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Administrative Core

Administrative Core
行政核心
批准号:
10158452
负责人:
Erica Ollmann Saphire
金额:
$31.99万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-05-01 至 2024-04-30

项目摘要

项目成果

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中文摘要
翻译
项目摘要 这个行政核心将提供必要的科学、组织和财政监督 针对新出现的病毒威胁的免疫疗法联盟。该联盟包括多个 研究人员将进行涉及大量抗体、细胞系、生化和基于细胞的研究 测试、动物模型和机器学习技术将是开发有效疗法的关键 用于甲型病毒、天鹅型病毒和丝状病毒。财团的一个基本特征是协调 关于这些抗体和资源的项目和研究,以最大限度地减少重复工作和最大限度地 整合独立的多学科分析。 行政核心将制定和实施一项管理计划,以确保该计划的成功。 核心将持续监测每个方案组成部分的科学进展,并确保 对结果进行整理和解释,并有效地将后续行动步骤传达给 在研究的每个阶段分组。该核心还将促进与该中心、美国国立卫生研究院和 更大的研究社区,以及我们的外部顾问,以促进有效地将结果转化为 产品开发和临床应用。核心将管理财政资源,并确保 选择代理人、脊椎动物、人类主体和知识产权问题得到尊重,数据得到尊重 存放,并与科学界共享资源。核心还将启动所有外部 根据指导,协作并监督补充研究活动的邀请、选择和进度 美国国立卫生研究院。此外,核心包括一名临床顾问,他将就研究的翻译提供建议 小规模临床试验的结果。
英文摘要
Project Summary This Administrative Core will provide the necessary scientific, organization, and fiscal oversight for the Consortium for Immunotherapeutics Against Emerging Viral Threats. This Consortium includes multiple investigators who will conduct studies involving a large array of antibodies, cell lines, biochemical and cell-based assays, animal models and machine learning techniques that will be critical for developing effective therapeutics for alphaviruses, arenaviruses, and filoviruses. An essential feature of the consortium is the coordination of projects and studies on these antibodies and resources to minimize duplication of efforts and maximize integration of the separate multidisciplinary analyses. The Administrative Core will develop and implement a management plan to ensure the success of this program. The Core will continuously monitor the scientific progress of each program component, as well as ensure that results are collated and interpreted, and that subsequent action steps are effectively communicated to the entire group at each stage of the study. The Core will also facilitate communications with the Center, NIH, and the larger research community, as well as our external advisors to promote effective translation of results toward the development of products and clinical applications. The Core will manage financial resources and ensure that select agent, vertebrate animal, human subject, and intellectual property issues are respected, that data are deposited, and resources shared with the scientific community. The Core will also initiate all external collaboration and oversee invitation, selection, and progress of Supplemental Research activities as directed by the NIH. Furthermore, the Core includes a Clinical Consultant who will advise on the translation of research findings to small clinical trials.
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Structure of the SARS-CoV-2 Nucleocapsid: building block to viral capsid
  • 批准号:
    10728253
  • 项目类别:
  • 资助金额:
    $28.59万
  • 财政年份:
    2023
  • 负责人:
    Erica Ollmann Saphire
  • 依托单位:
Integrative Immunogen Design and Testing
  • 批准号:
    10842890
  • 项目类别:
  • 资助金额:
    $206.09万
  • 财政年份:
    2021
  • 负责人:
    Erica Ollmann Saphire
  • 依托单位:
Consortium for Immunotherapeutics against Emerging Viral Threats
  • 批准号:
    10447562
  • 项目类别:
  • 资助金额:
    $190.37万
  • 财政年份:
    2021
  • 负责人:
    Erica Ollmann Saphire
  • 依托单位:
Integrative Immunogen Design and Testing
  • 批准号:
    10328121
  • 项目类别:
  • 资助金额:
    $262.89万
  • 财政年份:
    2021
  • 负责人:
    Erica Ollmann Saphire
  • 依托单位:
海外基金