PRANAYAMA BASED GROUP VIDEO APP FOR CANCER SURVIVORSHIP. Phase I. Breast Cancer Pilot

项目总结 癌症仍然是美国第二大死亡原因。令人鼓舞的是，最近早期癌症的改善 诊疗使癌症患者的存活率显著提高。作为癌症 成为一种慢性但可控的疾病，对成千上万的幸存者来说，长期的生理和心理上的 治疗方案的副作用变得越来越明显，这些问题对无病的影响也是如此 或总体存活率。作为这种不断变化的格局的结果，生存护理计划和方法 融入非药理学的生活方式和身心干预正变得越来越重要 患者治疗路径的组成部分。在这方面，冥想和瑜伽，如瑜伽 呼吸(YB)，一种自愿调节呼吸的技术的集合，已经成为一种有效的 癌症患者的补充治疗。YB是公认的通过以下方式诱导强烈松弛反应的药物 迷走神经和副交感神经刺激。在这项申请中，PranaScience试图开发一种新的群体视频 针对YB应用程序进行了优化，可在家中交付最有效的被禁YB计划 减少与癌症治疗和生存相关的症状。这一干预是基于 PI对这项提案进行了令人信服的初步研究，证明了特定的YB练习 诱导与肿瘤抑制、免疫调节、 神经调节和应激反应/炎症，以及与 南卡罗来纳医科大学(MUSC)表示，癌症幸存者对YB干预感兴趣 并在YB课程后感受到幸福感的改善。在这一阶段，PranaScience将(1)建立一个 第一个团体视频YB应用程序的生产版本和(2)与MUSC合作在乳房试行YB应用程序 癌症幸存者评估该应用程序支持症状的依从性、可行性和可接受性 管理层。将收集应用程序使用数据，并用于评估对该计划的遵守情况和可接受性 将使用一系列已定义的生物行为测量在基线和 在12周的实施期之后。专注于唾液和指甲生物标志物的探索性分析 将进行肿瘤抑制、炎性细胞因子、蛋白质组水平改变和应激激素的研究。 在基线和第12周。对研究参与者的有组织的、有重点的访谈将用于评估技术 感知/计划的可行性，并将为未来的设计优化提供信息。此第一阶段计划的结果 将综合提炼群视YB APP，为二期大规模测评做准备， 最终形成一种可扩展的低成本资源，可加速从治疗中恢复并支持 全部位癌症幸存者的可持续健康，并承诺适应其他慢性护理环境。

PROJECT SUMMARY Cancer remains the second leading cause of deaths in the U.S. Encouragingly, recent improvements in early diagnosis and treatment has led to significant increases in the survival rate of cancer patients. As cancer becomes a chronic but manageable disease for thousands of survivors, the long-term physical and psychological side effects of treatment protocols is becoming more apparent, as is the impact of these issues on disease-free or overall survival. As a result of this changing landscape, survivorship care programs and approaches that incorporate non-pharmacological lifestyle and mind-body interventions are becoming increasingly critical components of the patient treatment pathway. In this regard, aspects of meditation and yoga such as yogic breathing (YB), a collection of techniques to voluntarily regulate breathing, has emerged as an effective complementary therapy for cancer patients. YB is well-established to induce strong relaxation responses via vagal and parasympathetic stimulation. In this application, PranaScience seeks to develop a novel group video app for YB that is optimized for home-based delivery of a proscribed YB program that is maximally effective in reducing symptomatic conditions associated with cancer treatment and survival. This intervention is based on compelling preliminary studies conducted by the PI of this proposal demonstrating that specific YB exercises induce alterations in the levels of proteins associated with tumor suppression, immune regulation, neuromodulation, and stress response/ inflammation, as well as pilot studies performed in collaboration with the Medical University of South Carolina (MUSC) indicating that cancer survivors are interested in a YB intervention and perceive improvements in well-being after YB sessions. In this Phase I STTR, PranaScience will (1) build a first production version of a group video YB app and (2) partner with MUSC to pilot test the YB app in breast cancer survivors to evaluate adherence, feasibility, and acceptability of the app to support symptom management. App usage data will be collected and used to evaluate adherence to the program, and acceptability for symptom management will be evaluated using a series of defined biobehavioral measures at baseline and following a 12-week implementation period. Exploratory salivary and fingernail biomarker analysis focused on tumor suppressors, inflammatory cytokines, proteome level alterations, and stress hormones will be performed at baseline and at week 12. Structured, focused interviews of study participants will be used to assess technology perception/ program feasibility and will inform future design optimizations. Findings from this Phase I program will be synthesized to refine the group video YB app in preparation for large-scale evaluation in Phase II, ultimately resulting in a scalable, low-cost resource that accelerates recovery from treatment and supports sustainable health in all-site cancer survivors, with a promise for adaptation to other chronic care settings.