Pathogenesis of Rebound SIV/HIV Viremia After Antiretroviral Therapy

项目摘要 这一管理核心的目的是支持高水平的创新和协作，实施 研究团队流程，并承担作为基础设施的行政工作责任 使研究人员能够专注于实现这一项目的科学目标，即 抗逆转录病毒治疗后SIV/HIV病毒血症反弹“。朝着消除 早期停止抗逆转录病毒治疗后艾滋病毒病毒血症的反弹将加速如果实验 PPG的战略被告知并积极更新来自整个国际艾滋病毒的发现 研究努力。我们提出了创造性和可行的机制，以确保我们的 整个PPG团队拥有新的知识，并支持灵活地重新设计适当的实验计划 资源配置。AC的设计使用强大的通信和管理工具 过程的目的是经济高效并预留资源用于 科学项目和非人类灵长类核心。AC将由PPG计划总监Richard博士领导 达奎拉，并将解决以下三个目标：1)建立治理结构，最大限度地促进 研究协作和工作效率，实施有效沟通的流程，并促进 通过关键的、富有成效的外部审查实现卓越，2)确保PPG调查人员在 通过支持通过与艾滋病毒接触而获得信息的实验战略的持续演变来发现 PPG之外的研究进展，以及3)建立有效的行政和财政流程 管理所有绩效站点的PPG资源和工作。空调将使用一位经验丰富的 项目经理、主要调查人员执行委员会和每年召开的科学会议 顾问委员会分别管理、治理和审查PPG。空调将与一个额外的， 使PPG研究保持在发现边缘的创新组件-CORA(临床观察 暂停后反弹)顾问团队。CORA咨询团队(CAT)将把领导者聚集在一起 来自美国军方艾滋病毒研究计划，调查泰国人类队列的早期感染(RV 254/搜索010研究)，来自芝加哥不同机构的临床医生和临床研究人员走在了前列 以回顾艾滋病治疗和病毒血症反弹研究中的最新信息 并计划在PPG的第4-5年进行一项人类飞行员的观察性研究。PPG科学团队的AC支持 而CAT将通过加强整合，促进 通信，高效地提供管理服务，并降低组织障碍以实现 研究人员以富有成效和互动的方式推进这一计划的科学目标。

Project Summary The purpose of this administrative core is to support high levels of innovation and collaboration, implement research team processes, and assume responsibility for administrative work as the foundational infrastructure enabling the investigators to focus on achieving the scientific goals of this program project, "Pathogenesis of Rebound SIV/HIV Viremia after Antiretroviral Therapy". Progress toward the ultimate goal of eliminating rebound of HIV viremia after stopping early antiretroviral therapy will be accelerated if the experimental strategies of this PPG are informed and actively updated of discoveries from the entire, international HIV research effort. We have proposed creative and feasible mechanisms to assure the active engagement of our entire PPG team with new knowledge and to support nimble re-design of experimental plans with appropriate allocation of resources. The design of the AC uses robust tools for communications and administrative processes with the intent to be economically efficient and reserve resources for experimentation in the scientific projects and non-human primate core. The AC will be led by the PPG Program Director, Dr. Richard D'Aquila, and will address the following three aims: 1) Establish governance structures facilitating maximum research collaboration and productivity, implement processes for effective communications, and promote excellence via critical, productive external review, 2) Assure that PPG investigators function at the edge of discovery by supporting continual evolution of experimental strategy informed by engagement with HIV research advances outside the PPG, and 3) Establish efficient processes for administrative and fiscal management of PPG resources and effort across all performance sites. The AC will use an experienced Program Manager, an Executive Committee of the principal investigators, and an annually-convened Scientific Advisory Board to manage, govern, and review the PPG, respectively. The AC will work with an additional, innovative component to keep PPG research at the edge of discovery - the CORA (Clinical Observation of Rebound after pausing ART) Advisory Team. The CORA Advisory Team (CAT) will bring together leaders from the US Military HIV Research Program investigating early infection in a human cohort in Thailand (the RV 254/SEARCH 010 study), clinicians and clinical investigators from diverse Chicago institutions at the forefront of HIV care, and patients in order to review the newest information in HIV cure and viremia rebound research and plan a human pilot, observational study in years 4-5 of this PPG. AC support of the PPG scientific team and the CAT will accelerate the pace of scientific discovery by strengthening integration, promoting communications, efficiently delivering administrative services, and lowering organizational barriers to allow investigators to productively and interactively advance the scientific aims of this program.