Micro Breath Biomarker Analyzer
Micro Breath Biomarker Analyzer
批准号:
10154757
负责人:
Chien Nguyen
金额:
$25.6万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-02-18 至 2023-01-31
关键词:
AcetoneAddressAdoptedAgricultural WorkersAirAlcoholsAldehydesAnestheticsAsthmaBiological MarkersBreath TestsCalibrationCarbon DioxideCardiovascular DiseasesChemicalsChronic Obstructive Airway DiseaseCitiesCollectionColumn ChromatographyCystic FibrosisDetectionDevelopmentDevicesDiabetes MellitusDiagnosisDietDimensionsDisease ManagementEnvironmental ExposureEnvironmental PollutionEvaluationExposure toFDA approvedGas ChromatographyGasesGenerationsHealth StatusHydrocarbonsIndividualKetonesLettersMalignant neoplasm of lungMass FragmentographyMass Spectrum AnalysisMeasurementMethodsMonitorNosePerformancePhaseReportingResearchResourcesSamplingSmall Business Innovation Research GrantSpeedSystemTechnologyTestingTuberculosisValidationVirginiaWorkZebrabasecoal-fired power plantcost effectivedetection testfire fighterimprovedmetal oxidephase 1 studyprototypesensorskillstooltwo-dimensionalventilator-associated pneumoniavolatile organic compound
中文摘要
项目摘要
这一阶段的SBIR将开发一种微型制造的呼吸生物标志物分析仪。有一个未满足的人
需要易于使用、经济高效的微型设备,以便进行快速、特定和灵敏的分析
呼吸生物标志物,特别是挥发性有机化合物(VOCs)。拟议的分析器是
建立在高性能MEMS(微电子机械系统)气相色谱(GC)基础上
柱子。初步研究表明,MEMS柱具有较高的分离效率和分离效率
速度,并开发了单MEMS一维微型GC的功能样机
纵队。在这一阶段的研究中,将采用MEMS柱技术来开发一种
微细加工的综合二维GC(Micro GCxGC),从而显著
提高微型GC分离能力,解决呼气VOC需求
生物标志物/剖面分析。第一阶段的具体目标是创建一个原型采样设备,用于
用两个MEMS柱萃取和预富集呼气VOCs的GCxGC
在台式GC上对呼气VOCs进行正交选择,并创建概念验证
所提出的基于MEMS柱的呼气VOC分析仪的原型。
拟议的产品旨在解决对呼气生物标志物的需求未得到满足的问题
学习。它有望在个人暴露评估和健康方面有广泛的应用
状态监控。
英文摘要
Project Summary
This Phase I SBIR will develop a microfabricated breath biomarker analyzer. There is an unmet
need for easy-to-use, cost-effective, miniature devices for rapid, specific, and sensitive analysis
of breath biomarkers, especially volatile organic compounds (VOCs). The proposed analyzer is
built on high-performance MEMS (microelectromechanical systems) gas chromatography (GC)
columns. A preliminary study demonstrated the MEMS column’s high separation efficiency and
speed, and developed a functional prototype of one-dimensional micro GC with a single MEMS
column. In this Phase I study, the MEMS column technology will be adopted to develop a
microfabricated comprehensive two-dimensional GC (micro GCxGC), so as to significantly
improve the separation power of micro GC and address the need for breath VOC
biomarker/profile analysis. Phase I specific aims are to create a prototype sampling device for
extraction and preconcentration of breath VOCs, demonstrate GCxGC with two MEMS columns
having orthogonal selectivity for breath VOCs on a benchtop GC, and create a proof-of-concept
prototype of the proposed MEMS column based breath VOC analyzer.
The proposed product aims to address the unmet need for point-of-need breath biomarker
studies. It is expected to have wide applications for personal exposure assessment and health
status monitoring.
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专著(0)
科研奖励(0)
会议论文
Autonomous Monitor for Toxic Gas Exposure
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批准号:10080038
-
项目类别:
-
资助金额:$22.5万
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财政年份:2020
-
负责人:Chien Nguyen
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依托单位:
海外基金