Administrative Core

行政核心

• 批准号: 10158452
• 负责人: Erica Ollmann Saphire
• 金额: $ 31.99万
• 依托单位: LA JOLLA INSTITUTE FOR IMMUNOLOGY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10158452
• 关键词: Alphavirus; Animal Model; Antibodies; Arenavirus; Biochemical; Biological Assay; Cell Line; Cells; Clinical; Clinical Trials; Collaborations; Communication; Communities; Data; Data Analyses; Data Set; Databases; Deposition; Development; Discipline; Emergency Situation; Ensure; Filovirus; Fostering; Future; Goals; Guidelines; Head; Human; Immunotherapeutic agent; Individual; Institution; Intellectual Property; Laboratories; Location; Machine Learning; Methodology; Monitor; Occupational activity of managing finances; Phase; Plants; Preclinical Testing; Preparation; Process; Progress Reports; Publications; Reagent; Research; Research Activity; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Scientist; Series; Techniques; Teleconferences; Testing; Time; Toxicology; Translational Research; Translations; United States National Institutes of Health; Vertebrates; Viral; Viral Antibodies; World Health Organization; base; clinical application; cohesion; collaborative environment; data repository; design; experimental study; frontier; human subject; interest; meetings; multidisciplinary; outreach; phase 1 study; preclinical study; product development; programs; research study; scientific organization; success; therapeutically effective; web site

Project Summary This Administrative Core will provide the necessary scientific, organization, and fiscal oversight for the Consortium for Immunotherapeutics Against Emerging Viral Threats. This Consortium includes multiple investigators who will conduct studies involving a large array of antibodies, cell lines, biochemical and cell-based assays, animal models and machine learning techniques that will be critical for developing effective therapeutics for alphaviruses, arenaviruses, and filoviruses. An essential feature of the consortium is the coordination of projects and studies on these antibodies and resources to minimize duplication of efforts and maximize integration of the separate multidisciplinary analyses. The Administrative Core will develop and implement a management plan to ensure the success of this program. The Core will continuously monitor the scientific progress of each program component, as well as ensure that results are collated and interpreted, and that subsequent action steps are effectively communicated to the entire group at each stage of the study. The Core will also facilitate communications with the Center, NIH, and the larger research community, as well as our external advisors to promote effective translation of results toward the development of products and clinical applications. The Core will manage financial resources and ensure that select agent, vertebrate animal, human subject, and intellectual property issues are respected, that data are deposited, and resources shared with the scientific community. The Core will also initiate all external collaboration and oversee invitation, selection, and progress of Supplemental Research activities as directed by the NIH. Furthermore, the Core includes a Clinical Consultant who will advise on the translation of research findings to small clinical trials.

项目总结