Core E. Biostatistics, Bioinformatics, and Research Design Core

项目摘要-生物统计学、生物信息学和研究设计核心 本申请寻求资金，以继续智力和发展研究所 残疾人研究中心（IDDRC）在加州大学戴维斯分校。IDDRC于2013年启动 并且是网络中14个IDDRC中最新的一个。生物统计学、生物信息学和研究设计核心 （BBRDC）旨在满足IDDRC项目和研究过程各个阶段的核心需求 通过提供咨询生物统计学家与广泛的互补专业知识和核心 一位能够与生物统计学家和IDDRC研究者合作设计 研究并提供分析，以确保项目目标得到满足，IDD的转化科学 先进BBRDC将通过实现三个具体目标来实现这一目标。目标1：提供统计数据 支持MIND研究所IDDRC研究人员从一系列学科，以促进转化科学 的IDD。这种支持将包括设计、统计分析（特别是复杂数据）和解释 的结果。目标2是为IDDRC研究者提供数据库支持，包括临床试验和其他 设计、数据输入界面和基于查询的功能。目标3是提供教育和指导 从学生到高级教师的生物统计技能和IDD转化研究所需的工具的水平。 BBRD核心将协助IDDRC调查人员和项目生成高质量数据， 科学严谨性和出版重现性的期望，同时支持临床前和临床 推进IDD转化科学的发现。BBRDC的主任是Kangmi Kim博士。

PROJECT SUMMARY – BIOSTATISTICS, BIOINFORMATICS, AND RESEARCH DESIGN CORE The present application seeks funding to continue the MIND Institute Intellectual and Developmental Disabilities Research Center (IDDRC) at the University of California, Davis. The IDDRC was launched in 2013 and is the newest of the 14 IDDRCs in the network. The Biostatistics, Bioinformatics, and Research Design Core (BBRDC) is designed to meet the needs of the IDDRC projects and cores at all stages of the research process by providing access to consulting biostatisticians with a broad range of complementary expertise and a core manager who will be able to work collaboratively with the biostatisticians and IDDRC investigators to design studies and provide analytics that ensure that project goals are met and the translational science of IDD is advanced. The BBRDC will achieve this goal by addressing three specific aims. Aim 1 is to provide statistical support to MIND Institute IDDRC investigators from a range of disciplines to advance the translational science of IDD. This support will encompass design, statistical analysis (especially for complex data), and interpretation of results. Aim 2 is to provide database support for IDDRC investigators, including clinical trials and other designs, data entry interface, and query-based capabilities. Aim 3 is to provide education and mentoring at all levels from student to senior faculty in the biostatistical skills and tools necessary for IDD translational research. The BBRD Core will assist IDDRC investigators and projects in generating high-quality data meeting the expectations of scientific rigor and reproducibility for publication, while supporting preclinical and clinical discoveries to advance the translational science of IDD. The Director of the BBRDC is Kyoungmi Kim, PhD.