Tissue Engineering Resource Center-Treatment of COVID-19 induced acute respiratory distress by inhalation of exosomes

组织工程资源中心-吸入外泌体治疗COVID-19引起的急性呼吸窘迫

• 批准号: 10164179
• 负责人: Gordana Vunjak-Novakovic
• 金额: $ 46.7万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-27 至 2021-07-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10164179
• 关键词: Academic Medical Centers; Adult Respiratory Distress Syndrome; Advisory Committees; Area; Automation; Awareness; Basic Science; Biocompatible Materials; Biological; Biomedical Engineering; Bioreactors; COVID-19; Cells; Clinic; Clinical; Collaborations; Communities; Complex; Development; Disease; Disease model; Education and Outreach; Engineering; Ensure; Environment; Event; Feedback; Financial Support; Fostering; Foundations; General Population; Goals; Heart; High School Student; Hospitals; Human; Human Engineering; Image; In Vitro; Inhalation; Institution; Lead; Leadership; Letters; Link; Measurement; Measures; Mission; Modality; Myocardial Infarction; Natural regeneration; Optics; Organ; Outcome; Perfusion; Physiological Processes; Presbyterian Church; Recording of previous events; Regenerative Medicine; Research; Research Ethics; Research Personnel; Resources; Role; Schools; Services; Signal Transduction; Strategic Planning; Structure; Students; System; Technology; Therapeutic; Time; Tissue Engineering; Tissues; Training; Translating; Translational Research; Translations; Universities; Vision; Visualization; base; cellular imaging; clinical practice; clinical translation; design; driving force; exosome; experience; functional restoration; human tissue; improved; in vivo; innovation; lung regeneration; new technology; next generation; operation; outreach; outreach program; program dissemination; public health relevance; regenerative; response; restoration; scaffold; screening; spatiotemporal; technology development; technology research and development; tissue culture; treatment center

SUMMARY Tissue engineering is rapidly developing, but remains limited by (i) scaffold and bioreactor designs that are based on predetermined parameters, and (ii) the lack of real-time, nondestructive measurements of cell and tissue function. To overcome these two limitations, we will develop adaptive-responsive biomaterials that can sense environmental signals and actuate the cells, and imaging-enabled bioreactors with real-time spatiotemporal control of engineered tissues with feedback from the measured cell responses. Our goal is to offer these advances to the tissue engineering community, and translate them into clinic. The proposed Tissue Engineering Resource Center brings together four highly productive and actively collaborating investigators from Columbia University (lead institution), Tufts University and Columbia University Medical Center-Presbyterian Hospital. An Administrative Board will coordinate the Center's activities, in conjunction with an External Advisory Committee, formed from the world leaders in tissue engineering and clinical translation that will evaluate the Center and provide guidance in strategic planning. The Center will partner with a number of existing resources (please see 13 letters of collaboration), and will have very generous financial support of the Columbia University School of Engineering ($2,425,000 over the five-year cycle). Strong and effective leadership is uniquely suited to support this transformative Center. The technical components of the Center are three Technology Research and Development Projects (TRD1: Adaptive-responsive biomaterials; TRD2: Imaging enabled bioreactor systems; TRD3: Regenerative engineering), eight Collaborative Projects and six Service Projects. We also propose a robust and diverse Training and Dissemination program to provide links between the projects in the Center with training of biomedical investigators in the use of new technologies, and the outreach to students, general public and underserved communities. Our mission is is that the Center will serve as a transformative driving force for the field of tissue engineering, by developing and translating new technologies, providing training and service, and offering dissemination and outreach programs for general public and high school students. With a highly innovative scientific premise, extensive foundational research, strong leadership and institutional support, experience in translational research, and long history of collaboration among the lead investigators, we are confident that the Center will accomplish its mission.

总结 组织工程正在迅速发展，但仍然受到以下因素的限制：（i）支架和生物反应器设计， 基于预定参数，以及（ii）缺乏对细胞的实时、非破坏性测量 和组织功能。为了克服这两个限制，我们将开发自适应响应生物材料 可以感知环境信号并激活细胞，以及实时成像的生物反应器， 利用来自测量的细胞反应的反馈对工程化组织进行时空控制。我们的目标是 将这些进展提供给组织工程界，并将其转化为临床。拟议 组织工程资源中心汇集了四个高效和积极合作的 来自哥伦比亚大学（牵头机构）、塔夫茨大学和哥伦比亚大学医学院的研究者 中心长老会医院一个管理委员会将协调中心的活动， 与外部咨询委员会，由世界领先的组织工程和临床 翻译，将评估该中心，并提供指导，在战略规划。该中心将与 与现有的资源（请参阅13合作信），并将有非常慷慨的 哥伦比亚大学工程学院的财政支助（五年周期2 425 000美元）。 强有力和有效的领导是唯一适合支持这一变革中心。 该中心的技术组成部分是三个技术研究和开发项目 (TRD1：适应性响应生物材料; TRD 2：成像生物反应器系统; TRD 3： 再生工程），八个合作项目和六个服务项目。我们还提出了一个 强大而多样化的培训和传播计划，以提供项目之间的联系， 该中心培训生物医学研究人员使用新技术，并推广到 学生、公众和服务不足的社区。我们的使命是，该中心将作为一个 组织工程领域的变革驱动力，通过开发和翻译新的 技术，提供培训和服务，并为公众提供传播和推广方案， 公立学校和高中学生。具有高度创新性的科学前提，广泛的基础性 研究，强大的领导和机构支持，在转化研究的经验，和悠久的历史， 通过主要调查人员之间的合作，我们相信该中心将完成其使命。