Micro Breath Biomarker Analyzer

微呼吸生物标志物分析仪

• 批准号: 10154757
• 负责人: Chien Nguyen
• 金额: $ 25.6万
• 依托单位: ZEBRA ANALYTIX, INC.
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-18 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10154757
• 关键词: Acetone; Address; Adopted; Agricultural Workers; Air; Alcohols; Aldehydes; Anesthetics; Asthma; Biological Markers; Breath Tests; Calibration; Carbon Dioxide; Cardiovascular Diseases; Chemicals; Chronic Obstructive Airway Disease; Cities; Collection; Column Chromatography; Cystic Fibrosis; Detection; Development; Devices; Diabetes Mellitus; Diagnosis; Diet; Dimensions; Disease Management; Environmental Exposure; Environmental Pollution; Evaluation; Exposure to; FDA approved; Gas Chromatography; Gases; Generations; Health Status; Hydrocarbons; Individual; Ketones; Letters; Malignant neoplasm of lung; Mass Fragmentography; Mass Spectrum Analysis; Measurement; Methods; Monitor; Nose; Performance; Phase; Reporting; Research; Resources; Sampling; Small Business Innovation Research Grant; Speed; System; Technology; Testing; Tuberculosis; Validation; Virginia; Work; Zebra; base; coal-fired power plant; cost effective; detection test; fire fighter; improved; metal oxide; phase 1 study; prototype; sensor; skills; tool; two-dimensional; ventilator-associated pneumonia; volatile organic compound

Project Summary This Phase I SBIR will develop a microfabricated breath biomarker analyzer. There is an unmet need for easy-to-use, cost-effective, miniature devices for rapid, specific, and sensitive analysis of breath biomarkers, especially volatile organic compounds (VOCs). The proposed analyzer is built on high-performance MEMS (microelectromechanical systems) gas chromatography (GC) columns. A preliminary study demonstrated the MEMS column’s high separation efficiency and speed, and developed a functional prototype of one-dimensional micro GC with a single MEMS column. In this Phase I study, the MEMS column technology will be adopted to develop a microfabricated comprehensive two-dimensional GC (micro GCxGC), so as to significantly improve the separation power of micro GC and address the need for breath VOC biomarker/profile analysis. Phase I specific aims are to create a prototype sampling device for extraction and preconcentration of breath VOCs, demonstrate GCxGC with two MEMS columns having orthogonal selectivity for breath VOCs on a benchtop GC, and create a proof-of-concept prototype of the proposed MEMS column based breath VOC analyzer. The proposed product aims to address the unmet need for point-of-need breath biomarker studies. It is expected to have wide applications for personal exposure assessment and health status monitoring.

项目摘要 这一阶段的SBIR将开发一种微型制造的呼吸生物标志物分析仪。有一个未满足的人 需要易于使用、经济高效的微型设备，以便进行快速、特定和灵敏的分析 呼吸生物标志物，特别是挥发性有机化合物(VOCs)。拟议的分析器是 建立在高性能MEMS(微电子机械系统)气相色谱(GC)基础上 柱子。初步研究表明，MEMS柱具有较高的分离效率和分离效率 速度，并开发了单MEMS一维微型GC的功能样机 纵队。在这一阶段的研究中，将采用MEMS柱技术来开发一种 微细加工的综合二维GC(Micro GCxGC)，从而显著 提高微型GC分离能力，解决呼气VOC需求 生物标志物/剖面分析。第一阶段的具体目标是创建一个原型采样设备，用于 用两个MEMS柱萃取和预富集呼气VOCs的GCxGC 在台式GC上对呼气VOCs进行正交选择，并创建概念验证 所提出的基于MEMS柱的呼气VOC分析仪的原型。 拟议的产品旨在解决对呼气生物标志物的需求未得到满足的问题 学习。它有望在个人暴露评估和健康方面有广泛的应用 状态监控。