Viral Pathogenesis Core

项目总结 第三海岸CFAR核心E：病毒致病核心(VPC) 病毒致病核心(VPC)带来了高度复杂的生物艾滋病毒工具、服务和试剂 向TC CFAR的跨学科研究团队提供研究。最大数量的VPC用户寻址 总目标3：发现/发展更好地预防艾滋病毒和改善急性淋巴细胞白血病治疗的科学创新 艾滋病毒携带者的条件。我们提供并正在加强咨询和培训，以 促进我们的不同团队在加州大学艾滋病毒研究学科的广泛领域的能力 芝加哥大学和西北大学将为开发新的生物干预措施做出贡献 减少艾滋病毒的传播，解决艾滋病毒人口老龄化慢性病风险增加的问题，以及 推进艾滋病毒治疗研究。VPC已经大力增加了将生物工具添加到工作中的机会 临床和行为艾滋病毒研究人员解决总体目标1(改善艾滋病毒预防和护理 连续体)和2(非艾滋病并存)。新的活动将增加实验室研究人员的参与 研究衰老生物学和与衰老相关的疾病，他们对艾滋病毒的老龄化合作感兴趣，在 支持总体目标2.副总统核心的具体目标是：1)提供扩大的病毒学菜单， 成像和免疫分析，以及咨询和导航到其他学科和技术， 这将推动创新的、跨学科的艾滋病毒研究；2)提供艾滋病毒的专家设计/性能 实验，以及关于成像、系统生物学、组学的咨询/导航；3)加强信息 与其他艾滋病毒研究学科以及实验室/翻译研究人员交流和建立伙伴关系 对非艾滋病并存感兴趣的艾滋病毒新手。VPC用于研究艾滋病毒的尖端工具在 分子、细胞、组织和生物体水平包括高度精密的仪器；经验丰富的技术人员 支持和定制培训；以及新技术的专家咨询/导航、创意 实验设计和创新的致病假说。VPC的主要目标是使这些 分子病毒学家、临床/转化学研究人员和 行为/社会科学家。VPC在所有实验中增加价值和必要的严格性，包括对项目 以前对多重生物标记物分析和病毒学等方法的使用有限或无法使用 评估。Data Insight Group(DIG)正在将咨询和导航扩展到专业的多组学 对这种病毒的研究方法也是如此。这次挖掘汇集了一群令人兴奋的年轻调查人员 在他们自己的研究计划中利用先进技术作为一种机制，扩大这些 其他TC CFAR成员的研究方法。定制的指导、导航和培训也将 建立和加强伙伴关系和协作。这样，VPC将推进TC的使命 CFAR将催化科学创新，从而减缓并最终阻止艾滋病毒的流行。

PROJECT SUMMARY THIRD COAST CFAR CORE E: VIRAL PATHOGENESIS CORE (VPC) The Viral Pathogenesis Core (VPC) brings highly sophisticated tools, services and reagents of biological HIV research to the interdisciplinary research teams of the TC CFAR. The largest number of VPC users address Overall aim 3: to discover/develop scientific innovations that better prevent HIV and improve treatment of all conditions for persons living with HIV (PLWH). We provide, and are enhancing, consultation and training to facilitate the ability of our diverse teams spanning the breadth of HIV research disciplines at the University of Chicago and Northwestern University to contribute to development of new biological interventions that will reduce transmission of HIV, address the increased risk of chronic diseases of aging in the HIV+ population, and advance HIV cure research. VPC has already strongly grown opportunities for adding biological tools to the work of clinical and behavioral HIV researchers addressing Overall aims 1 (improving HIV prevention and care continuums) and 2 (non-AIDS co-morbidities). New activities will add engagement of laboratory researchers studying aging biology and aging-related disorders who are interested in collaborations on aging in HIV, in support of Overall aim 2. The specific aims of the VP Core are: 1) provide an expanding menu of virological, imaging and immunological assays, as well as consultation and navigation to other disciplines and technologies, that will advance innovative, interdisciplinary HIV research; 2) provide expert design/performance of HIV experiments, as well as consultation/navigation on imaging, systems biology, -omics; 3) strengthen information exchange and partnerships with other HIV research disciplines and with laboratory / translational researchers new to HIV who are interested in non-AIDS comorbidities. The VPC’s cutting edge tools for studying HIV at the molecular, cell, tissue, and organismal levels include highly sophisticated instrumentation; experienced technical support and customized training; and expert consultation / navigation for new technologies, creative experimental designs and innovative pathogenic hypotheses. A primary objective of the VPC is to make these approaches equally available to the molecular virologist, the clinical/translational researcher, and the behavioral/social scientist. VPC adds value and the necessary rigor in all experimentation, including for projects that previously had limited or no access to approaches such as multiplex biomarker assays and virologic assessments. The Data Insight Group (DIG) is expanding consultation and navigation to specialized multi-omics approaches to studies of this virus, as well. The DIG brings together an exciting group of young investigators utilizing advanced technologies in their own research programs as a mechanism to extend incorporation of these approaches into other TC CFAR members’ research. Customized mentorship, navigation and training will also build and strengthen partnerships and collaborations. In this way, the VPC will advance the mission of the TC CFAR to catalyze scientific innovations that will slow, and eventually stop, the HIV epidemic.