A Multisectoral Strategy to Address Persistent Drivers of the HIV Epidemic in East Africa

解决东非艾滋病毒流行的持续驱动因素的多部门战略

基本信息

  • 批准号:
    10085144
  • 负责人:
  • 金额:
    $ 452.63万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-25 至 2025-06-30
  • 项目状态:
    未结题

项目摘要

Project Summary Progress towards HIV elimination will stall unless we overcome persistent drivers of new HIV infections by jointly optimizing HIV treatment and effectively delivering HIV prevention modalities. We aim to determine how to reduce HIV incidence to <0.1% using innovative strategies for HIV prevention and treatment to concurrently reach “persistent driver” populations with scalable interventions optimized and evaluated in two phases. • In Phase A (years 1-2), we will conduct individually randomized controlled trials (RCTs) to optimize the following prevention and treatment packages: 1) Dynamic Choice HIV Prevention with flexible Pre- exposure/post-exposure prophylaxis (PrEP/PEP) access integrated at family planning, antenatal care and HIV clinics and at community Youth Hubs that generate demand by also offering provision of life-skills, micro-finance and vocational training. 2) Dynamic Choice HIV Treatment with individual and system care options and services tailored for youth, men, mobile populations, and heavy drinkers. • In Phase B (years 3-5), we will test the hypothesis that a multi-sector intervention, offering dynamic choice of biomedical HIV prevention and treatment for persistent driver populations will increase viral suppression and prevention coverage and lead to a reduction in HIV incidence greater than standard of care. Aim 1: Optimize dynamic prevention and treatment interventions: We will conduct RCTs of PrEP/PEP dynamic prevention at multiple venues with high risk populations, and dynamic treatment interventions for multiple populations with unsuppressed viral load. Primary efficacy outcomes (HIV prevention coverage and viral suppression) will be used with implementation outcomes, costing, modelling projections, and stakeholder input to optimize dynamic prevention and treatment intervention packages for Phase B. Aim 2: a) Compare the effect of Dynamic Choice Prevention and Dynamic Choice Treatment interventions vs. standard-of-care on prevention coverage, viral suppression, HIV incidence and community health outcomes at 3 years. We will use a community randomized 2x2 factorial design to identify effect of each intervention package and their combination on prevention coverage, viral suppression, and other health outcomes. b) Elucidate pathways of intervention impact via evaluation of implementation and process outcomes and of socio-behavioral pathways of action at the community, clinic, and individual levels. Aim 3: Determine sustainability and inform policy. We will conduct multi-site costing of each aspect of the multi-component intervention and estimate costs per HIV infection averted and impacts on multi-disease disability-adjusted life-years (DALYs). Modelling incorporating study data will be used to inform stakeholders on anticipated long-term health impact and costs of alternative prevention and treatment strategies. Significance: This study will address major knowledge gaps on how to overcome key factors fueling the HIV epidemic that inform stakeholders and guide policies towards accelerating the path to HIV elimination.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Diane V Havlir其他文献

Dynamic choice HIV prevention with cabotegravir long-acting injectable in rural Uganda and Kenya: a randomised trial extension
乌干达和肯尼亚农村地区使用卡博特韦长效注射剂进行动态选择的艾滋病毒预防:一项随机试验扩展
  • DOI:
    10.1016/s2352-3018(24)00235-2
  • 发表时间:
    2024-11-01
  • 期刊:
  • 影响因子:
    13.000
  • 作者:
    Moses R Kamya;Laura B Balzer;James Ayieko;Jane Kabami;Elijah Kakande;Gabriel Chamie;Nicole Sutter;Helen Sunday;Janice Litunya;Joshua Schwab;John Schrom;Melanie Bacon;Catherine A Koss;Alex R Rinehart;Maya Petersen;Diane V Havlir;SEARCH Consortium
  • 通讯作者:
    SEARCH Consortium

Diane V Havlir的其他文献

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{{ truncateString('Diane V Havlir', 18)}}的其他基金

A Multisectoral Strategy to Address Persistent Drivers of the HIV Epidemic in East Africa
解决东非艾滋病毒流行的持续驱动因素的多部门战略
  • 批准号:
    10267216
  • 财政年份:
    2020
  • 资助金额:
    $ 452.63万
  • 项目类别:
A Multisectoral Strategy to Address Persistent Drivers of the HIV Epidemic in East Africa
解决东非艾滋病毒流行的持续驱动因素的多部门战略
  • 批准号:
    10438844
  • 财政年份:
    2020
  • 资助金额:
    $ 452.63万
  • 项目类别:
Strategic antiretroviral therapy and HIV testing for youth in rural Africa
为非洲农村青年提供战略性抗逆转录病毒治疗和艾滋病毒检测
  • 批准号:
    10216460
  • 财政年份:
    2018
  • 资助金额:
    $ 452.63万
  • 项目类别:
Strategic antiretroviral therapy and HIV testing for youth in rural Africa
为非洲农村青年提供战略性抗逆转录病毒治疗和艾滋病毒检测
  • 批准号:
    10252946
  • 财政年份:
    2018
  • 资助金额:
    $ 452.63万
  • 项目类别:
Strategic antiretroviral therapy and HIV testing for youth in rural Africa
为非洲农村青年提供战略性抗逆转录病毒治疗和艾滋病毒检测
  • 批准号:
    10469425
  • 财政年份:
    2018
  • 资助金额:
    $ 452.63万
  • 项目类别:
Simplified Isoniazid Preventive Therapy (SPIRIT) Strategy to Reduce TB Burden
减少结核病负担的简化异烟肼预防治疗 (SPIRIT) 策略
  • 批准号:
    10343685
  • 财政年份:
    2016
  • 资助金额:
    $ 452.63万
  • 项目类别:
Simplified Isoniazid Preventive Therapy (SPIRIT) Strategy to Reduce TB Burden
减少结核病负担的简化异烟肼预防治疗 (SPIRIT) 策略
  • 批准号:
    10064569
  • 财政年份:
    2016
  • 资助金额:
    $ 452.63万
  • 项目类别:
Reducing Failure-to-Initiate ART: Streamlined ART Start Strategy (START)
减少 ART 启动失败的情况:简化的 ART 启动策略 (START)
  • 批准号:
    8705385
  • 财政年份:
    2012
  • 资助金额:
    $ 452.63万
  • 项目类别:
Reducing Failure-to-Initiate ART: Streamlined ART Start Strategy (START)
减少 ART 启动失败的情况:简化的 ART 启动策略 (START)
  • 批准号:
    8295938
  • 财政年份:
    2012
  • 资助金额:
    $ 452.63万
  • 项目类别:
Reducing Failure-to-Initiate ART: Streamlined ART Start Strategy (START)
减少 ART 启动失败的情况:简化的 ART 启动策略 (START)
  • 批准号:
    8613427
  • 财政年份:
    2012
  • 资助金额:
    $ 452.63万
  • 项目类别:

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