Training Grant in Pediatric Endocrinology, Diabetes and Metabolism

儿科内分泌、糖尿病和代谢培训补助金

• 批准号: 8075946
• 负责人: SHARON E. OBERFIELD
• 金额: $ 2.85万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8075946
• 关键词: Childhood; Diabetes Mellitus; Endocrinology; Grant; Metabolism; Training

DESCRIPTION (provided by applicant): This renewal application requests continued support of our NIH Institutional training grant (T32) in Pediatric Endocrinology at Columbia University, College of Physicians & Surgeons (CUMC). This grant will allow the Division of Pediatric Endocrinology to continue to 1) enhance and develop research training opportunities in pediatric endocrinology 2) meet the national priorities of training investigators in pediatric endocrinology who will be available to assume leadership roles in clinical/laboratory based research 3) create a cadre of pediatric endocrinologists whose future academic careers will help fill the critical shortage of investigators in pediatric diabetes/obesity and 4) prepare investigators to meet the continuing national health priorities/objectives including Diabetes, Maternal Infant and Child Health, and Overweight. These goals are achieved by completion of three years of training in our ACGME approved Pediatric Endocrinology fellowship. Funding is requested only for the two years devoted to research in fields relevant to pediatric endocrinology. The five areas of investigation are Clinical and Molecular Diabetes/Obesity, Interrelationships and Disorders of Androgen/Growth Factors/Lipid Metabolism, Neuroendocrinology, Body Composition and Metabolic Bone Disease, and Genetics/Cell Biology, as related to Pediatric Endocrinology. The program includes training in biostatistics, epidemiology, ethics and human research, grant writing, pharmacokinetics, molecular and cellular biology, with required didactic coursework. The training faculty includes 22 scientific mentors, 11 consultative faculty, 1 biostatistician/epidemiologist, and 1 Associate Dean of Pediatric Research, all from multiple interrelated divisions. The institution's commitment to research is exemplified by Columbia having been designated a DERC, and having received an original CTSA grant for translational research. This application is augmented by an NIH supported GCRC, a Masters Program in Patient Oriented Research and Clinical Research Methods, and a CTSA supported K12 Mentored Career Development Program. CUMC is committed to the recruitment of women and minority applicants. This request is made for continued funding of 3 fellowship trainee positions per year for a 5 year award. RELEVANCE (See instructions): More physician scientists are needed to define the pathophysiology of Pediatric Endocrine disease and to allow for the development of new treatments. Unfortunately, the number of T32 training grants in Pediatric Endocrinology remains limited. Although our program is young, our graduates have begun to fill voids and assume academic leadership roles in pediatric endocrinology in order to better understand and ultimately cure disorders targeted as national public health priorities, including pediatric diabetes and obesity.

描述(由申请人提供)：此续签申请请求继续支持我们在哥伦比亚大学内外科医学院(CUMC)的儿科内分泌学方面的NIH机构培训补助金(T32)。这笔赠款将使儿科内分泌科能够继续1)加强和发展儿科内分泌学方面的研究培训机会，2)满足儿科内分泌学培训研究人员的国家优先事项，他们将能够在临床/实验室研究中担任领导角色3)培养一支儿科内分泌科专家队伍，他们未来的学术生涯将有助于填补儿科糖尿病/肥胖症研究人员的严重短缺，4)培养研究人员，以满足持续的国家健康优先/目标，包括糖尿病、母婴健康和超重。这些目标是通过在我们ACGME批准的儿科内分泌学奖学金中完成三年的培训来实现的。只要求为与儿科内分泌学相关领域的研究提供两年的资金。这五个研究领域是与儿科内分泌学有关的临床和分子糖尿病/肥胖、雄激素/生长因子/脂代谢的相互关系和紊乱、神经内分泌学、身体成分和代谢性骨骼疾病以及遗传学/细胞生物学。该计划包括生物统计学、流行病学、伦理学和人类研究、拨款撰写、药物动力学、分子和细胞生物学方面的培训，以及必修的教学课程。培训教师包括22名科学导师、11名咨询教师、1名生物统计学家/流行病学家和1名儿科研究副院长，他们都来自多个相互关联的部门。哥伦比亚大学被指定为DERC，并获得了CTSA最初的翻译研究拨款，这证明了该机构对研究的承诺。这一应用程序由NIH支持的GCRC、以患者为导向的研究和临床研究方法方面的硕士计划以及CTSA支持的K12导师职业发展计划加强。CUMC致力于招聘女性和少数族裔申请者。这项请求是为了继续为每年3个研究金受训人员职位提供经费，用于5年期奖励。相关性(见说明)：需要更多的内科科学家来定义儿科内分泌疾病的病理生理学，并允许开发新的治疗方法。不幸的是，儿科内分泌学T32培训赠款的数量仍然有限。虽然我们的项目还很年轻，但我们的毕业生已经开始填补儿科内分泌学的空白，并承担起学术领导的角色，以便更好地了解并最终治愈作为国家公共卫生优先事项的疾病，包括儿科糖尿病和肥胖症。