Biostatistics and Bioinformatics Core

项目摘要--生物统计和生物信息学核心(核心B) 如申请书中所述，该P01计划项目建议书寻求获得功能性和机械性 了解生酮饮食与对生命和健康的长期影响之间的联系 结果以及阿尔茨海默氏症。拟议计划项目的广度和深度，及其 特别需要最先进的分析方法来解决纵向、高维和 对表型和基因型数据的综合处理，需要具有高级统计专业知识 专业化程度高。生物统计和生物信息学核心将提供全面的、量身定制的 在研究的所有阶段对个别项目和核心的需求提供研究统计支持 计划项目整个生命周期的流程，包括研究设计、协议制定、指定 数据分析和结果解释，以确保科学严谨，以实现稳健和不偏不倚的结果。 生物统计和生物信息学核心还将通过以下方式促进所有项目和核心之间的互动 为联合调查人员和推动研究进展提供数据库支持。这个 生物统计和生物信息学核心将通过三个具体目标实现我们的目标：1)提供定制的 为调查人员和项目提供统计支持；2)为尖端技术开发新的统计方法 项目；3)为数据共享提供和维护数据库支持。总体而言，生物统计学和 生物信息学核心对于提供随时可用的统计资源和必要的专业知识至关重要 研究项目和核心中的分析挑战。生物统计学和生物信息学核心，联合 与行政核心一起，将维护一个网站，以促进研究人员之间的交流 方案项目，并与科学界合作。

Project Summary – Biostatistics and Bioinformatics Core (Core B) As described in the application, this P01 Program Project proposal seeks to gain a functional and mechanistic understanding of the connections between a ketogenic diet and long-term impact on life and health span outcomes as well as Alzheimer's disease. The breadth and depth of the proposed Program Project, and its particular needs for state-of-the-art analytic approaches that address longitudinal, high-dimensional, and integrative treatment of data on both phenotype and genotype, require advanced statistical expertise with a high degree of specialization. The Biostatistics and Bioinformatics Core will provide comprehensive, tailored statistical support for research to the needs of the individual projects and cores at all stages of the research process throughout the life of the Program Project, including study design, protocol development, specified data analysis, and interpretation of the results to ensure scientific rigor to achieve robust and unbiased results. The Biostatistics and Bioinformatics Core will also facilitate interactions between all projects and cores by providing database support in efforts to unite investigators and promote the research progress. The Biostatistics and Bioinformatics Core will achieve our objectives through three specific aims: 1) provide tailored statistical support to investigators and projects; 2) develop new statistical methodology for cutting-edge projects; 3) provide and maintain database support for data sharing. In total, the Biostatistics and Bioinformatics Core is essential to provide ready access to statistical resources and expertise necessary for the analytic challenges in the research projects and cores. The Biostatistics and Bioinformatics Core, jointly with the Administrative Core, will maintain a website to promote communication among researchers across the Program Project and with the scientific community.