Core E. Biostatistics, Bioinformatics, and Research Design Core

核心 E. 生物统计学、生物信息学和研究设计核心

• 批准号: 10085153
• 负责人: KYOUNGMI KIM
• 金额: $ 21.92万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10085153
• 关键词: Address; Advanced Development; Affect; Animal Model; Attention deficit hyperactivity disorder; Behavior; Behavioral Sciences; Bioinformatics; Biology; Biometry; California; Cells; Chromosomes; Clinical; Clinical Research; Clinical Trials; Cognition; Consult; Data; Data Analyses; Databases; Development; Developmental Delay Disorders; DiGeorge Syndrome; Discipline; Discipline of obstetrics; Doctor of Philosophy; Down Syndrome; Education; Ensure; Epidemiology; Faculty; Fragile X Syndrome; Funding; Future; Genetic; Genotype; Goals; Immunology; In Vitro; Incidence; Institutes; Integrative Therapy; Intellectual and Developmental Disabilities Research Centers; Knowledge; Mentors; Molecular Biology; Morbidity - disease rate; Neurosciences; Outcome; Pediatric Neurology; Phenotype; Process; Psychiatry; Publications; Reproducibility; Research; Research Design; Research Personnel; Statistical Data Interpretation; Students; System; Training; Translational Research; Universities; Work; analytical method; autism spectrum disorder; base; body system; complex data; design; expectation; high dimensionality; improved; interest; meetings; population based; pre-clinical; senior faculty; skills; social skills; tool

PROJECT SUMMARY – BIOSTATISTICS, BIOINFORMATICS, AND RESEARCH DESIGN CORE The present application seeks funding to continue the MIND Institute Intellectual and Developmental Disabilities Research Center (IDDRC) at the University of California, Davis. The IDDRC was launched in 2013 and is the newest of the 14 IDDRCs in the network. The Biostatistics, Bioinformatics, and Research Design Core (BBRDC) is designed to meet the needs of the IDDRC projects and cores at all stages of the research process by providing access to consulting biostatisticians with a broad range of complementary expertise and a core manager who will be able to work collaboratively with the biostatisticians and IDDRC investigators to design studies and provide analytics that ensure that project goals are met and the translational science of IDD is advanced. The BBRDC will achieve this goal by addressing three specific aims. Aim 1 is to provide statistical support to MIND Institute IDDRC investigators from a range of disciplines to advance the translational science of IDD. This support will encompass design, statistical analysis (especially for complex data), and interpretation of results. Aim 2 is to provide database support for IDDRC investigators, including clinical trials and other designs, data entry interface, and query-based capabilities. Aim 3 is to provide education and mentoring at all levels from student to senior faculty in the biostatistical skills and tools necessary for IDD translational research. The BBRD Core will assist IDDRC investigators and projects in generating high-quality data meeting the expectations of scientific rigor and reproducibility for publication, while supporting preclinical and clinical discoveries to advance the translational science of IDD. The Director of the BBRDC is Kyoungmi Kim, PhD.

项目摘要--生物统计学、生物信息学和研究设计核心 本申请寻求资金，以继续智力与发展研究所 加州大学戴维斯分校残疾研究中心(IDDRC)。IDDRC成立于2013年 是该网络14个国际数据中心中最新的一个。生物统计学、生物信息学和研究设计的核心 (BBRDC)旨在满足国际发展研究中心项目和核心在研究进程的所有阶段的需要 通过提供咨询生物统计学家的途径，提供广泛的补充专业知识和核心 能够与生物统计学家和IDDRC调查人员合作设计 研究并提供分析，以确保实现项目目标，并且IDD的翻译科学是 高级。BBRDC将通过实现三个具体目标来实现这一目标。目标1是提供统计数据 对思维研究所IDDRC研究人员的支持，以推动翻译科学的发展 缺铁性贫血患者。这种支持将包括设计、统计分析(特别是复杂数据)和解释 关于结果的。目标2是为IDDRC研究人员提供数据库支持，包括临床试验和其他 设计、数据输入界面和基于查询的功能。目标3是提供教育和指导 从学生到高级教员在生物统计学技能和工具方面的水平，这些技能和工具是IDD翻译研究所必需的。 BBRD核心将协助IDDRC调查人员和项目生成满足以下要求的高质量数据 对出版的科学严谨性和重复性的期望，同时支持临床前和临床 促进IDD翻译科学的发现。BBRDC的主任是金英美博士。