PRANAYAMA BASED MOBILE APP FOR BREAST CANCER SURVIVORSHIP: I-CORPS SUPPLEMENT

基于调息的乳腺癌幸存者移动应用程序：I-CORPS 补充品

• 批准号: 10558811
• 负责人: SUNDARAVADIVEL BALASUBRAMANIAN
• 金额: $ 5.5万
• 依托单位: PRANASCIENCE INSTITUTE LLC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10558811
• 关键词: Adherence; American Cancer Society; Antineoplastic Protocols; Behavioral; Biological Markers; Breast Cancer survivor; Breast Cancer survivorship; Breathing; Breathing Exercises; COVID-19 pandemic; Cancer Etiology; Cancer Patient; Cancer Survivor; Cancer Survivorship; Caregivers; Caring; Cause of Death; Cessation of life; Chronic; Collection; Communities; Complementary therapies; Computer software; Control Groups; Custom; Data; Development; Disease; Disease Management; Early Diagnosis; Early treatment; Equipment and supply inventories; Evaluation; Evidence based intervention; Exertion; Fibrinogen; Focus Groups; Frequencies; Funding; Future; Gene Expression; General Population; Goals; Group Interviews; Health; Home; Hormones; Individual; Inflammation; Inflammatory; Innovation Corps; Institutes; Integrative Medicine; Intervention; Interview; Length; Life; Life Style; Link; Lung; Malignant Neoplasms; Measures; Medical; Meditation; Mental Depression; Metabolism; Methods; Mind-Body Intervention; Modality; Online Systems; Outcome; Participant; Pathway interactions; Patient Self-Report; Patients; Perception; Personal Satisfaction; Phase; Pilot Projects; Preparation; Production; Program Acceptability; Proteins; Proteome; Psychological Side Effects; Quality of life; Radiation therapy; Randomized; Rehabilitation therapy; Relaxation; Resources; Risk; Salivary; Secondary to; Series; Small Business Technology Transfer Research; Social Distance; South Carolina; Stress; Structure; Structure of nail of finger; Supportive care; Surveys; Survival Rate; Survivors; Symptoms; System; Techniques; Technology; Testing; Time; Treatment Protocols; Treatment Side Effects; Tumor Suppression; Tumor Suppressor Proteins; Universities; Virtual Tool; Visual; Visual Aid; Woman; Work; Yoga; attentional control; base; biobehavior; biological adaptation to stress; cancer site; cancer therapy; cognitive process; cohort; commercialization; cytokine; design; ethnic minority; evidence base; healthy lifestyle; healthy volunteer; immunoregulation; improved; interest; intervention delivery; malignant breast neoplasm; mobile application; neuroregulation; novel; peer support; perceived stress; pilot test; pranayama; programs; racial minority; response; rural area; satisfaction; side effect; survivorship; symptom management; telehealth; tool; tumor; usability

PROJECT SUMMARY Cancer remains the second leading cause of deaths in the U.S. Encouragingly, recent improvements in early diagnosis and treatment has led to significant increases in the survival rate of cancer patients. As cancer becomes a chronic but manageable disease for thousands of survivors, the long-term physical and psychological side effects of treatment protocols is becoming more apparent, as is the impact of these issues on disease-free or overall survival. As a result of this changing landscape, survivorship care programs and approaches that incorporate non-pharmacological lifestyle and mind-body interventions are becoming increasingly critical components of the patient treatment pathway. In this regard, integrative approaches such as yogic breathing (YB), a collection of techniques to voluntarily regulate breathing, have emerged as an effective complementary therapy for cancer patients. YB is well-established to induce strong relaxation responses via vagal and parasympathetic stimulation. YB is easy to practice using virtual tools such as mobile apps especially during the current scenario of COVID-19 pandemic and social distancing. In this application, PranaScience seeks to develop a novel group video app for YB that is optimized for home-based delivery of a proscribed YB program that is maximally effective in promoting peer support, and relieving symptomatic conditions associated with cancer treatment and survivorship. This intervention is based on compelling preliminary data generated by the PI of this proposal demonstrating that specific YB exercises induce alterations in the levels of proteins associated with tumor suppression, immune regulation, neuromodulation, and stress response/ inflammation, as well as pilot studies performed in cancer survivors and other patient/general populations indicating that participants are interested in a YB intervention and perceive improvements in well-being after YB sessions. In this Phase I STTR, PranaScience (1) has built a first production version of a culturally neutral group video YB app and (2) partners with the Medical University of South Carolina (MUSC) to pilot test the YB app in breast cancer survivors to evaluate adherence, feasibility, and acceptability of the app to support symptom management. App usage data is collected and used to evaluate adherence to the program, and acceptability for symptom management will be evaluated using a series of defined biobehavioral measures at baseline and following a 12-week implementation period. Exploratory salivary and fingernail biomarker analysis focused on tumor suppressors, inflammatory cytokines, proteome level alterations, and stress hormones will be performed at baseline and at week 12. Structured, focus group interviews of study participants will be used to assess technology perception/ program feasibility and will inform future design optimizations. Information from the I-Corps supplemental work will be used to refine app in preparation for large-scale evaluation in Phase II, and for commercialization purposes through customer discovery interviews.

