Developmental Core

项目概要 第三海岸 CFAR 核心 B：发展核心 (DC) 第三海岸艾滋病研究中心 (TC CFAR) 发展核心 (DC) 是 哪些成员建立了由 NIH 资助的新研究，以推进行政核心 (AC) 优先的科学 议程。 DC 服务实现并推动了 TC CFAR 的每一个总体目标。 DC 提供一系列种子 所有教师的资助机制（核心补贴奖）、艾滋病毒研究新教师（试点奖）、我们的 科学核心（核心资源奖）和社区合作伙伴（社区协作和社区 迷你奖）。 DC 在行政补充品 (AS) 竞赛中取得成功，并协助 AC 其他机制。在最初的 5 年里，通过多种 DC 机制发放了超过 560 万美元， AS，其中超过 860,000 美元的资金由 NU 和 UC 提供机构支持。不到5年的时间，回报 这些投资一直很强劲。三个总体目标中每一个目标的项目均由 DC 奖资助 和行政补充；总体目标 2 和 3 最近出现在 AC 主导的战略规划中 高于总体目标 1。这里提出的 DC 工作增加了 DC 资助项目的预期增长，解决总体目标 目标 2 和 3。艾滋病毒研究的新参与者以及向 DC 提交的跨学科材料有所增加。 社区合作奖与 HRSA 资助的社区合作伙伴组织建立了关系， 连同从行政补充提案制定流程中学习，实现了强有力的 响应终结艾滋病毒流行 (EHE) 倡议并成功推出新的 EHE Scientific 工作组开始建立更多的研究实践伙伴关系。强有力的指导是另一个 DC 有助于初级教师职业发展的服务正在芝加哥大学不断发展艾滋病毒研究， 并开始提高 URM 教师在 CFAR 中的代表性。一个新的跨机构、跨领域的 NHLBI 资助的学科职业发展计划（第三海岸 HIV 相关心血管和睡眠 疾病 K12 职业发展计划）正在协同非艾滋病合并症研究的未来发展 以及我们教师的职业生涯。初级教师获得 DC 审查小组的经验，核心人员现在也将获得 指导一位新的联合主任，并为初级教师提供独立的 NIH 资助领导经验 轮值联合董事。 DC 还引导 CFAR 成员获取可增强提案和项目的资源 开发，包括 DC 提交之前和之后的指导以及 NIH 之前的模拟研究部分审查 意见书。此次续约的目的是： (1) 向 TC CFAR 成员提供种子资金，强调尽早 阶段研究人员 (ESI) 并建立了新的艾滋病毒研究人员，以进一步加强高度优先的艾滋病毒研究 研究； (2) 向现有和新的社区合作伙伴提供信息和资金，提供公共卫生、预防和 护理服务，包括消除导致艾滋病毒流行的结构性不平等的服务； (3) 提升事业 开发，并改进对艾滋病毒研究新进入者和我们的提案增强专业知识的导航 科学优先事项。

PROJECT SUMMARY THIRD COAST CFAR CORE B: DEVELOPMENTAL CORE (DC) The Third Coast Center for AIDS Research (TC CFAR) Developmental Core (DC) serves as the foundation from which members build new NIH-funded research that advances the Administrative Core (AC)-prioritized scientific agenda. DC services enable and fuel each of the TC CFAR Overall aims. The DC provides a range of seed funding mechanisms for all faculty (Core Subsidy Awards), faculty new to HIV research (Pilot Awards), our scientific Cores (Core Resource Awards), and community partners (Community Collaborative and Community Mini-Awards). DC has enabled success in competitions for administrative supplements (AS) and assists AC with other mechanisms. In the first 5 years, more than $5.6 million was awarded via multiple DC mechanisms and AS, with >$860,000 of that total contributed by NU and UC from institutional support. In less than 5 years, returns on these investments have been strong. Projects on each of the 3 Overall aims have been funded by DC Awards and Administrative Supplements; Overall aims 2 and 3 emerged from AC-led strategic planning more recently than Overall aim 1. DC work proposed here adds to anticipated growth in DC-funded projects addressing Overall aims 2 and 3. New entrants to HIV research, and trans-disciplinary submissions to the DC, have increased. Community Collaborative Awards built relationships with HRSA-funded community partner organizations that, along with learning from processes for Administrative Supplement proposal development, enabled a strong response to the Ending the HIV Epidemic (EHE) Initiative and the successful launch of new EHE Scientific Working Group that is starting to seed more research-practice partnerships. Strong mentorship is another DC service that contributes to junior faculty career development, is growing HIV research at University of Chicago, and starting to improve representation of URM faculty across the CFAR. A new cross-institutional and cross- disciplinary NHLBI-funded career development program (Third Coast HIV-related Cardiovascular and Sleep Disorders K12 Career Development Program) is synergizing future growth of non-AIDS co-morbidities research as well as our faculty’s careers. Junior faculty gain DC review panel experience, and the Core will now also mentor a new co-director and give junior faculty achieving independent NIH funding leadership experience as a rotating co-director. The DC also navigates CFAR members to resources that enhance proposal and project development, including mentoring before and after DC submissions and mock study section reviews prior to NIH submissions. The aims of this renewal are: (1) to provide seed funding to TC CFAR members, emphasizing early stage investigators (ESI) and established faculty new to HIV research, to further enhance high priority HIV research; (2) to inform and fund current and new community partners providing public health, prevention, and care services, including those countering structural inequities driving the HIV epidemic; (3) to enhance career development, and improve navigation to proposal-enhancing expertise for new entrants to HIV research and our scientific priorities.