Pediatric Paracorporeal and Extracorporeal Therapies (PPET) Summit 2021

2021 年儿科体外和体外治疗 (PPET) 峰会

• 批准号: 10156359
• 负责人: Ayse Akcan Arikan
• 金额: $ 7.5万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-07 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10156359
• 关键词: Acute; Acute Liver Failure; Acute Renal Failure with Renal Papillary Necrosis; Address; Adult; Adult Respiratory Distress Syndrome; Albumins; American; Area; Blood Component Removal; Caregivers; Caring; Child; Child Care; Child Support; Childhood; Childhood Injury; Clinical; Collaborations; Communities; Complex; Consensus; Critical Care; Critical Illness; Critically ill children; Data; Devices; Dialysis procedure; Drug Kinetics; Education; Educational workshop; Ethics; Evidence based practice; Extracorporeal Membrane Oxygenation; Face; Failure; Family; Fostering; Future; Goals; Guidelines; Heart-Lung Transplantation; Home; Hospitals; Hybrids; Individual; Institution; International; Knowledge; Learning; Life; Liver; Maps; Medical Care Team; Medical Device; Medicine; Modality; Multiple Organ Failure; National Institute of Child Health and Human Development; Organ; Organ failure; Outcome; Patient Care; Patients; Pediatric Intensive Care Units; Persons; Physiological; Plasmapheresis; Publications; Quality of Care; Recovery; Renal Replacement Therapy; Research; Resources; Resuscitation; Role; Series; Shapes; Societies; Standardization; Structure; Technology; Terminology; Time; Transplantation; Variant; Work; advanced system; base; body system; clinical care; expectation; experience; improved; improved outcome; innovation; medical specialties; meetings; multimodality; novel; pediatric patients; prospective; symposium; ventricular assist device; virtual; working group

Project Summary Pediatric paracorporeal and extracorporeal therapies (PPET) are increasingly applied to support children with multiple organ failure (MOF). These highly complex, resource intensive technologies lie at the interface of innovation and the highest complexity clinical care; in patients with MOF, multiple treatment modalities are frequently used simultaneously. However, lack of clinical guidelines or consensus statements to guide PPET use result in a lack of standardization of practice, compounded by limited dialogue between experts and institutions regarding PPET use, in particular in the application of multiple PPET modalities. Children are further disenfranchised due to the lack of medical devices optimized for the varied size and physiological differences in pediatric practice. There is a critical need for collaborative initiatives aimed at standardization of practice, quality improvement, research and innovation as they relate to the applications of PPET. The PPET Summit 2021 will transform these critical gaps into knowledge and research opportunities by bringing together, for the first time, pediatric and adult experts from across the globe in the fields of extracorporeal membrane oxygenation, ventricular assist device, renal replacement therapy, extracorporeal liver support, and apheresis. The Summit will bring together local and international experts to define the current status of PPET, including the role of hybrid and tandem therapies; standardize current approaches; identify key knowledge gaps that need to be addressed to facilitate optimal patient care, and set a collaborative research and quality agenda to improve our understanding of PPET. This will provide an exciting and much needed framework to optimize the care of these patients and improve their outcomes. Preconference working groups, led by experts selected by the diverse organizing committee around the core domains ((1) patient and family experiences and outcomes; (2) pharmacokinetics; (3) standardization of terminology and quality metrics; (4) innovation; (5) ethics; (6) circuit and organ interactions and cross-talk) will work in a series of highly structured virtual workshops to maximize global participation in the months prior to the Summit to generate consensus statements. The Summit itself will include state of-the-art presentations from the experts to define the current status, underlining the importance of cross-pollination of multiple therapies and approaches. On the final day, a session entitled `Map the Future' will bring together summaries from the pre-conference workshops with all attendees to refine research imperatives for PPET initiatives, including discussion of potential future summits. The proceedings of the first PPET Summit will be disseminated as a series of leading articles in Critical Care and Resuscitation.

项目概要 儿科体外和体外治疗 (PPET) 越来越多地应用于支持 患有多器官衰竭（MOF）的儿童。这些高度复杂、资源密集型的技术 处于创新和最复杂的临床护理的交汇处； MOF 患者， 多种治疗方式经常同时使用。但临床缺乏 指导 PPET 使用的指南或共识声明导致缺乏标准化 实践，再加上专家和机构之间关于 PPET 使用的有限对话， 特别是在多种 PPET 模式的应用中。儿童的权利被进一步剥夺 由于缺乏针对不同尺寸和生理差异进行优化的医疗设备 儿科实践。迫切需要旨在标准化的协作举措 与 PPET 应用相关的实践、质量改进、研究和创新。 2021 年 PPET 峰会将把这些关键差距转化为知识和研究 首次汇集来自世界各地的儿科和成人专家 体外膜氧合、心室辅助装置、肾功能领域的全球 替代疗法、体外肝脏支持和血浆分离术。此次峰会将汇聚 本地和国际专家定义 PPET 的现状，包括混合动力的作用 和串联疗法；标准化当前方法；确定需要的关键知识差距 旨在促进最佳的患者护理，并建立协作研究和质量 议程以提高我们对 PPET 的理解。这将提供一个令人兴奋且急需的 框架来优化这些患者的护理并改善他们的结果。 会前工作组，由不同组委会选出的专家领导 围绕核心领域（(1) 患者和家属的经历和结果；(2) 药代动力学； (3) 术语和质量指标的标准化； （4）创新； （五）道德规范； (6)电路和 器官相互作用和串扰）将在一系列高度结构化的虚拟研讨会中进行 在峰会前几个月最大限度地提高全球参与度以达成共识 声明。峰会本身将包括专家们的最先进的演讲，以定义 当前的状况，强调了多种疗法异花授粉的重要性， 接近。最后一天，题为“绘制未来”的会议将汇总总结 来自与所有与会者的会前研讨会，以完善 PPET 的研究必要性 倡议，包括讨论未来可能举行的峰会。首届 PPET 会议进程 峰会将作为重症监护和复苏领域的一系列领先文章进行传播。

项目成果

Cefepime Dosing in a Critically Ill Neonate Receiving Continuous Renal Replacement Therapy With the Cardio-Renal Pediatric Dialysis Emergency Machine (CARPEDIEM).

使用心肾小儿透析急救机 (CARPEDIEM) 接受连续肾脏替代治疗的危重新生儿的头孢吡肟剂量。

• DOI: 10.5863/1551-6776-28.2.167
• 发表时间: 2023
• 期刊: The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
• 作者: Toy,Cynthia;Stimes,Grant;Moore,Megan;Srivaths,Poyyapakkam;Arikan,AyseAkcan
• 通讯作者: Arikan,AyseAkcan

Clearance and nutrition in neonatal continuous kidney replacement therapy using the Carpediem™ system.

使用 Carpediem™ 系统进行新生儿连续肾脏替代治疗的清除和营养。

• DOI: 10.1007/s00467-023-06237-w
• 发表时间: 2024
• 期刊: Pediatric nephrology (Berlin, Germany)
• 作者: Vuong,KimT;Vega,MollyR;Casey,Lauren;Swartz,SarahJ;Srivaths,Poyyapakkam;Osborne,ScottW;Rhee,ChristopherJ;Arikan,AyseAkcan;Joseph,Catherine
• 通讯作者: Joseph,Catherine