Micro Breath Biomarker Analyzer

项目摘要 第一阶段SBIR将开发一种微型呼吸生物标志物分析仪。存在未满足的 需要易于使用、具有成本效益的微型设备，以进行快速、特异和灵敏的分析 呼吸生物标志物，特别是挥发性有机化合物（VOC）。建议的分析仪是 基于高性能MEMS（微机电系统）气相色谱（GC） 列.初步研究证明了MEMS柱的高分离效率， 速度，并开发了一个功能样机的一维微GC与单一的MEMS 柱在第一期研究中，我们会采用微机电柱技术， 微制造的全面二维GC（微GCxGC），以显着 提高微量GC的分离能力，解决呼吸VOC的需求 生物标志物/概况分析。第一阶段的具体目标是建立一个原型取样装置， 呼吸VOC的提取和预浓缩，使用两个MEMS柱演示GCxGC 在台式GC上对呼吸VOC具有正交选择性，并创建概念验证 所提出的基于MEMS柱的呼吸VOC分析仪的原型。 拟议产品旨在解决对即时呼吸生物标志物的未满足需求 问题研究它有望在个人暴露评估和健康方面得到广泛应用 状态监测

Project Summary This Phase I SBIR will develop a microfabricated breath biomarker analyzer. There is an unmet need for easy-to-use, cost-effective, miniature devices for rapid, specific, and sensitive analysis of breath biomarkers, especially volatile organic compounds (VOCs). The proposed analyzer is built on high-performance MEMS (microelectromechanical systems) gas chromatography (GC) columns. A preliminary study demonstrated the MEMS column’s high separation efficiency and speed, and developed a functional prototype of one-dimensional micro GC with a single MEMS column. In this Phase I study, the MEMS column technology will be adopted to develop a microfabricated comprehensive two-dimensional GC (micro GCxGC), so as to significantly improve the separation power of micro GC and address the need for breath VOC biomarker/profile analysis. Phase I specific aims are to create a prototype sampling device for extraction and preconcentration of breath VOCs, demonstrate GCxGC with two MEMS columns having orthogonal selectivity for breath VOCs on a benchtop GC, and create a proof-of-concept prototype of the proposed MEMS column based breath VOC analyzer. The proposed product aims to address the unmet need for point-of-need breath biomarker studies. It is expected to have wide applications for personal exposure assessment and health status monitoring.