项目概要 癌症仍然是美国第二大死亡原因。令人鼓舞的是，早期癌症治疗方面的最新进展 诊断和治疗使癌症患者的生存率显着提高。作为癌症 对于成千上万的幸存者来说，这种疾病已成为一种慢性但可控制的疾病，长期的身体和心理负担 治疗方案的副作用变得越来越明显，这些问题对无病患者的影响也越来越明显 或总体生存率。由于这种不断变化的形势，幸存者护理计划和方法 结合非药物生活方式和身心干预变得越来越重要 患者治疗途径的组成部分。在这方面，瑜伽呼吸等综合方法 （YB）是一系列自愿调节呼吸的技术，已成为一种有效的补充 癌症患者的治疗。 YB 可以通过迷走神经和神经系统诱导强烈的放松反应 副交感神经刺激。 YB 很容易使用虚拟工具（例如移动应用程序）进行练习，尤其是在 COVID-19 大流行和社会疏远的当前情况。在此应用中，PranaScience 力求 为 YB 开发一款新颖的群组视频应用程序，该应用程序针对受禁 YB 节目的家庭交付进行了优化 这在促进同伴支持和缓解与 癌症治疗和生存。该干预措施基于以下机构生成的令人信服的初步数据： 该提案的 PI 证明特定的 YB 练习会引起相关蛋白质水平的变化 具有肿瘤抑制、免疫调节、神经调节、应激反应/炎症以及 在癌症幸存者和其他患者/一般人群中进行的试点研究表明，参与者 对 YB 干预感兴趣，并认为 YB 课程后幸福感有所改善。在第一阶段 STTR 中， PranaScience (1) 构建了文化中立的团体视频 YB 应用程序的第一个生产版本和 (2) 合作伙伴 与南卡罗来纳医科大学 (MUSC) 合作，在乳腺癌幸存者中对 YB 应用程序进行试点测试 评估该应用程序的依从性、可行性和可接受性，以支持症状管理。应用程序使用数据 收集并用于评估对计划的遵守情况，症状管理的可接受性将 在基线和 12 周实施后使用一系列定义的生物行为测量进行评估 时期。探索性唾液和指甲生物标志物分析，重点关注肿瘤抑制因子、炎症因子 将在基线和第 12 周进行细胞因子、蛋白质组水平变化和应激激素检查。 研究参与者的结构化焦点小组访谈将用于评估技术认知/计划 可行性并将为未来的设计优化提供信息。来自 I-Corps 补充工作的信息将 用于完善应用程序，为二期大规模评估做准备，并用于商业化目的 通过客户发现访谈。

项目成果

A quality improvement study on the feasibility and potential benefits of a yogic breathing program for cancer survivors and caregivers during treatment in a lodging facility.

一项关于癌症幸存者和护理人员在住宿设施治疗期间进行瑜伽呼吸计划的可行性和潜在益处的质量改进研究。

• DOI: 10.1016/j.bbii.2023.100019
• 发表时间: 2023
• 期刊: Brain behavior and immunity integrative
• 作者: Alford,ChristinaM;Wahlquist,AmyE;Sterba,KatherineR;Warren,GrahamW;Balasubramanian,Sundaravadivel
• 通讯作者: Balasubramanian,Sundaravadivel