Unravelling the complexities of cell death pathways

揭示细胞死亡途径的复杂性

• 批准号: DP210101806
• 负责人: Prof Sammy Bedoui
• 金额: $ 47.89万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-03-17 至 2024-03-16
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210101806
• 关键词: Unravelling; complexities; cell; death; pathways

This project aims to test if cells can flexibly rewire their cell death pathways to ensure that the absence or inhibition of one type of cell death can be compensated through the triggering of another. The project expects to generate new knowledge in the area of programed cell death, and more specifically will address why cells have multiple programmed ways to die. Expected outcomes of this project include the provision of unprecedented insights into the molecular regulation of how cells orchestrate and integrate cell death pathways. This should provide significant benefits, such as providing the knowledge base needed to improve our abilities to manipulate cell death both in basic research and commercial applications of cell death.

该项目旨在测试细胞是否可以灵活地重新连接其细胞死亡途径，以确保一种类型的细胞死亡的缺失或抑制可以通过触发另一种类型的细胞死亡来补偿。该项目希望在程序化细胞死亡领域产生新的知识，更具体地说，将解决为什么细胞有多种程序化死亡方式。该项目的预期成果包括对细胞如何协调和整合细胞死亡途径的分子调控提供前所未有的见解。这应该会带来显著的好处，例如提供所需的知识基础，以提高我们在细胞死亡的基础研究和商业应用中操纵细胞死亡的能力。