Unlocking the secrets of the mitochondrion

解开线粒体的秘密

• 批准号: DP200100892
• 负责人: Prof Damian Dowling
• 金额: $ 30.69万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2025-01-01
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200100892
• 关键词: Unlocking; secrets; mitochondrion

This project aims to determine the frequency and mechanisms by which male-harming mutations (those with negative effects limited to males) accrue within the mitochondrial DNA. Theory predicts maternal inheritance of mitochondrial DNA will lead to accumulation of these mutations, but the real-world implications of this theory are unknown. Leveraging an innovative approach, this project expects to generate new knowledge into the causes of sex differences in physiology and health. Expected outcomes include insights that advance understanding of fundamental biological processes, and training of students. Expected benefits include strengthening of Australia’s research capacity, by setting the research agenda in this rapidly developing field.

该项目旨在确定线粒体DNA中伤害男性的突变（仅对男性产生负面影响的突变）的频率和机制。理论预测线粒体DNA的母系遗传将导致这些突变的积累，但这一理论的现实意义尚不清楚。利用创新的方法，该项目预计将产生新的知识到生理和健康的性别差异的原因。预期成果包括增进对基本生物过程的理解的见解和对学生的培训。预期的好处包括通过在这一迅速发展的领域制定研究议程，加强澳大利亚的研究能力。