Consortium for Immunotherapeutics against Emerging Viral Threats
针对新兴病毒威胁的免疫治疗联盟
基本信息
- 批准号:9924443
- 负责人:
- 金额:$ 714.34万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-05-01 至 2024-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAlphavirusAntibodiesAntigen TargetingArenavirusArthritogenicBiological AssayCommunicable DiseasesComputer AnalysisComputer ModelsComputing MethodologiesCoupledCulicidaeDataDatabasesDeveloped CountriesDeveloping CountriesDiseaseEbolaEbola virusEpidemicEvolutionFamilyFilovirusFosteringGoalsHandHealthHumanImmuneImmunotherapeutic agentLassa virusMachine LearningMathematicsMediatingMonoclonal AntibodiesMonoclonal Antibody TherapyMovementMultivariate AnalysisNaturePopulations at RiskPrimate DiseasesReagentResearch Project GrantsResourcesStatistical Data InterpretationSystemTalentsTestingTherapeuticTherapeutic Monoclonal AntibodiesTranslatingTranslationsUnited StatesVaccinesViralVirusVirus Diseasesbasebiodefensechikungunyaclinical developmentdesignexperiencehuman monoclonal antibodiesimprovedindustry partnerinnovationinsightmosquito-bornemultidisciplinarynonhuman primatenovelpandemic diseasepathogenprogramsresearch studystructural biologysuccesssynergismtool
项目摘要
SUMMARY: OVERALL
This proposal, Consortium for Immunotherapeutics Against Emerging Viral Diseases, addresses a critical
gap in the biodefense portfolio by building an academic-industry partnership to advance effective, fully human,
antibody-based immunotherapeutics against three major families of emerging/re-emerging viruses: Lassa virus,
Ebola and other Filoviruses, and mosquito-transmitted Alphaviruses that threaten millions worldwide. This
program follows directly from our significant body of preliminary data (the largest available for these families of
viruses), therapeutics in hand, multidisciplinary expertise, and demonstrated collaborative success. Included in
the proposed CETR portfolio are: (1) the only available immunotherapeutics against endemic Lassa virus, with
reversal of late-stage disease and complete survival in infected non-human primates, (2) novel Ebola and pan-
ebolavirus therapeutics that also completely protect non-human primates from disease, and that were built by
the paradigm-shifting and comprehensive analysis of a global consortium, and (3) much needed, first-in-class
therapeutics against the re-emerging alphaviruses that have tremendous epidemic potential in the United States
and around the globe. These multidisciplinary studies, founded upon pioneering structural biology of the antigen
targets, include innovations such as agnostic, high-throughput Fc profiling and optimization, coupled with Fv
evolution to enhance potency and developability, as well as a sophisticated statistical and computational analysis
core to evaluate thresholds and correlates of protection across the major families of pathogens. Together, we
aim to understand what findings represent general rules and what data are specific to each virus family. We also
aim to provide streamlined systems for antibody choice and optimization that do not yet exist, and to build a
broadly applicable platform for mAb discovery and delivery against any novel pathogen as they emerge. The
recent resurgence of Lassa, the epidemic nature of Ebola virus and other re-emerging filoviruses, as well as the
major population at risk by global movement of mosquito-borne alphaviruses together demonstrate the
tremendous global need for immunotherapeutics developed and advanced by this program.
