Northwestern University Clinical and Translational Science Institute (NUCATS)

联系PD/PI：Lloyd-Jones，Donald M 抽象的。西北大学临床与翻译科学研究所(NUCATS)担任 在三个不同的规模上推进临床和转化科学(CTS)的综合枢纽：本地、在 西北大学(NU)和我们的3个全国知名的临床合作伙伴；在地区上，横跨芝加哥和 与其他两个芝加哥CTSA中心和我们的许多社区利益攸关方合作；以及 在全国范围内，通过我们积极参与CTSA联盟。通过利用持续的CTSA资金 自2008年以来，由于NU和我们的合作伙伴提供了大量的财政和实物支持，NUCATS 在所有三个规模上都取得了成功，发展成为一个成熟、平衡、高度运作的CTSA，拥有广泛的产品组合 从T0到T4的前沿项目。展望未来，我们认识到继续存在 成为令人兴奋的创新和改进的战略机遇，NUCATS不怕试验 以实现我们的使命，加快对患者和 人口，以改善人类健康。我们将通过五个基础广泛的全球 目标，重点是：扩大和进一步将研究纳入临床护理系统和 过程，最终目标是每一次临床接触都可以成为参与研究的机会， 精准医疗和学习改善所有人的健康；加快地方、地区和国家的CTS 通过增强我们现有的集成数字研究基础设施来开发和应用新的、领先的 信息学和数据科学工具可促进研究、教育、协作、参与、评估和 传播；扩大我们的社区和利益相关者的参与，并推动团队科学，以实现 高功能、利益相关者参与的多学科研究团队，在整个 CTS的范围；开发、示范、传播和采用创新和可持续的CTS 加速翻译的方法和过程，并培养严谨、可重复性、评估和 在CTSA联盟中持续改进；以及创新、测试和传播 培训计划，培养、装备和增强未来多样化的翻译研究队伍。 我们建议利用CTSA资金解决CTS的关键战略机遇和关键障碍，而不是 只在NUCATS，但在芝加哥和CTSA财团。在这样做时，我们预计NUCATS 将继续在CTSA计划不断演变的过程中发挥核心作用，加速CTS实现 改善人类健康。 第236页 项目摘要/摘要 联系PD/PI：Lloyd-Jones，Donald M

Contact PD/PI: LLOYD-JONES, DONALD M ABSTRACT. The Northwestern University Clinical and Translational Sciences Institute (NUCATS) serves as an integrated hub to advance Clinical and Translational Science (CTS) at three distinct scales: locally, at Northwestern University (NU) and our 3 nationally-renowned clinical partners; regionally, across Chicago and in collaboration with the other two Chicago CTSA hubs and our many community stakeholder partners; and, nationally, through our active participation in the CTSA Consortium. By leveraging continuous CTSA funding since 2008, as well as substantial financial and in-kind support from NU and our partners, NUCATS has succeeded at all three scales, evolving into a mature, balanced, highly-functioning CTSA with a broad portfolio of leading-edge programs spanning T0 through T4. Looking to the future, we recognize that there continue to be exciting strategic opportunities for innovation and improvement, and NUCATS is not afraid to experiment upon itself to achieve our mission of speeding transformative research discoveries to patients and the population, in order to improve human health. We will build on this legacy through five broad-based Global Objectives, which focus on: expanding and further integrating research into clinical care systems and processes, with the ultimate goal that every clinical encounter can be an opportunity for research participation, precision medicine, and learning to improve human health for all; accelerating local, regional, and national CTS by enhancing our existing integrated digital research infrastructure to develop and apply new, leading-edge informatics and data science tools to catalyze research, education, collaboration, engagement, evaluation, and dissemination; broadening our community and stakeholder engagement and advance team science to enable high-functioning, stakeholder-engaged, multi-disciplinary research teams that have impact across the spectrum of CTS; developing, demonstrating, disseminating, and adopting innovative and sustainable CTS methods and processes to accelerate translation and foster a culture of rigor, reproducibility, evaluation, and continuous improvement across the CTSA consortium; and innovating, testing, and disseminating novel training programs to cultivate, equip, and empower the diverse translational research workforce of tomorrow. We propose to leverage CTSA funding to address key strategic opportunities and critical barriers to CTS, not only at NUCATS, but across Chicagoland and the CTSA consortium. In doing so, we anticipate that NUCATS will continue be a central player in the ongoing evolution of the role of CTSA Program in accelerating CTS to improve human health. Page 236 Project Summary/Abstract Contact PD/PI: LLOYD-JONES, DONALD M