074
• 关键词: Defining; molecular; switches; govern; discrete

This project aims to elucidate how mammalian cells exploit the same molecular machinery to perform completely distinct jobs. While the repurposing of proteins by cells seems widespread, the mechanisms by which this occurs remains largely undefined. The project expects to generate new knowledge in the areas of cell signalling and systems biology, with important implications for many multi-functional proteins. It will utilise a highly innovative and interdisciplinary approach that tightly integrates mathematical modelling and biological experiments. The expected outcomes will aid strategies for reprogramming cells towards a desired phenotype, which will bring significant benefits to the fields of synthetic biology and bioengineering.

该项目旨在阐明哺乳动物细胞如何利用相同的分子机制来执行完全不同的工作。虽然细胞对蛋白质的再利用似乎很普遍，但其发生的机制在很大程度上仍不清楚。该项目预计将在细胞信号传导和系统生物学领域产生新的知识，对许多多功能蛋白质具有重要意义。它将采用高度创新和跨学科的方法，将数学建模和生物实验紧密结合在一起。预期的结果将有助于将细胞重编程为所需表型的策略，这将为合成生物学和生物工程领域带来重大利益。