Long term assessment of neurological effects after red tide exposure

赤潮暴露后神经系统影响的长期评估

• 批准号: 10155490
• 负责人: Laila Abdullah
• 金额: $ 19.01万
• 依托单位: ROSKAMP INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10155490
• 关键词: Accident and Emergency department; Acute; Address; Admission activity; Adverse effects; Aerosols; Affect; Biological; Biological Markers; Blood; Brain; Cell Count; Chronic; Chronic Fatigue Syndrome; Ciguatera Poisoning; Ciguatoxins; Clinical; Clinical Data; Collection; Communities; County; Cyclophosphamide; Data; Diagnosis; Dinophyceae; Dolphins; Dose; Economics; Elderly; Emergency department visit; Enrollment; Environmental Exposure; Event; Exposure to; Florida; Frequencies; Functional disorder; Future; Government Agencies; Headache; Health; Health system; Home; Human; Human Development; Human Volunteers; Immune; Immune response; Immunologic Markers; Inflammation; Ingestion; Inhalation; Investigation; Ion Channel Gating; L Cells; Life; Lipids; Long-Term Effects; Longitudinal Studies; Longitudinal cohort; Lung; Lung diseases; Mammals; Measurement; Measures; Mexico; Morbidity - disease rate; Neuraxis; Neurologic; Neurologic Effect; Neurologic Signs; Neurologic Symptoms; Neurological outcome; Neurotoxins; Outcome; Oxidative Stress; Peripheral; Personal Satisfaction; Pneumonia; Poisoning; Population; Psyche structure; Reaction; Recording of previous events; Recurrence; Reporting; Research Design; Risk; Sampling; Seawater; Shellfish; Symptoms; Temperature; Testing; Toxin; Trichechus; Vulnerable Populations; Water; Work; Workplace; aerosolized; biobank; brain health; brevetoxin; cohort; design; experience; falls; gulf coast; harmful algal blooms; human old age (65+); immune function; innovation; irritation; mortality; nervous system disorder; neurotoxic; patient subsets; recruit; red tide; respiratory; voltage; volunteer

Abstract: Karenia brevis (K. brevis), the microalgae responsible for Red Tide harmful algal blooms, regularly releases a suite of potent neurotoxic brevetoxins in southwest Florida and is intermittently responsible for massive marine life morbidity and mortality. While these blooms have been documented in the Gulf of Mexico since the 16th century, evidence suggests that their frequency and intensity have been increasing in recent decades, most likely driven by human development in Florida and higher Gulf water temperatures. Although the acute negative consequences of Red Tide exposure on pulmonary health in humans are relatively well-documented, recent studies of ER admissions during Red Tide blooms also demonstrate increased diagnoses of neurological conditions. The impact on the central nervous system of repeat exposure of brevetoxin in humans is not known, but frequent exposure to the closely-related ciguatoxin can result in chronic neurological illness including conditions similar to chronic fatigue syndrome. Furthermore, other chronically exposed mammals, like manatees and dolphins, display a wide variety of neurological signs most likely due to the known mechanism of action of brevetoxins on voltage-gated ion channels in the peripheral and central nervous systems. One of the longest Red Tide blooms on record, November 2017 to February 2019, exposed southwest Florida residents to prolonged and intense aerosolized brevetoxin levels. We have begun enrolling volunteer residents from the two-county region of Manatee and Sarasota (collectively “Manasota”) who were differentially exposed during this bloom by virtue of their home or work locations. These subjects have provided demographic, health history, and zone/activity information as well as biological samples. These subjects will be part of the cohort that we would like to follow over 18 months during periods of absence or presence of subsequent blooms. The cohort recruitment will be completed with volunteers who live in coastal regions as well as those who live further inland and who will have experienced much lower, or no, brevetoxin aerosol exposure. We will correlate their exposure to aerosolized brevetoxins with neurological diagnoses. Furthermore, we will examine biomarkers of brevetoxin exposure in relation to the same neurological sequelae. The purpose of this study is to determine how exposure relates to neurological diagnoses and to begin to characterize differences between those that develop neurological diagnoses and those that do not. For instance, exposure dose, duration, or markers of immune response may predict neurological outcomes. This work will be the first to provide longitudinal data on the neurological consequences of repeat brevetoxin exposure, generate a cohort for the examination of long-term outcomes and will establish a biorepository for studies of brevetoxin exposure and human health.

摘要： 造成赤潮有害藻类水华的微藻--短角卡氏杆菌(Karenia brevis(K.brevis))定期释放一种 在佛罗里达州西南部发现了一组强大的神经毒性短杆菌毒素，并间歇性地导致了大规模的海洋 生命发病率和死亡率。而这些水华自16日以来一直在墨西哥湾被记录下来 本世纪以来，有证据表明，近几十年来，它们的频率和强度一直在增加，大多数 这可能是由佛罗里达州的人类发展和墨西哥湾较高的水温推动的。虽然是急性的 赤潮暴露对人类肺部健康的负面影响是相对有据可查的， 最近对赤潮爆发期间ER入院的研究也表明， 神经方面的情况。短杆菌毒素重复暴露对人体中枢神经系统的影响 目前尚不清楚，但频繁接触与雪卡毒素密切相关的雪卡毒素可导致慢性神经疾病 包括类似慢性疲劳综合症的情况。此外，其他长期接触的哺乳动物，如 海牛和海豚表现出各种各样的神经体征，很可能是由于已知的机制 短杆菌毒素对外周和中枢神经系统电压门控离子通道的作用。其中之一 有记录以来最长的赤潮爆发，2017年11月至2019年2月，暴露在佛罗里达州西南部 居民对长时间和强烈的雾化短毒素水平。 我们已经开始招募来自马纳蒂和萨拉索塔两县地区的志愿居民(统称为 “马纳索塔”)，在这次水华期间，由于他们的家或工作地点，他们受到了不同的暴露。这些 受试者提供了人口统计、健康史、区域/活动信息以及生物学信息 样本。这些受试者将是我们希望在18个月内跟踪调查的队列的一部分 没有或有随后的花朵。队列招募将由居住在这里的志愿者完成 在沿海地区，以及那些生活在更内陆的人，他们的经历要低得多，或者没有， 短杆菌毒素气雾剂暴露。我们将把他们暴露在雾化短毒素中与神经学联系起来 诊断。此外，我们将研究与短杆菌毒素暴露相关的生物标志物。 神经后遗症。这项研究的目的是确定暴露与神经学的关系。 诊断并开始描述那些发展成神经学诊断的人和 那些不喜欢的人。例如，暴露剂量、持续时间或免疫反应的标志物可以预测 神经学结果。这项工作将是第一次提供关于神经学的纵向数据 反复接触短杆菌毒素的后果，产生一个长期结果检查的队列 并将建立一个生物储存库，用于研究短杆菌毒素暴露和人类健康。