An investigation of a parent/child psycho-social computerized intervention targeting the error-related negativity in young children

针对幼儿错误相关消极情绪的父母/儿童心理社会计算机化干预的调查

• 批准号: 10597609
• 负责人: Alexandria M Meyer
• 金额: $ 0.15万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2023-09-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10597609
• 关键词: 4 year old; 6 year old; Adolescent; Age; Anxiety; Anxiety Disorders; Biological Markers; Brain; Child; Child Rearing; Childhood; Combined Modality Therapy; Control Groups; Data; Development; Dissociation; Environmental Risk Factor; Event-Related Potentials; Exposure to; Impairment; Individual; Intervention; Investigation; K-Series Research Career Programs; Life; Longevity; Measures; Mediating; Mentors; Only Child; Outcome; Parents; Patient Self-Report; Pattern; Psychopathology; Punishment; Randomized; Reporting; Risk; Risk Factors; Risk Marker; Sampling; Shapes; Statistical Data Interpretation; Symptoms; Testing; Training; Visit; Work; anxiety symptoms; anxious; anxious individuals; biomarker identification; clinical anxiety; comparison control; computerized; design; experience; follow up assessment; follow-up; neural; novel; offspring; post intervention; prevent; prospective; psychosocial; recruit; response; risk mitigation; risk prediction; therapy design; treatment group

Abstract Anxiety disorders are the most common form of psychopathology, frequently begin in childhood, and are often associated with substantial lifelong impairment. Thus, there is a critical need and opportunity to identify neural markers of risk that distinguish anxious from healthy trajectories early in development that may serve as novel targets for intervention – especially if they are evident before symptoms have become impairing. One promising neural marker of anxiety is increased brain activity in response to mistakes, as reflected by the error-related negativity (ERN). Considering that the ERN is elevated before anxiety symptoms become impairing, it is critical to identify environmental factors that may shape the ERN early in life – so that those factors can be manipulated to reduce the ERN and potentially mitigate risk. In a sample of 295 six-year old children, we found that both observational and self-report measures of harsh parenting style related to an increased ERN in offspring. A similar pattern of results was reported by another lab amongst 4 year-old children. Moreover, results suggested that the ERN mediated the relationship between harsh parenting and child anxiety disorders. Based on these data, we propose to develop a novel psychosocial intervention to be administered to both parents and children, which aims to normalize the ERN in children (i.e., reduce over-reactivity to making errors). The proposed Mentored Career Development Award (K01) is designed to extend my previous work on the ERN, parenting, and risk for anxiety in young children to test the extent to which the ERN can be modulated. Specifically, we will recruit 175 parent/child dyads, high in error sensitivity, and randomize 25 to a control condition, 50 to a parent only condition, 50 to a child only condition, and 50 to a parent/child condition. We will measure the ERN in children pre and post intervention, as well as baseline anxiety symptoms. At a six-month follow-up, we will assess children’s ERN, as well as anxiety symptoms. Moreover, my training plan builds on my expertise on the ERN and anxiety, and integrates expertise in the design and implementation of computerized interventions, as well as advanced statistical analyses related to intervention outcomes.

摘要 焦虑症是最常见的精神病理形式，通常始于儿童时期， 往往与严重的终生损害有关。因此，存在着迫切的需要和机会 识别神经风险标记物，区分焦虑和健康的早期发展轨迹，可能 作为新的干预目标-特别是在症状出现之前就已经明显的情况下 正在损害中。焦虑的一个有希望的神经标志是对错误反应的大脑活动增加，如 反映在错误相关负波(ERN)上。考虑到ERN在焦虑之前就升高了 症状变得损害，关键是找出可能在生命早期塑造ERN的环境因素 -以便可以操纵这些因素来降低ERN并潜在地降低风险。在295个样本中 对六岁儿童，我们发现观察性和自我报告性的父母教养方式都比较严厉 与子代ERN增加有关。另一个实验室报告了类似的结果，其中4个 一岁大的孩子。此外，结果表明ERN在刺激性刺激之间的关系中起中介作用。 育儿和儿童焦虑症。 基于这些数据，我们建议开发一种新的心理社会干预措施，用于 父母和儿童，旨在使儿童的ERN正常化(即减少对 错误)。拟议的导师职业发展奖(K01)旨在扩展我之前的工作 幼儿的ERN、父母教养方式和焦虑风险，以测试ERN的程度 调制过的。具体地说，我们将招募175名错误敏感度高的父母/孩子二元组，并随机选择25名 控制条件，50表示仅父项条件，50表示仅限子条件，50表示父项/子项条件。 我们将测量干预前后儿童的ERN，以及基线焦虑症状。在一次 随访6个月，评估儿童ERN情况，以及焦虑症状。而且，我的训练计划 以我在ERN和焦虑方面的专业知识为基础，并将专业知识整合到设计和实施 计算机化干预，以及与干预结果相关的高级统计分析。