Micro Breath Biomarker Analyzer

微呼吸生物标志物分析仪

• 批准号: 10154757
• 负责人: Chien Nguyen
• 金额: $ 25.6万
• 依托单位: ZEBRA ANALYTIX, INC.
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-18 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10154757
• 关键词: Acetone; Address; Adopted; Agricultural Workers; Air; Alcohols; Aldehydes; Anesthetics; Asthma; Biological Markers; Breath Tests; Calibration; Carbon Dioxide; Cardiovascular Diseases; Chemicals; Chronic Obstructive Airway Disease; Cities; Collection; Column Chromatography; Cystic Fibrosis; Detection; Development; Devices; Diabetes Mellitus; Diagnosis; Diet; Dimensions; Disease Management; Environmental Exposure; Environmental Pollution; Evaluation; Exposure to; FDA approved; Gas Chromatography; Gases; Generations; Health Status; Hydrocarbons; Individual; Ketones; Letters; Malignant neoplasm of lung; Mass Fragmentography; Mass Spectrum Analysis; Measurement; Methods; Monitor; Nose; Performance; Phase; Reporting; Research; Resources; Sampling; Small Business Innovation Research Grant; Speed; System; Technology; Testing; Tuberculosis; Validation; Virginia; Work; Zebra; base; coal-fired power plant; cost effective; detection test; fire fighter; improved; metal oxide; phase 1 study; prototype; sensor; skills; tool; two-dimensional; ventilator-associated pneumonia; volatile organic compound

Project Summary This Phase I SBIR will develop a microfabricated breath biomarker analyzer. There is an unmet need for easy-to-use, cost-effective, miniature devices for rapid, specific, and sensitive analysis of breath biomarkers, especially volatile organic compounds (VOCs). The proposed analyzer is built on high-performance MEMS (microelectromechanical systems) gas chromatography (GC) columns. A preliminary study demonstrated the MEMS column’s high separation efficiency and speed, and developed a functional prototype of one-dimensional micro GC with a single MEMS column. In this Phase I study, the MEMS column technology will be adopted to develop a microfabricated comprehensive two-dimensional GC (micro GCxGC), so as to significantly improve the separation power of micro GC and address the need for breath VOC biomarker/profile analysis. Phase I specific aims are to create a prototype sampling device for extraction and preconcentration of breath VOCs, demonstrate GCxGC with two MEMS columns having orthogonal selectivity for breath VOCs on a benchtop GC, and create a proof-of-concept prototype of the proposed MEMS column based breath VOC analyzer. The proposed product aims to address the unmet need for point-of-need breath biomarker studies. It is expected to have wide applications for personal exposure assessment and health status monitoring.

项目概要 第一阶段 SBIR 将开发一种微型呼吸生物标志物分析仪。有一个未满足的 需要易于使用、经济高效的微型设备来进行快速、特异性和灵敏的分析 呼吸生物标志物，特别是挥发性有机化合物（VOC）。建议的分析器是 基于高性能 MEMS（微机电系统）气相色谱 (GC) 列。初步研究表明 MEMS 色谱柱具有高分离效率和 速度，并开发了具有单个 MEMS 的一维微型 GC 的功能原型 柱子。在此一期研究中，将采用MEMS柱技术来开发 微制造综合二维气相色谱（micro GCxGC），从而显着 提高微型气相色谱仪的分离能力并满足呼吸 VOC 的需求 生物标志物/概况分析。第一阶段的具体目标是创建一个原型采样装置 呼吸 VOC 的提取和预浓缩，使用两个 MEMS 色谱柱演示 GCxGC 在台式 GC 上对呼吸 VOC 具有正交选择性，并创建概念验证 所提议的基于 MEMS 柱的呼吸 VOC 分析仪原型。 拟议产品旨在解决对需求点呼吸生物标记物未满足的需求 研究。预计它将在个人暴露评估和健康方面有广泛的应用 状态监控。