AffeX Patient Management System - AffeX-PMS

AffeX 患者管理系统 - AffeX-PMS

• 批准号: 10027260
• 金额: $ 45.84万
• 依托单位: AFFERENT MEDICAL SOLUTIONS LTD
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=10027260
• 关键词: AffeX; Patient; Management; System; PMS

Raised blood pressure (BP) or hypertension is the single most preventable cause of stroke, heart attack, heart failure and cardiovascular death. It is also a leading factor for an increased risk of dementia, and kidney failure. By lowering BP the combined risk of associated disability and death can be reduced by more than a half. However, despite the widespread availability of drugs that help lower BP, ~40% patients using these drugs fail to properly control their BP (2.5m in England). Importantly, for these patients, there are no other regulatory approved treatment options available. Studies have shown that electrically stimulating nerves (autonomic nerve) can reduce BP in these patients. Several companies are working on solutions, all involve invasive devices and/or in-hospital procedures that are costly. In contrast, Afferent has developed a solution which achieves the same effect non-invasively. By attaching electrodes to the skin of the outer ear using an approach called transcutaneous autonomic neuromodulation, BP can be effectively reduced. This is currently being tested in a clinical trial by Queen Mary University London (QMUL).Afferent's solution is low cost, very safe and patients can treat themselves at home. This project will investigate how we could make this technology easier to use at home and also manage patients rather than them visit their GPs to have their condition managed remotely. As we are using an electronic device we can easily check when the device was used and if it was used correctly. If we also get patients to check their BP using a home BP-monitor we can then use internet technologies to send this information to the GP who can see if the patient is managing control and advise if any change to treatment is needed. This project will build the computer system that will enable this and also a mobile app so patients can self-monitor their own condition.We believe this technology could help other patients. 90% of stroke victims are cannot be given medical treatments to remove the blood clot in the brain and for these patients there is no other medical treatment. We think Afferent's technology may also help these patients recover by helping restore the blood supply to the parts of the brain which have been starved of oxygen. Our colleagues at QMUL will undertake a proof of concept study to determine if giving this treatment on arrival at hospital helps stroke victim recovery.

血压升高（BP）或高血压是中风、心脏病、心力衰竭和心血管死亡的最可预防的单一原因。它也是痴呆和肾衰竭风险增加的主要因素。通过降低血压，相关残疾和死亡的综合风险可降低一半以上。然而，尽管帮助降低血压的药物广泛存在，但约 40% 使用这些药物的患者未能正确控制血压（英格兰有 250 万）。重要的是，对于这些患者来说，没有其他监管机构批准的治疗选择。研究表明，电刺激神经（自主神经）可以降低这些患者的血压。几家公司正在研究解决方案，所有解决方案都涉及昂贵的侵入性设备和/或医院内程序。相比之下，Afferent 开发了一种非侵入性实现相同效果的解决方案。通过使用一种称为经皮自主神经调节的方法将电极连接到外耳皮肤，可以有效降低血压。目前伦敦玛丽女王大学 (QMUL) 正在对此进行临床试验测试。Afferent 的解决方案成本低、非常安全，患者可以在家中进行自我治疗。该项目将研究如何使这项技术更容易在家里使用，并管理患者，而不是让他们去看全科医生来远程管理他们的病情。当我们使用电子设备时，我们可以轻松检查该设备的使用时间以及是否正确使用。如果我们还让患者使用家用血压监测仪检查血压，那么我们就可以使用互联网技术将此信息发送给全科医生，全科医生可以查看患者是否正在控制血压，并建议是否需要对治疗进行任何改变。该项目将构建支持此功能的计算机系统以及移动应用程序，以便患者可以自我监控自己的病情。我们相信这项技术可以帮助其他患者。 90% 的中风患者无法接受药物治疗来清除大脑中的血凝块，并且对于这些患者来说没有其他药物治疗。我们认为 Afferent 的技术也可以通过帮助恢复大脑缺氧部分的血液供应来帮助这些患者康复。我们 QMUL 的同事将进行概念验证研究，以确定在到达医院时给予这种治疗是否有助于中风患者康复。