Quadri-nuclear MRI to Study Brain Energy Metabolism
四核 MRI 研究脑能量代谢
基本信息
- 批准号:10152654
- 负责人:
- 金额:$ 25.43万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-05-01 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:Adenosine TriphosphateAerobicAlzheimer&aposs DiseaseAstrocytesBrainBrain DiseasesCell DeathCell NucleusCell SurvivalCellsCerebral IschemiaComputer softwareConsumptionCustomDataDeuteriumDiagnosisDiffusionDiseaseEnergy MetabolismEtiologyFingerprintFrequenciesFunctional Magnetic Resonance ImagingGenerationsGlucoseGlutamatesGlutamineGlycolysisGoalsHealthHomeostasisHumanImageImaging DeviceIonsIschemiaLabelLinkMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMalignant NeoplasmsMeasurementMeasuresMetabolicMetabolic PathwayMetabolismMethodsMinorMitochondriaModelingMonitorNa(+)-K(+)-Exchanging ATPaseNoiseNormal tissue morphologyNuclearOrganOxidative PhosphorylationOxygenPathologyPatientsPerfusionPhosphocreatinePhosphorusPhysiologic pulsePilot ProjectsPlayProblem SolvingProcessProductionPrognosisProtocols documentationProtonsRecurrenceRelaxationReproducibilityResearch PersonnelResolutionRunningScanningSchemeScientistSensitivity and SpecificitySignal TransductionSodiumSodium PhosphorusStimulusStructureSystemTherapeutic InterventionTimeTissuesTransient Ischemic AttackTraumatic Brain InjuryVariantWaterbrain metabolismcerebral atrophycomputerized data processingdata acquisitiondensityextracellularflexibilityglucose uptakeimaging modalityimaging systemin vivoinorganic phosphateinsightinterestneuroimagingneuronal metabolismnovelpreventradio frequencyspectroscopic imagingtooltumor
项目摘要
Project Summary
Abnormalities in brain energy metabolism are strongly linked to a variety of pathologies including Alzheimer's
disease, traumatic brain injury, cancer, and ischemia. Magnetic resonance spectroscopy (MRS) and imaging
(MRI) allow non-invasive observation of nuclei (proton 1H, phosphorus 31P, sodium 23Na, and deuterium 2H)
present in many metabolites and ions that play key roles in various stages of this metabolic process. Up to this
point, technical challenges have prevented more than two nuclei from being studied simultaneously, which can
conceal causality and temporal relationships between metabolic functions. In this project, we propose to engi-
neer a quadri-nuclear MRI (4X-MRI) hardware system, acquisition method, and processing pipeline to enable
proton, sodium, phosphorus, and deuterium simultaneous or interleaved measurements within the same scan
protocol. Given its signal strength advantage, ultra-high-field MRI (7 T) is a natural fit for multinuclear MRI. How-
ever, custom hardware and acquisition methods are nonetheless required to interact with spins that resonate
at different frequencies (at 7 Tesla, 297 MHz for 1H, 120 MHz for 31P, 79 MHz for 23Na, 46 MHz for 2H) and
efficiently accommodate a range of spin dynamics. We will implement a quadruple-tuned radiofrequency (RF)
coil and hardware platform to excite and detect signals from 1H, 31P, 23Na, and 2H. The new hardware will
be paired with custom pulse sequences that exploit the significant differences between spin relaxation times to
enable multinuclear acquisitions in a single examination. Together, the tools developed in this study will enable
dynamic metabolic neuroimaging and will provide sufficient proof-of-principle to support a wide range of in vivo
studies in health, disease, and challenge paradigms. Specific aims of this pilot project are: (1) Data acquisition:
1H/31P/23Na/2H MRI at 7 T. (1.a) To build a quadruple-tuned 32-channel RF coil. (1.b) To develop a flexible
4X-MRI protocol with interleaved multinuclear acquisitions. (2) Data processing: Modeling the quantitative infor-
mation from the 4X-MRI data. (2.a) To optimize methods of quantification from all multinuclear acquisitions, such
as relaxation times from 1H data, intracellular sodium concentration from 23Na data, metabolite concentration
(glucose, glutamate/glutamine, lactate) from labeled 2H-glucose uptake, metabolite concentration (ATP, phospho-
creatine) from 31P. (2.b) Precision and accuracy in phantoms. (3) Application in vivo: (3.a) To assess repeatability
and reproducibility of 4X-MRI in healthy subjects. (3.b) To assess sensitivity and specificity of 4X-MRI in patients
with steno-occlusive disease (SOD). We will scan patients with SOD with 4X-MRI to measure differences in brain
metabolism between ischemic and normal tissues. This new 4X-MRI tool could help researchers and clinicians
interested in measuring multiple parameters related to brain energy in vivo, for both diagnosis or prognosis of
diseases, but also during therapy.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Ryan Brown', 18)}}的其他基金
Multinuclear MRI to Monitor Breast Cancer Therapy
多核 MRI 监测乳腺癌治疗
- 批准号:
10581988 - 财政年份:2022
- 资助金额:
$ 25.43万 - 项目类别:
Quadri-nuclear MRI to Study Brain Energy Metabolism
四核 MRI 研究脑能量代谢
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9893661 - 财政年份:2020
- 资助金额:
$ 25.43万 - 项目类别:
Reversing Diabetic Peripheral Neuropathy Through Exercise
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Metabolic Sodium MRI to Assess Early Response of Breast Cancer to Neoadjuvant Chemotherapy
代谢钠 MRI 评估乳腺癌对新辅助化疗的早期反应
- 批准号:
9386614 - 财政年份:2017
- 资助金额:
$ 25.43万 - 项目类别:
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