Advancing the Use of Oral Fluid to Monitor Therapeutic and Illicit Drugs in Outpatient Clinical and Field Settings
Advancing the Use of Oral Fluid to Monitor Therapeutic and Illicit Drugs in Outpatient Clinical and Field Settings
批准号:
10161959
负责人:
Stephen Magura
金额:
$12.88万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-09-30 至 2022-08-31
关键词:
Admission activityAmphetaminesBiologyBladderClientClinicalClinical ResearchCocaineCollectionConeDataDesigner DrugsDetectionDrug CompoundingDrug CourtsDrug MonitoringDrug ScreeningDrug usageDrug userEarly DiagnosisEmployeeEpidemicEpidemiologyEthanolEthnic OriginFentanylGenderHourHouseholdIllicit DrugsImmunoassayIndividualIngestionLeadLiquid ChromatographyLiquid substanceLow PrevalenceMarijuanaMeasurementMethadoneMethamphetamineMonitorOralOutcomeOutpatientsOxycodoneParentsPatient Self-ReportPatientsPharmaceutical PreparationsPrivacyPublic HealthRaceResearchResearch PersonnelSafetySample SizeSamplingSampling StudiesSpecimenSubstance Abuse DetectionSurveysTechniquesTechnologyTestingTherapeuticTimeUnited States Substance Abuse and Mental Health Services AdministrationUrinalysisUrineWorkplaceaddictionchild protective servicechronic pain patientdrug misusedrug of abusedrug testingepidemiology studyimprovedliquid chromatography mass spectrometrymethadone patientmethadone treatmentopioid epidemicparoleprobationprogramsrecruitresearch studysample collectionscreeningsynthetic opioidtandem mass spectrometryvirtual
中文摘要
口服液检测药物滥用的技术一直在进步,但尿液分析仍然是最落后的
英文摘要
The technology of oral fluid testing for drugs of abuse has been advancing, but urinalysis remains the
standard matrix for drug screening in most settings, including methadone maintenance and other outpatient
addiction treatment, despite major practical advantages of oral fluid over urine specimen collection. These are
specifically the elimination of privacy issues (and increase in patient dignity), the need for a dedicated bathroom,
the need for a same-gender observer (if observation is done), no effects of “shy bladder”, and the near elimination
of potential adulteration of specimens, the latter requiring numerous validity tests to detect for urine. Recent
research indicates that with the use of state of art techniques (liquid chromatography with tandem mass
spectrometry- LC/MS/MS), the overall window of detection has become similar for oral fluid and urine. Despite
these advantages, oral fluid is still not widely used in methadone treatment, other outpatient addiction treatment,
and other settings such as probation/parole programs, drug courts, safety-sensitive workplaces, and child
protective services, that need to monitor the drug use of their clients or employees. In addition, there is great
potential for using oral fluid in drug epidemiological studies, such as household surveys and “street studies,”
where urinalysis is largely impractical, but where timely drug surveillance is critical for early detection of and
changes in local and national drug epidemics. In particular, expansion of oral fluid drug testing would contribute
to “real time surveillance of the opioid crisis” (President’s Commission, 2017), including better monitoring of the
abuse of powerful synthetic opioids (e.g., fentanyl, oxycodone).
One important barrier to the wider use of oral fluid is a paucity of contemporary data comparing the results of
oral fluid analysis to urinalysis, the current standard, for large samples of paired specimens provided by the same
individuals at the same time. Consequently, the specific aims of this application are:
1. Identify differences (if any) between oral fluid analysis and urinalysis in the detection of different major drug
classes and the most common drug compounds within a set of 123 possible compounds, including recent
“designer drugs.” The study will compare the results between state-of-the-art oral fluid testing and urinalysis for
new patients admitted to methadone maintenance treatment nationally (n = 1,000), selected for regional diversity.
2. Determine the utility of oral fluid and urine drug screening by LC/MS/MS-only as compared with standard
immunoassay screening followed by LC/MS/MS confirmation of positives only.
3. Determine the sensitivity of oral fluid analysis and urinalysis as compared with self-reports of recent drug
use obtained at admission to methadone treatment.
