Qualification and Harmonization of PET/MRI for Cancer Clinical Trials

项目摘要 PET/MRI的主要局限之一是缺乏精确的衰减校正手段， 导致放射性示踪剂摄取的不准确和不一致的定量。PET的不一致性 定量阻止了PET/MRI在临床试验中的广泛采用，在临床试验中， 需要放射性示踪剂摄取的可重复测量。在本申请中，我们建议开发一个 评价基于MR的衰减校正技术和相关PET的标准方法 定量准确性，以使PET/MRI扫描仪有资格用于临床试验和临床工作。这项工作 将在三个具体目标下进行。首先，我们将评估材料，并创建一个物理体模， 评估基于MR的衰减校正技术。我们将在随后验证幻影 使用患者研究来证明我们可以准确地估计测量活动的偏差， 使用PET/MRI体模。最后，我们将协调两个上的重建参数 可用的PET/MRI扫描仪，并评价12个PET/MRI扫描仪的定量准确度的再现性。 MRI研究中心由两家PET/MRI制造商分开。最后，我们将结合PET/MRI 将PET/MRI和PET/CT数据纳入全球统一研究。通过 所描述的工作，我们的目标是创建一个标准化的方法来评估PET的准确性 在PET/MRI环境中进行定量。标准化的方法将激励供应商开发 衰减校正方法，导致系统间更一致的吸收估计， 鉴定扫描仪的能力将有助于将PET/MRI应用于临床试验和临床护理。

Project Summary One of the central limitations of PET/MRI is the lack of accurate means of attenuation correction, which leads to inaccurate and inconsistent quantification of radiotracer uptake. The inconsistency of PET quantification prevents the widespread adoption of PET/MRI in clinical trials, where a precise and reproducible measurement of radiotracer uptake is required. We propose in this application to develop a standard methodology to evaluate MR based attenuation correction techniques and the related PET quantitation accuracy in order to qualify PET/MRI scanners for clinical trials and clinical work. This work will be done in three specific aims. First, we will evaluate materials and create a physical phantom for evaluation of MR based attenuation correction techniques. We will subsequently validate the phantom using a patient study to demonstrate that we can accurately estimate deviations of measured activity using the PET/MRI phantom. Finally, we will harmonize the reconstruction parameters on the two available PET/MRI scanners and evaluate the reproducibility of the quantitative accuracy across 12 PET/ MRI sites split between the two PET/MRI manufacturers. Finally we will incorporate the PET/MRI harmonization data into a global harmonization study that includes both PET/MRI and PET/CT. Through the work described, we aim to create a standardized approach to evaluate the accuracy of PET quantification in the setting of PET/MRI. A standardized methodology will incent vendors to develop attenuation correction methods that result in more consistent uptake estimates across systems, and the ability to qualify scanners will help the adoption of PET/MRI into clinical trials and clinical care.