Biostatistics and Bioinformatics Core

生物统计学和生物信息学核心

• 批准号: 10153622
• 负责人: KYOUNGMI KIM
• 金额: $ 13.64万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-15 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10153622
• 关键词: Address; Advanced Development; Alzheimer' s Disease; Bioinformatics; Biological; Biometry; Cellular Metabolic Process; Clinical Trials; Communication; Communities; Data; Data Analyses; Data Collection; Databases; Development; Ensure; Future; Genotype; Human; Impairment; Individual; Informatics; Integrative Therapy; Intervention; Investigation; Ketosis; Life; Longevity; Methodology; Methods; Outcome; Phenotype; Procedures; Process; Program Research Project Grants; Publications; Randomized; Research; Research Design; Research Personnel; Research Project Grants; Research Support; Resources; Sample Size; Site; Specific qualifier value; Statistical Data Interpretation; Techniques; Therapeutic; Time; analytical method; data sharing; design; healthspan; healthy aging; heterogenous data; high dimensionality; improved; innovation; ketogenic diet; open source; pre-clinical; programs; protocol development; web site

Project Summary – Biostatistics and Bioinformatics Core (Core B) As described in the application, this P01 Program Project proposal seeks to gain a functional and mechanistic understanding of the connections between a ketogenic diet and long-term impact on life and health span outcomes as well as Alzheimer's disease. The breadth and depth of the proposed Program Project, and its particular needs for state-of-the-art analytic approaches that address longitudinal, high-dimensional, and integrative treatment of data on both phenotype and genotype, require advanced statistical expertise with a high degree of specialization. The Biostatistics and Bioinformatics Core will provide comprehensive, tailored statistical support for research to the needs of the individual projects and cores at all stages of the research process throughout the life of the Program Project, including study design, protocol development, specified data analysis, and interpretation of the results to ensure scientific rigor to achieve robust and unbiased results. The Biostatistics and Bioinformatics Core will also facilitate interactions between all projects and cores by providing database support in efforts to unite investigators and promote the research progress. The Biostatistics and Bioinformatics Core will achieve our objectives through three specific aims: 1) provide tailored statistical support to investigators and projects; 2) develop new statistical methodology for cutting-edge projects; 3) provide and maintain database support for data sharing. In total, the Biostatistics and Bioinformatics Core is essential to provide ready access to statistical resources and expertise necessary for the analytic challenges in the research projects and cores. The Biostatistics and Bioinformatics Core, jointly with the Administrative Core, will maintain a website to promote communication among researchers across the Program Project and with the scientific community.

生物统计学和生物信息学核心（核心B） 如申请中所述，此P01计划项目提案旨在获得功能和机械性 了解生酮饮食与对生命和健康的长期影响之间的联系 结果以及阿尔茨海默病。拟议计划项目的广度和深度，及其 特别需要最先进的分析方法，解决纵向，高维， 综合处理表型和基因型数据，需要先进的统计专业知识， 高度专业化。生物统计学和生物信息学核心将提供全面的，定制的 在研究的所有阶段，为研究提供统计支持，以满足各个项目和核心的需求 整个项目生命周期的过程，包括研究设计、方案制定、 数据分析和结果解释，以确保科学严谨性，从而获得稳健和公正的结果。 生物统计学和生物信息学核心还将促进所有项目和核心之间的互动， 提供数据库支持，努力团结研究者，促进研究进展。的 生物统计学和生物信息学核心将通过三个具体目标实现我们的目标：1）提供量身定制的 为调查人员和项目提供统计支助; 2）为最新的 项目; 3）提供和维护数据库支持数据共享。总的来说，生物统计学和 生物信息学核心是提供随时获得统计资源和必要的专业知识， 研究项目和核心中的分析挑战。生物统计学和生物信息学核心，联合 与行政核心，将维持一个网站，以促进研究人员之间的沟通， 计划项目和科学界。