BRAZZX - Developing a scalable and predictable fermentation process for Brazzein, a new, non-caloric protein sweetener

BRAZZX - 为 Brazzein（一种新型无热量蛋白质甜味剂）开发可扩展且可预测的发酵工艺

• 批准号: 10022895
• 金额: $ 32.84万
• 依托单位: MAGELLAN LIFE SCIENCES LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=10022895
• 关键词: BRAZZX; Developing; scalable; predictable; fermentation

Calorie gluttony due to sugar over-consumption has led to a worldwide epidemic of obesity and diabetes. The recent statistics highlighting the high propensity of obese and diabetic individuals to require hospitalization and intensive care during COVID infection is a wakeup call for the world to tackle the sugar reduction agenda with renewed urgency.Current non-caloric sweeteners have not met the aims of previous sugar reduction efforts. This is primarily due to the unfavourable sweet taste profile of most of these sweeteners. Moreover, prolonged consumption of some artificial sweeteners has been shown to result in negative health consequences. Consumers demand a non-caloric sweetener that actually tastes like sugar and can be produced on a commercial scale. **Magellan is developing Brazzein as the next generation of non-caloric, natural sweeteners to overcome the limitations of currently available alternatives.**Brazzein is a natural protein molecule that is found in a rare West African fruit and has been consumed by humans and primates for centuries. The sweet taste quality of Brazzein is remarkably similar to tabletop sugar. Moreover, being 1500x sweeter than sugar, one would need to use very little of this sweetener in beverages and food, resulting in negligible calories being consumed.Magellan is developing a scalable and cost effective manufacturing platform for this remarkable natural molecule in order to advance the war against sugar.

由于糖的过度消费而导致的卡路里暴食导致了肥胖和糖尿病的全球流行。最近的统计数据显示，肥胖和糖尿病患者在COVID感染期间需要住院治疗和重症监护的倾向很高，这为世界敲响了警钟，要求世界以新的紧迫感来应对减糖议程。目前的无热量甜味剂尚未达到先前减糖努力的目标。这主要是由于这些甜味剂中的大多数的不利甜味特征。此外，长期食用一些人造甜味剂已被证明会导致负面的健康后果。消费者需要一种无热量的甜味剂，实际上尝起来像糖，可以在商业规模上生产。** 麦哲伦正在开发Brazzein作为下一代无热量的天然甜味剂，以克服目前可用替代品的局限性。Brazzein是一种天然蛋白质分子，存在于一种罕见的西非水果中，几个世纪以来一直被人类和灵长类动物食用。Brazzein的甜味质量与桌面糖非常相似。此外，由于比糖甜1500倍，人们只需要在饮料和食品中使用很少的这种甜味剂，导致消耗的卡路里可以忽略不计。麦哲伦正在为这种非凡的天然分子开发一个可扩展的和具有成本效益的制造平台，以推进对糖的战争。