An investigation of a parent/child psycho-social computerized intervention targeting the error-related negativity in young children

针对幼儿错误相关消极情绪的父母/儿童心理社会计算机化干预的调查

• 批准号: 10158510
• 负责人: Alexandria M Meyer
• 金额: $ 9万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10158510
• 关键词: 4 year old; 6 year old; Adolescent; Age; Anxiety; Anxiety Disorders; Biological Markers; Brain; Child; Child Rearing; Childhood; Combined Modality Therapy; Control Groups; Data; Development; Environmental Risk Factor; Event-Related Potentials; Exposure to; Impairment; Individual; Intervention; Investigation; K-Series Research Career Programs; Life; Longevity; Measures; Mediating; Mentors; Only Child; Outcome; Parents; Patient Self-Report; Pattern; Psychopathology; Punishment; Randomized; Reporting; Risk; Risk Factors; Risk Marker; Sampling; Shapes; Statistical Data Interpretation; Symptoms; Testing; Training; Visit; Work; anxiety symptoms; anxious; anxious individuals; base; clinical anxiety; computerized; design; experience; follow up assessment; follow-up; novel; offspring; post intervention; prevent; prospective; psychosocial; recruit; relating to nervous system; response; therapy design; treatment group

Abstract Anxiety disorders are the most common form of psychopathology, frequently begin in childhood, and are often associated with substantial lifelong impairment. Thus, there is a critical need and opportunity to identify neural markers of risk that distinguish anxious from healthy trajectories early in development that may serve as novel targets for intervention – especially if they are evident before symptoms have become impairing. One promising neural marker of anxiety is increased brain activity in response to mistakes, as reflected by the error-related negativity (ERN). Considering that the ERN is elevated before anxiety symptoms become impairing, it is critical to identify environmental factors that may shape the ERN early in life – so that those factors can be manipulated to reduce the ERN and potentially mitigate risk. In a sample of 295 six-year old children, we found that both observational and self-report measures of harsh parenting style related to an increased ERN in offspring. A similar pattern of results was reported by another lab amongst 4 year-old children. Moreover, results suggested that the ERN mediated the relationship between harsh parenting and child anxiety disorders. Based on these data, we propose to develop a novel psychosocial intervention to be administered to both parents and children, which aims to normalize the ERN in children (i.e., reduce over-reactivity to making errors). The proposed Mentored Career Development Award (K01) is designed to extend my previous work on the ERN, parenting, and risk for anxiety in young children to test the extent to which the ERN can be modulated. Specifically, we will recruit 175 parent/child dyads, high in error sensitivity, and randomize 25 to a control condition, 50 to a parent only condition, 50 to a child only condition, and 50 to a parent/child condition. We will measure the ERN in children pre and post intervention, as well as baseline anxiety symptoms. At a six-month follow-up, we will assess children’s ERN, as well as anxiety symptoms. Moreover, my training plan builds on my expertise on the ERN and anxiety, and integrates expertise in the design and implementation of computerized interventions, as well as advanced statistical analyses related to intervention outcomes.

摘要 焦虑症是最常见的精神病理学形式，通常开始于童年， 往往伴随着终生的严重损伤。因此，迫切需要并有机会 识别神经风险标志物，区分焦虑和发展早期的健康轨迹， 作为新的干预目标-特别是如果它们在症状出现之前就很明显， 损害。焦虑的一个有希望的神经标记是对错误的反应增加的大脑活动， 错误相关负性（ERN）。考虑到ERN在焦虑前升高 当症状变得损害时，识别可能在生命早期形成ERN的环境因素至关重要 - 这样就可以操纵这些因素来降低ERN并潜在地降低风险。在295个样本中， 六岁的孩子，我们发现，无论是观察和自我报告的措施，严厉的养育方式， 与后代ERN增加有关。4个实验室中的另一个实验室报告了类似的结果模式 岁的孩子。此外，结果表明，ERN介导了苛刻之间的关系， 育儿和儿童焦虑症。 基于这些数据，我们建议开发一种新的心理社会干预， 父母和孩子，其目的是使儿童的ERN正常化（即，减少反应过度， 错误）。建议的指导职业发展奖（K 01）旨在扩展我以前的工作， ERN、父母养育和幼儿焦虑的风险，以测试ERN可以在多大程度上 调制的具体来说，我们将招募175对错误敏感度高的父母/孩子对，并将25对随机分配给一对 控制条件，50到仅父条件，50到仅子条件，以及50到父/子条件。 我们将测量干预前后儿童的ERN，以及基线焦虑症状。在 六个月的随访，我们将评估儿童的ERN，以及焦虑症状。而且我的训练计划 基于我在ERN和焦虑方面的专业知识，并将专业知识整合到设计和实施中， 计算机化干预措施以及与干预结果有关的先进统计分析。