Training Grant in Pediatric Endocrinology, Diabetes and Metabolism

项目摘要 此更新申请要求继续支持我们的NIH机构培训补助金（T32）在儿科 内分泌学在哥伦比亚大学，Vagelos医师和外科医生学院（CUIMC）。这笔赠款将允许 儿科内分泌科继续1）加强和发展研究培训机会， 儿科内分泌学2）满足培训儿科内分泌学研究者的国家优先事项，这些研究者将 可在实验室、临床和转化研究中担任领导角色3）创建骨干 儿科内分泌学家的未来学术生涯将有助于填补研究人员的严重短缺， 儿童糖尿病/肥胖症和4）准备研究人员，以满足持续的国家卫生优先事项/目标 包括糖尿病、母婴和儿童健康以及超重/代谢紊乱。这些目标是 通过在ACGME批准的儿科内分泌学奖学金中完成三年的培训来实现。 此外，选定的研究员将有资格参加肥胖医学委员会。 调查的五个方面是i.肥胖/临床和分子糖尿病，ii.相互关系和疾病 雄激素/生长因子/脂质代谢，iii.身体成分和代谢性骨病，iv。 环境内分泌干扰物和v.个性化医疗/遗传学/细胞生物学，与儿科相关 内分泌科该计划包括生物统计学，信息学，流行病学，代谢组学和生物统计学方面的培训。 微生物学，伦理学和人类研究，赠款写作，药代动力学，分子和细胞生物学， 需要教学课程和职业指导。34名培训教师包括30名科学教师。 导师，4名咨询教师，1名生物统计学家/流行病学家，1名儿科研究副院长和1名 教师发展副主席，都来自多个相互关联的部门。 该机构对研究的承诺体现在哥伦比亚被指定为刚果民主共和国并拥有 获得了CTSA授予的转化研究的原始资金。这个应用程序是由一个NIH 支持CTSA，在以患者为导向的研究和临床研究方法和CTSA硕士课程 支持KL 2辅导职业发展计划和试点CTSA奖项。CUIMC致力于 招聘妇女和少数族裔申请人以及职业发展。这一要求是为了继续 每年资助3个研究金受训人员职位，为期5年。多亏了这个培训补助金和强大的 我们已经制定了计划，我们继续招募优秀的申请人谁已经完成了儿科 住院医师，并寻求发展他们的研究技能，儿科内分泌学和糖尿病。

PROJECT SUMMARY This renewal application requests continued support of our NIH Institutional training grant (T32) in Pediatric Endocrinology at Columbia University, Vagelos College of Physicians & Surgeons (CUIMC). This grant will allow the Division of Pediatric Endocrinology to continue to 1) enhance and develop research training opportunities in pediatric endocrinology 2) meet the national priorities of training investigators in pediatric endocrinology who will be available to assume leadership roles in laboratory, clinical and translational based research 3) create a cadre of pediatric endocrinologists whose future academic careers will help fill the critical shortage of investigators in pediatric diabetes/obesity and 4) prepare investigators to meet the continuing national health priorities/objectives including Diabetes, Maternal Infant and Child Health, and Overweight/Metabolic Disorders. These goals are achieved by completion of three years of training in our ACGME approved Pediatric Endocrinology fellowship. In addition, select fellows will be qualified to sit for the Obesity Medicine Boards. The five areas of investigation are i. Obesity/Clinical and Molecular Diabetes, ii. Interrelationships and Disorders of Androgen/Growth Factors/Lipid Metabolism, iii. Body Composition and Metabolic Bone Disease, iv. Environmental Endocrine Disruptors and v. Personalized Medicine/Genetics/Cell Biology, as related to Pediatric Endocrinology. The program includes training in biostatistics, informatics, epidemiology, metabolomics/ microbiomics, ethics and human research, grant writing, pharmacokinetics, molecular and cellular biology with required didactic coursework and career guidance. The 34 training faculty preceptors include 30 scientific mentors, 4 consultative faculty, 1 biostatistician/epidemiologist, 1 Associate Dean of Pediatric Research and 1 Vice Chair of Faculty Development, all from multiple interrelated divisions. The institution’s commitment to research is exemplified by Columbia having been designated a DRC and having received an original CTSA grant for translational research. This application is augmented thus by an NIH supported CTSA, a Master’s Program in Patient Oriented Research and Clinical Research methods and a CTSA supported KL2 Mentored Career Development Program and pilot CTSA awards. CUIMC is committed to the recruitment of women and minority applicants and career development. This request is made for continued funding of 3 fellowship trainee positions per year for a 5 year award. Thanks to this training grant and the strong program we have developed, we continue to recruit outstanding applicants who have completed their pediatric residency and seek to develop their research skills in Pediatric Endocrinology and Diabetes.