Viral Pathogenesis Core

项目摘要 第三海岸CFAR核心E：病毒致病核心（VPC） 病毒发病机制核心（VPC）带来了高度复杂的工具，服务和试剂的生物艾滋病毒 TC CFAR的跨学科研究团队。VPC用户数最多的地址 总体目标3：发现/发展科学创新，更好地预防艾滋病毒和改善对所有人的治疗 艾滋病毒感染者的生活条件。我们提供并正在加强咨询和培训， 促进我们跨越艾滋病毒研究学科的广度在大学的不同团队的能力 芝加哥和西北大学将为开发新的生物干预措施做出贡献， 减少艾滋病毒的传播，解决艾滋病毒阳性人群中老年慢性病风险增加的问题， 推动艾滋病治疗研究。VPC已经有了在工作中添加生物工具的机会 艾滋病毒临床和行为研究人员，解决总体目标1（改善艾滋病毒预防和护理 连续体）和2（非艾滋病合并症）。新活动将增加实验室研究人员的参与 研究衰老生物学和衰老相关疾病的人有兴趣在艾滋病毒衰老方面的合作， 支持总体目标2。VP核心的具体目标是：1）提供病毒学的扩展菜单， 成像和免疫测定，以及咨询和导航到其他学科和技术， 这将推动创新的、跨学科的艾滋病毒研究; 2）提供艾滋病毒的专家设计/性能 实验，以及成像、系统生物学、组学方面的咨询/导航; 3）加强信息 与其他艾滋病毒研究学科和实验室/翻译研究人员的交流和伙伴关系 对非艾滋病合并症感兴趣的新艾滋病毒感染者。VPC研究艾滋病毒的尖端工具 分子、细胞、组织和有机体水平包括高度复杂的仪器;经验丰富的技术人员， 支持和定制培训;以及专家咨询/新技术导航，创意 实验设计和创新的致病假说。VPC的主要目标是使这些 分子病毒学家、临床/转化研究人员和 行为/社会科学家VPC在所有实验中增加了价值和必要的严格性，包括项目 以前有限或无法获得多重生物标志物测定和病毒学等方法， 评估。Data Insight Group（DIG）正在将咨询和导航扩展到专业的多组学 研究这种病毒的方法，以及。DIG汇集了一群令人兴奋的年轻调查员 在自己的研究计划中利用先进技术，作为扩大这些技术的结合的机制。 其他TC CFAR成员的研究方法。定制的指导、导航和培训也将 建立和加强伙伴关系和协作。这样，VPC将推进TC的使命 CFAR将促进科学创新，减缓并最终阻止艾滋病毒的流行。

PROJECT SUMMARY THIRD COAST CFAR CORE E: VIRAL PATHOGENESIS CORE (VPC) The Viral Pathogenesis Core (VPC) brings highly sophisticated tools, services and reagents of biological HIV research to the interdisciplinary research teams of the TC CFAR. The largest number of VPC users address Overall aim 3: to discover/develop scientific innovations that better prevent HIV and improve treatment of all conditions for persons living with HIV (PLWH). We provide, and are enhancing, consultation and training to facilitate the ability of our diverse teams spanning the breadth of HIV research disciplines at the University of Chicago and Northwestern University to contribute to development of new biological interventions that will reduce transmission of HIV, address the increased risk of chronic diseases of aging in the HIV+ population, and advance HIV cure research. VPC has already strongly grown opportunities for adding biological tools to the work of clinical and behavioral HIV researchers addressing Overall aims 1 (improving HIV prevention and care continuums) and 2 (non-AIDS co-morbidities). New activities will add engagement of laboratory researchers studying aging biology and aging-related disorders who are interested in collaborations on aging in HIV, in support of Overall aim 2. The specific aims of the VP Core are: 1) provide an expanding menu of virological, imaging and immunological assays, as well as consultation and navigation to other disciplines and technologies, that will advance innovative, interdisciplinary HIV research; 2) provide expert design/performance of HIV experiments, as well as consultation/navigation on imaging, systems biology, -omics; 3) strengthen information exchange and partnerships with other HIV research disciplines and with laboratory / translational researchers new to HIV who are interested in non-AIDS comorbidities. The VPC’s cutting edge tools for studying HIV at the molecular, cell, tissue, and organismal levels include highly sophisticated instrumentation; experienced technical support and customized training; and expert consultation / navigation for new technologies, creative experimental designs and innovative pathogenic hypotheses. A primary objective of the VPC is to make these approaches equally available to the molecular virologist, the clinical/translational researcher, and the behavioral/social scientist. VPC adds value and the necessary rigor in all experimentation, including for projects that previously had limited or no access to approaches such as multiplex biomarker assays and virologic assessments. The Data Insight Group (DIG) is expanding consultation and navigation to specialized multi-omics approaches to studies of this virus, as well. The DIG brings together an exciting group of young investigators utilizing advanced technologies in their own research programs as a mechanism to extend incorporation of these approaches into other TC CFAR members’ research. Customized mentorship, navigation and training will also build and strengthen partnerships and collaborations. In this way, the VPC will advance the mission of the TC CFAR to catalyze scientific innovations that will slow, and eventually stop, the HIV epidemic.