2021 Physical Science of Cancer Gordon Research Conference and Gordon Research Seminar

2021癌症物理科学戈登研究大会暨戈登研究研讨会

• 批准号: 10154448
• 负责人: Sharon Gerecht
• 金额: --
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2021-10-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10154448
• 关键词: 3-Dimensional; Address; Big Data; Biology; Biomedical Engineering; Cancer Biology; Cancer Science; Cancerous; Cells; Chemistry; Collaborations; Communication; Communities; Computational Science; Data; Development; Diagnostic; Discipline; Engineering; Environment; Exposure to; Face; Florida; Fostering; Funding Agency; Future; Genetic; Goals; Hour; Individual; Interdisciplinary Study; International; Journals; Malignant Neoplasms; Mathematics; Mechanical Stress; Medicine; Mentorship; Methodist Church; Methodology; Methods; Molecular; Motion; Neoplasm Metastasis; Oncology; Oral; Participant; Patients; Physics; Postdoctoral Fellow; Process; Research; Research Institute; Research Personnel; Role; Science; Scientist; Shapes; Site; Systemic disease; Texas; Therapeutic; Time; Tissues; Training; Universities; Woman; anticancer research; base; bench to bedside; cancer therapy; career; cell motility; clinical translation; design; diversity and inclusion; epithelial to mesenchymal transition; expectation; graduate student; innovation; interdisciplinary approach; mathematical model; mechanical properties; meetings; next generation; novel; personalized diagnostics; physical property; physical science; posters; role model; social; success; symposium; synergism; tumor; tumor progression; unpublished works

Project Summary/Abstract Despite the wide variety of genetic and molecular information available to characterize a patient's tumor, a precise individual prediction of cancer progression is only possible to a limited extend. This suggests that vital data about tumor progression are missing such as the physical and mechanical properties of cells and surrounding tissue. Considering the complexity of cancer as a systemic disease recently high expectations have been raised that an interdisciplinary approach by combining biology, chemistry, mathematics, engineering, big data, and physics with biomedicine will lead to convergent oncology. Emergent phenomena which are not directly triggered by a specific molecule can be only understood by a convergent approach. Partial support is requested for the 3rd Gordon Research Conference (GRC) on "Physical Science of Cancer" to be held from Feb.7-12, 2021, and the 2nd Gordon Research Seminar (GRS) to be held from Feb.6-7, 2021 at the GRC-selected conference hotel (The Hotel Galvez) in Galveston, Texas. The conference is promised to provide a forum for the presentation and discussion of recent advances and new ideas on multidisciplinary approaches and their success in understanding fundamental cancer progression as well as in developing potential translational perspectives. The long-term goal of this GRC is to facilitate the development and use of approaches to extend the range of cancer targets that can be tackled successfully. These will be achieved with the following aims: (1) Review advances and identify challenges in quantitative approaches in cancer. (2) Train the next generation of scientists to quantitatively investigate the underlying physical mechanisms that drive cancer (GRS) and facilitate diversity participation. (3) Foster new collaborations with emphasis on using quantitative approached to address challenges in cancer. Session topics have been selected on the basis of their potential impact on key scientific challenges of the field. Both conferences will catalyze researchers across diverse fields and stages in their academic career, encouraging new ideas and collaborations, and fostering mentorship of the next generation of crossdisciplinarity researchers. Poster sessions will provide ample opportunities for engagement between investigators at all levels. We anticipate that scientific interactions during this conference will impact cancer research in significant ways and result in establishing productive multi-disciplinary research collaborations. Collectively this conference will highlight the significant progress in the last two years, and catalyze the development of new concepts and synergies that will aim to shape the future of Physical Sciences in Cancer and the study of emergent phenomena which are not directly triggered by a specific molecule and can be only understood by a convergent approach. This effort will dissect and refine the way we ask and answer questions in the physics of cancer community, as well as educate on the thought process that drives translatable discoveries.

项目摘要/摘要 尽管有各种各样的遗传和分子信息可以用来表征患者的肿瘤，但 对癌症进展的准确个体预测只能在有限的范围内实现。这表明至关重要的是 关于肿瘤进展的数据缺失，如细胞的物理和机械特性以及 周围的组织。考虑到癌症作为一种系统性疾病的复杂性，最近人们对癌症的期望很高 提出了一种结合生物、化学、数学、工程学、大科学的跨学科方法 数据、物理学和生物医学将导致肿瘤学的融合。不是直接的紧急现象 由特定分子触发只能通过一种收敛的方法来理解。请求部分支持 第三届戈登研究会议(GRC)将于2月7日至12日举行，主题为“癌症的物理科学”。 2021年，以及将于2021年2月6日至7日在GRC选定的第二届戈登研究研讨会(GRS) 德克萨斯州加尔维斯顿的会议酒店(The Hotel Galvez)。这次会议承诺为 介绍和讨论多学科方法的最新进展和新思想及其 成功了解癌症的基本进展以及开发潜在的翻译 透视。这个GRC的长期目标是促进开发和使用方法来扩展 可以成功攻克的癌症靶点的范围。实现这些目标的目标如下： (1)回顾癌症定量方法的进展并确定挑战。 (2)培养下一代科学家，定量研究潜在的物理机制 推动癌症(GRS)，促进多样性参与。 (3)促进新的合作，强调使用量化方法来应对癌症方面的挑战。 会议议题是根据其对该领域关键科学挑战的潜在影响而选定的。 这两个会议将促进不同领域和不同阶段的研究人员的学术生涯， 鼓励新的想法和合作，并培养下一代跨学科的导师 研究人员。海报会议将为各级调查人员之间的接触提供充足的机会。 我们预计这次会议期间的科学互动将对癌症研究产生重大影响。 并导致建立富有成效的多学科研究合作。 总的来说，这次会议将突出过去两年取得的重大进展，并催化 旨在塑造癌症物理科学未来的新概念和协同效应的发展 以及对紧急现象的研究，这些现象不是由特定分子直接触发的，只能是 以一种趋同的方式理解。这项工作将剖析和改进我们提问和回答问题的方式 在癌症物理学社区，以及关于驱动可翻译的思维过程的教育 发现。