Mitochondria, maternal inheritance and the evolution of male life-histories

线粒体、母系遗传和男性生活史的进化

• 批准号: DP170100165
• 负责人: Prof Damian Dowling
• 金额: $ 26.34万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-06-30 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170100165
• 关键词: Mitochondria; maternal; inheritance; evolution; male

This project aims to unravel the extent to which maternal inheritance of the mitochondrial DNA renders it susceptible to accumulating mutations that are harmful only to males; an evolutionary theory called ‘Mother’s Curse’. Left unchecked, Mother’s Curse could threaten the long-term viability of populations. This project will combine experimental techniques in ecology, fruit fly genetics and a platform for measuring physiological phenotypes to test three hypotheses central to the theory. By testing these hypotheses, the project intends to understand the causes of sex differences in physiology, longevity and reproductive health, and improve awareness of evolutionary concepts that may ultimately affect human health.

该项目旨在揭示线粒体DNA的母系遗传在多大程度上使其容易受到仅对男性有害的突变的累积影响；一种称为“母亲的诅咒”的进化论。如果不加以控制，母亲的诅咒可能会威胁到人类的长期生存。该项目将结合生态学、果蝇遗传学的实验技术和测量生理表型的平台来测试该理论的三个假设。通过测试这些假设，该项目旨在了解生理、长寿和生殖健康方面性别差异的原因，并提高对可能最终影响人类健康的进化概念的认识。