Basic and Translational Science in Heart Failure

心力衰竭的基础和转化科学

• 批准号: 10153856
• 负责人: Martin E Young
• 金额: $ 26.89万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10153856
• 关键词: Basic Science; Heart failure; Translational Research

ABSTRACT While cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in the US, the mortality burden of specific diseases has changed over the last few decades. Despite a decline in death rates for coronary artery disease since 1970, heart failure (HF) prevalence and mortality have increased. The expanded clinical burden, prognostic import, and health needs related to HF highlight the importance of complementary training of teams of basic, clinical, and population scientists. Hence, we propose the Basic and Translational Science in Heart Failure (BTSHF) Training Program, designed to specifically mentor clinical and research post-doctoral trainees in broad aspects of HF pathophysiology (disease mechanisms), diagnostics (biomarkers and imaging), therapeutics (pharmacological, biological, devices), epidemiology (population science, personalized medicine, and clinical outcomes), as well as relevant methodologies (disease models, stem cells, ‘omics’ approaches, and biostatistics). At the heart of the training program reside three thematic cores - Cellular and Molecular Mechanisms; New Diagnostics and Therapeutics; and Clinical Epidemiology and Outcomes. In close collaboration with the University of Alabama at Birmingham (UAB) Office of Postdoctoral Education and Center for Clinical and Translational Science, the 2 to 3 year BTSHF training program has been specifically tailored to foster the development of future translational researchers with scientific interests in HF. This includes establishment of a new interdisciplinary didactic course that exposes trainees to cutting edge scientific techniques (e.g., non-invasive imaging, translational study design, large data set analysis) and concepts (e.g., cardiometabolics, epigenetics, inflammation, tissue regeneration). The program also takes advantage of multiple seminar series and symposia organized by various UAB Departments and Centers, including the Comprehensive Cardiovascular Center. A diverse group of primary faculty from multiple Departments/Schools have been assembled, who possess established track records in HF related research and/or mentorship, as well as several secondary and junior faculty, whose collective expertise span the three scientific cores. Highly meritorious MD and PhD fellows will be recruited and matched with a mentoring team consisting of four complementary faculty mentors from the distinct scientific cores, including one junior faculty. Trainee progress and mentorship effectiveness will be evaluated at regular intervals, and facilitated throughout the training period by established mechanisms, including mentoring roundtables. The proposed program is enriched further by the highly collaborative and interdisciplinary environment afforded by our institution, which has a longstanding track record in both cardiovascular and translational research, as well as in mentorship of future independent researchers and scientific leaders. Establishment of the BTSHF program will ensure adequate training of future translational researchers armed with the appropriate skills to tackle the growing HF epidemic.

摘要 虽然心血管疾病（CVD）仍然是美国发病率和死亡率的主要原因， 过去几十年来，特定疾病的死亡率负担发生了变化。尽管死亡率有所下降 自1970年以来，冠状动脉疾病的心力衰竭（HF）患病率和死亡率增加。的 扩大的临床负担、预后意义和与HF相关的健康需求强调了以下方面的重要性： 对基础、临床和人口科学家团队进行补充培训。因此，我们建议基本 和心力衰竭转化科学（BTSHF）培训计划，旨在专门指导 HF病理生理学（疾病机制）广泛方面的临床和研究博士后学员， 诊断学（生物标志物和成像）、治疗学（药理学、生物学、器械）、流行病学 （人口科学，个性化医疗和临床结果），以及相关的方法 （疾病模型、干细胞、“组学”方法和生物统计学）。培训计划的核心是 三个主题核心-细胞和分子机制;新的诊断和治疗;和临床 流行病学和结果。与亚拉巴马大学伯明翰分校（UAB）办公室密切合作 博士后教育和临床与转化科学中心，2至3年BTSHF培训 该计划专门为促进未来翻译研究人员的发展而量身定制 对HF有科学兴趣这包括建立一个新的跨学科教学课程， 让受训者接触尖端的科学技术（例如，非侵入性成像，转化研究设计， 大数据集分析）和概念（例如，心脏代谢、表观遗传学、炎症、组织再生）。 该计划还利用多个研讨会系列和研讨会组织的各种UAB的优势 部门和中心，包括综合心血管中心。一个多样化的小学生群体 来自多个部门/学校的教师已经聚集，谁拥有既定的跟踪记录， HF相关的研究和/或指导，以及几个中学和初中教师，其集体 专业知识跨越三大科学核心。将招募非常优秀的MD和PhD研究员， 与由四名来自不同学院的互补教师导师组成的指导团队相匹配 科学核心，包括一名初级教师。将评估学员的进度和指导效果 在整个培训期间，由现有机制提供便利， 指导圆桌会议。拟议的方案进一步丰富了高度协作和 我们的机构提供的跨学科环境，在这两个方面都有长期的记录 心血管和转化研究，以及未来独立研究人员的导师， 科学领袖BTSHF计划的建立将确保未来的充分培训 翻译研究人员配备了适当的技能，以应对日益增长的HF流行病。

项目成果

Echocardiography for extracorporeal membrane oxygenation.

• DOI: 10.1111/echo.15266
• 发表时间: 2022-03
• 期刊: ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
• 影响因子: 1.5
• 作者: Hussey, Patrick T.;von Mering, Gregory;Nanda, Navin C.;Ahmed, Mustafa I.;Addis, Dylan R.
• 通讯作者: Addis, Dylan R.

Circadian rhythms in cardiac metabolic flexibility.

• DOI: 10.1080/07420528.2021.1939366
• 发表时间: 2023-01
• 期刊: Chronobiology international
• 影响因子: 2.8
• 作者: Young ME;Latimer MN
• 通讯作者: Latimer MN

Halogen gas exposure: toxic effects on the parturient.

• DOI: 10.1080/15376516.2020.1736702
• 发表时间: 2021-05
• 期刊: Toxicology mechanisms and methods
• 影响因子: 3.2
• 作者: Addis DR;Lambert JA;Ford DA;Jilling T;Matalon S
• 通讯作者: Matalon S

Perioperative Implications of the 2020 American Heart Association/American College of Cardiology Guidelines for the Diagnosis and Treatment of Patients with Hypertrophic Cardiomyopathy: A Focused Review.

2020 年美国心脏协会/美国心脏病学会肥厚型心肌病诊断和治疗指南的围手术期影响：重点回顾。

• DOI: 10.1053/j.jvca.2021.07.024
• 发表时间: 2022
• 期刊: Journal of cardiothoracic and vascular anesthesia
• 影响因子: 2.8
• 作者: Addis,DylanR;Townsley,MatthewM
• 通讯作者: Townsley,MatthewM

Hemodynamic Stimulation Using the Biomimetic Cardiac Tissue Model (BCTM) Enhances Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

• DOI: 10.1159/000496934
• 发表时间: 2018
• 期刊: Cells, tissues, organs
• 作者: Rogers AJ;Kannappan R;Abukhalifeh H;Ghazal M;Miller JM;El-Baz A;Fast VG;Sethu P
• 通讯作者: Sethu P