权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Monitoring the development of resistance to the novel insecticide clothianidin in Anopheles gambiae

监测冈比亚按蚊对新型杀虫剂噻虫胺的抗药性发展

基本信息

批准号：
10155410
负责人：
Colince Kamdem
金额：
$ 13.5万
依托单位：
CENTRE FOR RESEARCH IN INFECTIOUS DISEASES - CRID
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10155410
关键词：
Active Sites Address Africa Africa South of the Sahara African Agriculture Anopheles Genus Anopheles gambiae Area Cameroon Collaborations Communicable Diseases Country Culicidae Dangerousness Development Drug Metabolic Detoxication Effectiveness Environmental Risk Factor Enzymes Evaluation Formulation Fostering Generations Genes Genetic Genomics Geography Goals Incidence Insecticide Resistance Insecticides Institution International Intervention Knowledge Lead Malaria Measures Medicine Metabolic Monitor Mutation National Institute of Allergy and Infectious Disease Outcome Plasmodium Play Population Predisposition Public Health Research Research Proposals Residual state Resistance Resistance development Role Schools Speed Technology Transfer Testing Transgenic Organisms World Health Organization agricultural activity agricultural region burden of illness combat experimental study farmer fight against functional genomics genomic locus genomic tools intervention cost meetings new technology novel overexpression preservation prevent programs resistance gene vector vector control vector mosquito

项目摘要

Project Summary/Abstract Despite ongoing efforts to diversify malaria control interventions with new technologies such as the use of transgenic mosquitoes to suppress or replace wild vector populations, insecticides remain the cornerstone of strategies aimed at reducing the global burden of this disease. In sub-Saharan Africa in particular, the massive deployment of long-lasting insecticidal nets and indoor residual spraying has contributed to a significant reduction in malaria incidence in just two decades. For this reason, the development of insecticide resistance currently observed among vector populations is regarded as a very serious thread that can quickly undermine recent gains in malaria control. To preserve the effectiveness of insecticides used for malaria vector control, target interventions informed by sufficient knowledge of the susceptibility profile of local populations are more than crucial. Our project aims to study the development of resistance to clothianidin, a new insecticide recently approved for indoor residual spraying. To achieve our goal, we will capitalize on an international collaboration between Liverpool School of Topical Medicine in the UK, Centre for Research in Infectious Diseases in Cameroon as well as notional and international partners directly involved in the fight against malaria in Cameroon. This collaboration will foster capacity building and transfer of technologies in order to promote the use state- of-the-art genomic and functional genomic tools to address the underpinnings of insecticide resistance in malaria vectors in endemic countries. The specific aims of our project are: 1) to monitor the susceptibility of An. gambiae to clothianidin in Cameroon, 2) to evaluate the development and establishment of resistance in clothianidin-selected populations of An. gambiae, and 3) to determine the genetic loci underlying resistance to clothianidin. !

项目总结/文摘