If oral fluid analysis yields results at least equivalent to accepted standard urinalysis, then the use of oral
fluid both in addiction treatment and other settings where urinalysis is commonly used today, and settings
where any matrix other than oral fluid is impractical (e.g., most epidemiological research), would be highly
supported.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1080/14659891.2022.2070872
发表时间:
2023
期刊:
Journal of substance use
影响因子:
0.8
作者:
[Weller,BridgetE, Magura,Stephen, Smith,DawnR, Saxton,MatthewM, Amaratunga,Piyadarsha]
通讯作者:
Amaratunga,Piyadarsha
Advancing the Use of Oral Fluid to Monitor Therapeutic and Illicit Drugs in Outpatient Clinical and Field Settings
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批准号:10020363
-
项目类别:
-
资助金额:$72.1万
-
财政年份:2019
-
负责人:Stephen Magura
-
依托单位:
Community Utilization of Evidence-Based Program Registers in Behavioral Healthcare
-
批准号:9307281
-
项目类别:
-
资助金额:$74.25万
-
财政年份:2017
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负责人:Stephen Magura
-
依托单位:
Critical Review of Evidence-Based Program Repositories for Behavioral Health Trea
-
批准号:8289401
-
项目类别:
-
资助金额:$18.63万
-
财政年份:2011
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负责人:Stephen Magura
-
依托单位:
Critical Review of Evidence-Based Program Repositories for Behavioral Health Trea
-
批准号:8196674
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项目类别:
-
资助金额:$22.35万
-
财政年份:2011
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负责人:Stephen Magura
-
依托单位:
Controlling for Endogeneity Biases in Estimating AA Effects on Drinking Outcomes
-
批准号:7921057
-
项目类别:
-
资助金额:$14.65万
-
财政年份:2009
-
负责人:Stephen Magura
-
依托单位:
Efficacy of "Dual Focus" Mutual Aid for Persons with Co-occurring Disorders
-
批准号:7372338
-
项目类别:
-
资助金额:$49.27万
-
财政年份:2008
-
负责人:Stephen Magura
-
依托单位:
Efficacy of "Dual Focus" Mutual Aid for Persons with Co-occurring Disorders
-
批准号:7847527
-
项目类别:
-
资助金额:$47.69万
-
财政年份:2008
-
负责人:Stephen Magura
-
依托单位:
Efficacy of "Dual Focus" Mutual Aid for Persons with Co-occurring Disorders
-
批准号:7643213
-
项目类别:
-
资助金额:$48.08万
-
财政年份:2008
-
负责人:Stephen Magura
-
依托单位:
Efficacy of "Dual Focus" Mutual Aid for Persons with Co-occurring Disorders
-
批准号:8061649
-
项目类别:
-
资助金额:$41.77万
-
财政年份:2008
-
负责人:Stephen Magura
-
依托单位:
Buprenorphine Maintenance for Opioid Addicted Persons in Jail and Post-Release
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批准号:7019701
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项目类别:
-
资助金额:$17.35万
-
财政年份:2006
-
负责人:Stephen Magura
-
依托单位:
Buprenorphine Maintenance for Opioid Addicted Persons in Jail and Post-Release
-
批准号:7229864
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项目类别:
-
资助金额:$20.22万
-
财政年份:2006
-
负责人:Stephen Magura
-
依托单位:
Trial of Self-Help Groups for Dually-Diagnosed Persons
-
批准号:6579321
-
项目类别:
-
资助金额:$55.73万
-
财政年份:2002
-
负责人:Stephen Magura
-
依托单位:
Control Trial of Self-Help for Dually-Diagnosed Persons
-
批准号:6930387
-
项目类别:
-
资助金额:$42.6万
-
财政年份:2002
-
负责人:Stephen Magura
-
依托单位:
Control Trial of Self-Help for Dually-Diagnosed Persons
-
批准号:6805974
-
项目类别:
-
资助金额:$61.16万
-
财政年份:2002
-
负责人:Stephen Magura
-
依托单位:
Control Trial of Self-Help for Dually-Diagnosed Persons
-
批准号:6669082
-
项目类别:
-
资助金额:$59.46万
-
财政年份:2002
-
负责人:Stephen Magura
-
依托单位:
INNOVATIVE JOB PLACEMENT MODEL FOR METHADONE PATIENTS
-
批准号:6379094
-
项目类别:
-
资助金额:$54.88万
-
财政年份:2000
-
负责人:Stephen Magura
-
依托单位:
INNOVATIVE JOB PLACEMENT MODEL FOR METHADONE PATIENTS
-
批准号:6802832
-
项目类别:
-
资助金额:$54.38万
-
财政年份:2000
-
负责人:Stephen Magura
-
依托单位:
INNOVATIVE JOB PLACEMENT MODEL FOR METHADONE PATIENTS
-
批准号:6523246
-
项目类别:
-
资助金额:$56.39万
-
财政年份:2000
-
负责人:Stephen Magura
-
依托单位:
INNOVATIVE JOB PLACEMENT MODEL FOR METHADONE PATIENTS
-
批准号:6664811
-
项目类别:
-
资助金额:$4.32万
-
财政年份:2000
-
负责人:Stephen Magura
-
依托单位:
INNOVATIVE JOB PLACEMENT MODEL FOR METHADONE PATIENTS
-
批准号:6662598
-
项目类别:
-
资助金额:$53.37万
-
财政年份:2000
-
负责人:Stephen Magura
-
依托单位:
海外基金