Pediatric Paracorporeal and Extracorporeal Therapies (PPET) Summit 2021

2021 年儿科体外和体外治疗 (PPET) 峰会

• 批准号: 10156359
• 负责人: Ayse Akcan Arikan
• 金额: $ 7.5万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-07 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10156359
• 关键词: Acute; Acute Liver Failure; Acute Renal Failure with Renal Papillary Necrosis; Address; Adult; Adult Respiratory Distress Syndrome; Albumins; American; Area; Blood Component Removal; Caregivers; Caring; Child; Child Care; Child Support; Childhood; Childhood Injury; Clinical; Collaborations; Communities; Complex; Consensus; Critical Care; Critical Illness; Critically ill children; Data; Devices; Dialysis procedure; Drug Kinetics; Education; Educational workshop; Ethics; Evidence based practice; Extracorporeal Membrane Oxygenation; Face; Failure; Family; Fostering; Future; Goals; Guidelines; Heart-Lung Transplantation; Home; Hospitals; Hybrids; Individual; Institution; International; Knowledge; Learning; Life; Liver; Maps; Medical Care Team; Medical Device; Medicine; Modality; Multiple Organ Failure; National Institute of Child Health and Human Development; Organ; Organ failure; Outcome; Patient Care; Patients; Pediatric Intensive Care Units; Persons; Physiological; Plasmapheresis; Publications; Quality of Care; Recovery; Renal Replacement Therapy; Research; Resources; Resuscitation; Role; Series; Shapes; Societies; Standardization; Structure; Technology; Terminology; Time; Transplantation; Variant; Work; advanced system; base; body system; clinical care; expectation; experience; improved; improved outcome; innovation; medical specialties; meetings; multimodality; novel; pediatric patients; prospective; symposium; ventricular assist device; virtual; working group

Project Summary Pediatric paracorporeal and extracorporeal therapies (PPET) are increasingly applied to support children with multiple organ failure (MOF). These highly complex, resource intensive technologies lie at the interface of innovation and the highest complexity clinical care; in patients with MOF, multiple treatment modalities are frequently used simultaneously. However, lack of clinical guidelines or consensus statements to guide PPET use result in a lack of standardization of practice, compounded by limited dialogue between experts and institutions regarding PPET use, in particular in the application of multiple PPET modalities. Children are further disenfranchised due to the lack of medical devices optimized for the varied size and physiological differences in pediatric practice. There is a critical need for collaborative initiatives aimed at standardization of practice, quality improvement, research and innovation as they relate to the applications of PPET. The PPET Summit 2021 will transform these critical gaps into knowledge and research opportunities by bringing together, for the first time, pediatric and adult experts from across the globe in the fields of extracorporeal membrane oxygenation, ventricular assist device, renal replacement therapy, extracorporeal liver support, and apheresis. The Summit will bring together local and international experts to define the current status of PPET, including the role of hybrid and tandem therapies; standardize current approaches; identify key knowledge gaps that need to be addressed to facilitate optimal patient care, and set a collaborative research and quality agenda to improve our understanding of PPET. This will provide an exciting and much needed framework to optimize the care of these patients and improve their outcomes. Preconference working groups, led by experts selected by the diverse organizing committee around the core domains ((1) patient and family experiences and outcomes; (2) pharmacokinetics; (3) standardization of terminology and quality metrics; (4) innovation; (5) ethics; (6) circuit and organ interactions and cross-talk) will work in a series of highly structured virtual workshops to maximize global participation in the months prior to the Summit to generate consensus statements. The Summit itself will include state of-the-art presentations from the experts to define the current status, underlining the importance of cross-pollination of multiple therapies and approaches. On the final day, a session entitled `Map the Future' will bring together summaries from the pre-conference workshops with all attendees to refine research imperatives for PPET initiatives, including discussion of potential future summits. The proceedings of the first PPET Summit will be disseminated as a series of leading articles in Critical Care and Resuscitation.

项目摘要 儿科旁膝关节和体外治疗（PPET）越来越多地用于支持 多器官功能衰竭（MOF）。这些高度复杂的资源密集型技术 存在于创新和最高复杂性临床护理的界面;在MOF患者中， 经常同时使用多种治疗方式。然而，缺乏临床 指导PPET使用的指南或共识声明导致缺乏标准化， 由于专家和机构之间关于PPET使用的对话有限， 特别是在多个PPET模态的应用中。儿童被进一步剥夺了公民权 由于缺乏针对不同尺寸和生理差异而优化的医疗装置， 儿科实践。迫切需要采取协作举措， 实践，质量改进，研究和创新，因为它们涉及到PPET的应用。 2021年PPET峰会将把这些关键差距转化为知识和研究 第一次将来自世界各地的儿科和成人专家聚集在一起， 地球仪在体外膜氧合、心室辅助装置、肾 替代疗法、体外肝脏支持和单采术。首脑会议将汇集各国 当地和国际专家确定PPET的现状，包括混合动力的作用 和串联疗法;标准化当前的方法;确定需要 旨在促进最佳的患者护理，并制定协作研究和质量 这是为了提高我们对PPET的认识。这将提供一个令人兴奋的和急需的 该框架旨在优化这些患者的护理并改善其结果。 会前工作组，由各组织委员会挑选的专家领导 围绕核心领域（（1）患者和家庭经历和结局;（2）药代动力学; (3)术语和质量指标标准化;（4）创新;（5）道德规范;（6）电路和 器官互动和相声）将在一系列高度结构化的虚拟研讨会， 在首脑会议之前的几个月里，最大限度地扩大全球参与，以达成共识 报表峰会本身将包括专家的最新介绍， 目前的状况，强调多种疗法相互影响的重要性， 接近。在最后一天，题为"描绘未来"的会议将总结 从会前研讨会与所有与会者，以完善研究的必要性PPET 倡议，包括讨论今后可能举行的首脑会议。第一届PPET会议的议事录 峰会将作为一系列重要文章在重症监护和复苏中传播。

项目成果

Cefepime Dosing in a Critically Ill Neonate Receiving Continuous Renal Replacement Therapy With the Cardio-Renal Pediatric Dialysis Emergency Machine (CARPEDIEM).

使用心肾小儿透析急救机 (CARPEDIEM) 接受连续肾脏替代治疗的危重新生儿的头孢吡肟剂量。

• DOI: 10.5863/1551-6776-28.2.167
• 发表时间: 2023
• 期刊: The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
• 作者: Toy,Cynthia;Stimes,Grant;Moore,Megan;Srivaths,Poyyapakkam;Arikan,AyseAkcan
• 通讯作者: Arikan,AyseAkcan

Clearance and nutrition in neonatal continuous kidney replacement therapy using the Carpediem™ system.

使用 Carpediem™ 系统进行新生儿连续肾脏替代治疗的清除和营养。

• DOI: 10.1007/s00467-023-06237-w
• 发表时间: 2024
• 期刊: Pediatric nephrology (Berlin, Germany)
• 作者: Vuong,KimT;Vega,MollyR;Casey,Lauren;Swartz,SarahJ;Srivaths,Poyyapakkam;Osborne,ScottW;Rhee,ChristopherJ;Arikan,AyseAkcan;Joseph,Catherine
• 通讯作者: Joseph,Catherine