总结:总体
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Erica Ollmann Saphire其他文献
Virus nomenclature below the species level: a standardized nomenclature for natural variants of viruses assigned to the family Filoviridae
- DOI:
10.1007/s00705-012-1454-0 - 发表时间:
2012-09-23 - 期刊:
- 影响因子:2.500
- 作者:
Jens H. Kuhn;Yiming Bao;Sina Bavari;Stephan Becker;Steven Bradfute;J. Rodney Brister;Alexander A. Bukreyev;Kartik Chandran;Robert A. Davey;Olga Dolnik;John M. Dye;Sven Enterlein;Lisa E. Hensley;Anna N. Honko;Peter B. Jahrling;Karl M. Johnson;Gary Kobinger;Eric M. Leroy;Mark S. Lever;Elke Mühlberger;Sergey V. Netesov;Gene G. Olinger;Gustavo Palacios;Jean L. Patterson;Janusz T. Paweska;Louise Pitt;Sheli R. Radoshitzky;Erica Ollmann Saphire;Sophie J. Smither;Robert Swanepoel;Jonathan S. Towner;Guido van der Groen;Viktor E. Volchkov;Victoria Wahl-Jensen;Travis K. Warren;Manfred Weidmann;Stuart T. Nichol - 通讯作者:
Stuart T. Nichol
The C-terminus of Sudan ebolavirus VP40 contains a functionally important CXsubn/subC motif, a target for redox modifications
苏丹埃博拉病毒 VP40 的 C 末端包含一个功能重要的 CXC 基序,这是氧化还原修饰的一个靶点。
- DOI:
10.1016/j.str.2023.06.004 - 发表时间:
2023-09-07 - 期刊:
- 影响因子:4.300
- 作者:
Anke-Dorothee Werner;Martin Schauflinger;Michael J. Norris;Michael Klüver;Anna Trodler;Astrid Herwig;Christina Brandstädter;Melissa Dillenberger;Gerhard Klebe;Andreas Heine;Erica Ollmann Saphire;Katja Becker;Stephan Becker - 通讯作者:
Stephan Becker
Infusion of neutralization into Lassa vaccine design
将中和作用注入拉沙疫苗设计中
- DOI:
10.1016/j.it.2025.05.006 - 发表时间:
2025-07-01 - 期刊:
- 影响因子:13.900
- 作者:
Haoyang Li;Kathryn M. Hastie;Erica Ollmann Saphire - 通讯作者:
Erica Ollmann Saphire
A global collaboration for systematic analysis of broad-ranging antibodies against the SARS-CoV-2 spike protein
针对 SARS-CoV-2 刺突蛋白的广泛抗体的系统分析的全球合作
- DOI:
10.1016/j.celrep.2025.115499 - 发表时间:
2025-04-22 - 期刊:
- 影响因子:6.900
- 作者:
Sharon L. Schendel;Xiaoying Yu;Peter J. Halfmann;Jarjapu Mahita;Brendan Ha;Kathryn M. Hastie;Haoyang Li;Daniel Bedinger;Camille Troup;Kan Li;Natalia Kuzmina;Jordi B. Torrelles;Jennifer E. Munt;Melissa Mattocks;Mary Osei-Twum;Heather M. Callaway;The CoVIC-DB Team;Stephen Reece;Anne Palser;Paul Kellam;S. Moses Dennison;Erica Ollmann Saphire - 通讯作者:
Erica Ollmann Saphire
Recurring conformation of the human immunodeficiency virus type 1 gp120 V3 loop.
人类免疫缺陷病毒 1 型 gp120 V3 环的重复构象。
- DOI:
10.1016/s0042-6822(03)00525-7 - 发表时间:
2003 - 期刊:
- 影响因子:3.7
- 作者:
R. Stanfield;J. Ghiara;Erica Ollmann Saphire;A. Profy;I. Wilson - 通讯作者:
I. Wilson
Erica Ollmann Saphire的其他文献
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{{ truncateString('Erica Ollmann Saphire', 18)}}的其他基金
Structure of the SARS-CoV-2 Nucleocapsid: building block to viral capsid
SARS-CoV-2 核衣壳的结构:病毒衣壳的构建模块
- 批准号:
10728253 - 财政年份:2023
- 资助金额:
$ 714.34万 - 项目类别:
Consortium for Immunotherapeutics against Emerging Viral Threats
针对新兴病毒威胁的免疫治疗联盟
- 批准号:
10447562 - 财政年份:2021
- 资助金额:
$ 714.34万 - 项目类别:
Consortium for Immunotherapeutics against Emerging Viral Threats
针对新兴病毒威胁的免疫治疗联盟
- 批准号:
10199909 - 财政年份:2020
- 资助金额:
$ 714.34万 - 项目类别:
Specific and Broadly Active Monoclonal Antibody Therapeutics Against The Filoviruses
针对丝状病毒的特异性且广泛活性的单克隆抗体疗法
- 批准号:
10402338 - 财政年份:2019
- 资助金额:
$ 714.34万 - 项目类别:
Specific and Broadly Active Monoclonal Antibody Therapeutics Against The Filoviruses
针对丝状病毒的特异性且广泛活性的单克隆抗体疗法
- 批准号:
10158448 - 财政年份:2019
- 资助金额:
$ 714.34万 - 项目类别:
Specific and Broadly Active Monoclonal Antibody Therapeutics Against The Filoviruses
针对丝状病毒的特异性且广泛活性的单克隆抗体疗法
- 批准号:
10617736 - 财政年份:2019
- 资助金额:
$ 714.34万 - 项目类别:
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