Administrative Core

行政核心

• 批准号: 10158452
• 负责人: Erica Ollmann Saphire
• 金额: $ 31.99万
• 依托单位: LA JOLLA INSTITUTE FOR IMMUNOLOGY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10158452
• 关键词: Alphavirus; Animal Model; Antibodies; Arenavirus; Biochemical; Biological Assay; Cell Line; Cells; Clinical; Clinical Trials; Collaborations; Communication; Communities; Data; Data Analyses; Data Set; Databases; Deposition; Development; Discipline; Emergency Situation; Ensure; Filovirus; Fostering; Future; Goals; Guidelines; Head; Human; Immunotherapeutic agent; Individual; Institution; Intellectual Property; Laboratories; Location; Machine Learning; Methodology; Monitor; Occupational activity of managing finances; Phase; Plants; Preclinical Testing; Preparation; Process; Progress Reports; Publications; Reagent; Research; Research Activity; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Scientist; Series; Techniques; Teleconferences; Testing; Time; Toxicology; Translational Research; Translations; United States National Institutes of Health; Vertebrates; Viral; Viral Antibodies; World Health Organization; base; clinical application; cohesion; collaborative environment; data repository; design; experimental study; frontier; human subject; interest; meetings; multidisciplinary; outreach; phase 1 study; preclinical study; product development; programs; research study; scientific organization; success; therapeutically effective; web site

Project Summary This Administrative Core will provide the necessary scientific, organization, and fiscal oversight for the Consortium for Immunotherapeutics Against Emerging Viral Threats. This Consortium includes multiple investigators who will conduct studies involving a large array of antibodies, cell lines, biochemical and cell-based assays, animal models and machine learning techniques that will be critical for developing effective therapeutics for alphaviruses, arenaviruses, and filoviruses. An essential feature of the consortium is the coordination of projects and studies on these antibodies and resources to minimize duplication of efforts and maximize integration of the separate multidisciplinary analyses. The Administrative Core will develop and implement a management plan to ensure the success of this program. The Core will continuously monitor the scientific progress of each program component, as well as ensure that results are collated and interpreted, and that subsequent action steps are effectively communicated to the entire group at each stage of the study. The Core will also facilitate communications with the Center, NIH, and the larger research community, as well as our external advisors to promote effective translation of results toward the development of products and clinical applications. The Core will manage financial resources and ensure that select agent, vertebrate animal, human subject, and intellectual property issues are respected, that data are deposited, and resources shared with the scientific community. The Core will also initiate all external collaboration and oversee invitation, selection, and progress of Supplemental Research activities as directed by the NIH. Furthermore, the Core includes a Clinical Consultant who will advise on the translation of research findings to small clinical trials.

项目摘要 这一行政核心将提供必要的科学，组织和财政监督， 免疫治疗联盟对抗新出现的病毒威胁。该联盟包括多个 研究人员将进行涉及大量抗体，细胞系，生物化学和基于细胞的研究 分析，动物模型和机器学习技术，这对开发有效的治疗方法至关重要 甲病毒、沙粒病毒和丝状病毒。联合体的一个基本特点是协调 这些抗体和资源的项目和研究，以尽量减少重复努力， 整合单独的多学科分析。 行政核心将制定和实施管理计划，以确保该计划的成功。 核心将持续监测每个计划组成部分的科学进展，并确保 对结果进行整理和解释，并将后续行动步骤有效地传达给整个 在研究的每个阶段。核心还将促进与中心、NIH和 更大的研究社区，以及我们的外部顾问，以促进成果的有效转化， 产品开发和临床应用。核心小组将管理财政资源，并确保 选择代理人，脊椎动物，人类受试者和知识产权问题得到尊重，数据 并与科学界共享资源。核心也会启动所有外部 合作并监督补充研究活动的邀请、选择和进展， 国家卫生研究院此外，核心包括一名临床顾问，他将对研究的翻译提供建议。 小型临床试验的结果。