Unravelling the role of heteroplasmy in mitochondrial adaptation

揭示异质性在线粒体适应中的作用

• 批准号: DP210102931
• 负责人: Prof Damian Dowling
• 金额: $ 33.05万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-04-01 至 2024-04-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210102931
• 关键词: Unravelling; role; heteroplasmy; mitochondrial; adaptation

This project aims to unravel the evolutionary implications of heteroplasmy – a scenario in which multiple mitochondrial DNA genotypes exist in one individual. Recent studies indicate heteroplasmy is widespread, and can be caused by paternal transmission of mtDNA. But the effects of heteroplasmy on evolutionary processes remain unknown. Leveraging state-of-the-art methods, this project expects to generate new knowledge in the areas of evolutionary ecology and mitochondrial genetics. Expected outcomes include discoveries that advance understanding of fundamental biological processes, and student training. Expected benefits include strengthening of Australia’s research capacity, by setting the research agenda in this rapidly developing field.

该项目旨在揭示异质性的进化含义-一个个体中存在多个线粒体DNA基因型的情况。最近的研究表明，异质性是普遍存在的，可能是由mtDNA的父系遗传引起的。但是异质性对进化过程的影响仍然未知。利用最先进的方法，该项目期望在进化生态学和线粒体遗传学领域产生新的知识。预期的结果包括发现，促进对基本生物过程的理解，并培养学生。预期的好处包括通过在这个快速发展的领域制定研究议程，加强澳大利亚的研究能力。