Unlocking the secrets of the mitochondrion

该项目旨在确定线粒体DNA中男性伤害突变（那些对男性有负面影响的突变）的频率和机制。理论预测，线粒体DNA的母体遗传将导致这些突变的积累，但这一理论的现实意义尚不清楚。利用一种创新的方法，该项目期望产生关于生理和健康方面性别差异原因的新知识。预期的结果包括加深对基本生物过程的理解的见解，以及对学生的培训。预期的好处包括通过在这个快速发展的领域制定研究议程，加强澳大利亚的研究能力。

This project aims to determine the frequency and mechanisms by which male-harming mutations (those with negative effects limited to males) accrue within the mitochondrial DNA. Theory predicts maternal inheritance of mitochondrial DNA will lead to accumulation of these mutations, but the real-world implications of this theory are unknown. Leveraging an innovative approach, this project expects to generate new knowledge into the causes of sex differences in physiology and health. Expected outcomes include insights that advance understanding of fundamental biological processes, and training of students. Expected benefits include strengthening of Australia’s research capacity, by setting the research agenda in this rapidly developing field.