Pediatric Paracorporeal and Extracorporeal Therapies (PPET) Summit 2021

项目摘要 儿科体外和体外治疗(PPET)越来越多地被应用于支持 儿童多器官衰竭(MOF)。这些高度复杂、资源密集型的技术 处于创新和最高复杂性临床护理的交界处；在MOF患者中， 经常同时使用多种治疗方式。然而，缺乏临床应用 指导PPET使用的指南或共识声明导致缺乏标准化 实践，再加上专家和机构之间关于PPET使用的有限对话， 尤其是在多种PPET模式的应用中。儿童被进一步剥夺了选举权 由于缺乏针对不同大小和生理差异而优化的医疗设备 儿科诊所。迫切需要以标准化为目标的合作倡议 实践、质量改进、研究和创新，因为它们与PPET的应用有关。 2021年PPET峰会将把这些关键差距转化为知识和研究 通过首次将来自世界各地的儿科和成人专家聚集在一起，创造机会 全球在体外膜氧合、心脏辅助装置、肾脏 替代疗法，体外肝支持，和分离。这次峰会将把 当地和国际专家确定PPET的现状，包括混合体的作用 和串联疗法；标准化当前的方法；确定需要 旨在促进最佳患者护理，并设置协作研究和质量 议程，以提高我们对PPET的理解。这将提供一个令人兴奋和迫切需要的 这一框架旨在优化对这些患者的护理，改善他们的预后。 由多元化组织委员会挑选的专家领导的会前工作组 围绕核心领域(1)患者和家庭的经历和结果；(2)药代动力学； (3)术语和质量指标的标准化；(4)创新；(5)伦理；(6)巡回和 器官互动和相声)将在一系列高度结构化的虚拟研讨会中工作，以 在首脑会议前几个月最大限度地促进全球参与，以达成共识 发言。峰会本身将包括来自专家的最先进的演讲，以确定 目前的状况，强调了多种疗法和方法交叉授粉的重要性 接近了。在最后一天，题为《规划未来》的会议将汇总总结 从与所有与会者的会前研讨会中提炼PPET的研究需求 倡议，包括讨论未来可能举行的首脑会议。第一届PPET会议纪要 峰会将作为危重护理和复苏方面的一系列主要文章进行传播。

Project Summary Pediatric paracorporeal and extracorporeal therapies (PPET) are increasingly applied to support children with multiple organ failure (MOF). These highly complex, resource intensive technologies lie at the interface of innovation and the highest complexity clinical care; in patients with MOF, multiple treatment modalities are frequently used simultaneously. However, lack of clinical guidelines or consensus statements to guide PPET use result in a lack of standardization of practice, compounded by limited dialogue between experts and institutions regarding PPET use, in particular in the application of multiple PPET modalities. Children are further disenfranchised due to the lack of medical devices optimized for the varied size and physiological differences in pediatric practice. There is a critical need for collaborative initiatives aimed at standardization of practice, quality improvement, research and innovation as they relate to the applications of PPET. The PPET Summit 2021 will transform these critical gaps into knowledge and research opportunities by bringing together, for the first time, pediatric and adult experts from across the globe in the fields of extracorporeal membrane oxygenation, ventricular assist device, renal replacement therapy, extracorporeal liver support, and apheresis. The Summit will bring together local and international experts to define the current status of PPET, including the role of hybrid and tandem therapies; standardize current approaches; identify key knowledge gaps that need to be addressed to facilitate optimal patient care, and set a collaborative research and quality agenda to improve our understanding of PPET. This will provide an exciting and much needed framework to optimize the care of these patients and improve their outcomes. Preconference working groups, led by experts selected by the diverse organizing committee around the core domains ((1) patient and family experiences and outcomes; (2) pharmacokinetics; (3) standardization of terminology and quality metrics; (4) innovation; (5) ethics; (6) circuit and organ interactions and cross-talk) will work in a series of highly structured virtual workshops to maximize global participation in the months prior to the Summit to generate consensus statements. The Summit itself will include state of-the-art presentations from the experts to define the current status, underlining the importance of cross-pollination of multiple therapies and approaches. On the final day, a session entitled `Map the Future' will bring together summaries from the pre-conference workshops with all attendees to refine research imperatives for PPET initiatives, including discussion of potential future summits. The proceedings of the first PPET Summit will be disseminated as a series of leading articles in Critical Care and Resuscitation.